TRAINING MANUAL: OVERDOSE PREVENTION AND RESPONSE Thank you for taking the time to review this manual which will assist you in educating individuals about overdose prevention and response. This training includes education about the use of naloxone, an opioid antidote, to address the morbidity and mortality associated with opioid overdoses. An overview of naloxone, how it works and other details related to the Take Home Naloxone program in BC can be found at http://towardtheheart.com/naloxone/ Information in this manual comes from multiple sources including community, medical, and academic resources. Most importantly, it has come from people who use drugs who have taken the time to educate and share lived experiences in the ongoing effort to preserve life and prevent unnecessary deaths. Table of Contents: 1. 2. 3. 4. 5. 6. Who should use this training manual? Purpose of this Training Manual Who is eligible to receive a Take Home Naloxone kit? Preparing for a Training Session Session Introductions Participant Knowledge Objectives A. Factors that can increase or decrease risk of overdose B. How to recognize an overdose; including depressant and stimulant overdoses C. How to respond to an overdose; using SAVE ME, including: - how to put someone in the recovery position - how to communicate with 911and why it is important to call - how to prepare and administer naloxone - how and when to evaluate and support D. Completing the Take Home Naloxone Administration Information form 7. Video: Live! Using Injectable Naloxone to Reverse Opiate Overdose 8. Introduction to BC Take Home Naloxone Kit and Practice Injection 9. Record Keeping and Legal Considerations 10. Appendices Appendix A: Community Development and Engagement for a successful program Appendix B: Program Documents and Related Information I. Program Guide: Initiating & Implementing a Program II. Backgrounder III. FAQ’s IV. Overdose Prevention Training and Kits: Community Information V. Training Attendance Form VI. Pre/Post Test Quiz VII. SAVE ME Poster VIII. Administration Information Form IX. Certificate of Completion and Participant Knowledge Checklist X. Overdose Survival Guide – Tips to Save a Life XI. Sample Script XII. Dispensing Record 2012/08/29 [1 of 14] 1. Who should use this training manual? This training manual is to be used by the educator, who may be either the prescribing physician or another health-care professional (e.g. a registered nurse delegated by the prescribing physician) to perform the training session. The naloxone program webinar (which should be watched prior to initiating training) can be found at www.towardtheheart.com 2. Purpose of this Training Manual This manual provides the educator with the core knowledge that must be transmitted to the participant. This manual contains up-to-date information and resources that may be beneficial. Training can be modified to meet the requirements of the prescribing physician, available resources, and the group dynamics (i.e. size, history of use, etc.) or individual circumstances. Guiding questions are highlighted in sections to facilitate group discussion. The core information needed to be understood by participants is basic overdose prevention for stimulants and opioids, identification of an overdose, and response, including naloxone administration. 3. Who is eligible to receive a Take Home Naloxone kit? An individual who has received this training, has a history of using illicit opioids (illegal or diverted prescription), and has a written prescription from a physician is eligible to receive a Take Home Naloxone kit. Individuals who don’t use opioids, but know someone who does (e.g. support workers, peers of people who use opioids, family members) are not eligible to receive a kit. They are encouraged to attend the training to learn how to administer naloxone in an emergency and how to respond if naloxone isn’t readily available. Morbidity and mortality related to any kind of overdose is greatly reduced when the community has an increased awareness of how to mitigate risks, recognize, and respond appropriately in a timely manner. 4. Preparing for a Training Session The educator should use their professional discretion regarding inclusion of additional content, size of group, and the appropriate instructional methods to best engage participants. Group training sessions are encouraged in community and non acute settings and can be longer if appropriate. Allow time after group trainings for individual support/discussion. Length of training: individual training 15-20 minutes; group training 1-hour not including prescribing/dispensing of kits Resources Required (will depend on the environment, audience, group size, experience, and time): • Sample THN kit • Practice ampoules, gauze and VanishPoint® syringes - enough for all participants • Oranges or very thick sponge to practice injecting into and Sharps container • Forms (found in the appendix and online at towardtheheart.com) Attendance Form Certificates with Participant Pre/Post Quiz – one for each person Knowledge Checklist on the back note: print double-sided and cut in ½ one for each participant THN Administration Information Overdose Survival Guide – Tips to sample to show form in kit Save a Life - one for each participant • Pens and writing paper for participants • Audio/Video Set-up: laptop computer with internet access or recommended video downloaded Optional • Whiteboard or chart paper/markers/tape • Plastic Page Protectors for participant to put their certificate etc. in • Dolls to practice rescue breathing 2012/08/29 [2 of 14] Suggested tips from training experience: - Bring out sample THN kit and practice tools after video - Some paperwork can be filled out by educator/assistant during video to assist completion - Helpful to have SAVE ME written vertically on chart paper/board with words associated with each letter of the acronym to refer to - As the educator you may want to follow up with particular participants to clarify the knowledge they are taking away with them. The Participant Knowledge Checklist is a good guidance document to help in this process 5. Session Introductions “Today we are going to learn how to save a life in the event of an overdose.” • Let participants know the structure of the session: length, breaks (if any), content etc. • Introduce who you are, where you come from, and why you are offering overdose training. Acknowledge your position and the lived experience of the people who are receiving the training. • Tell participants if you don’t have answers to their questions – you will find out and let them know. Remember to make a note of questions for follow-up. If training in a group – suggested round-table of: Give name (as wish to be identified) and one thing that you would like to learn in the training today? • If training in a group, consider creating a group agreement by asking participants what is important to them for effective group functioning (e.g. confidentiality, speaking one at a time, respectful, etc.). • Encourage participants to take care of themselves; acknowledge that this can be a heavy topic – they may need to get up to take a quick break or use the washroom, can ask their neighbour to nudge them if they fall asleep, they may need to debrief after training etc. • Discussing your role as a facilitator and monitor can make it easier to keep the group on track later in the session. For example, let people know in advance that as the facilitator you may move the discussion along to be mindful of everyone’s time and to make sure you get through all the material, but will be available after the training for extra discussion, questions, and support. Pre-test Quiz Can be done individually or used to facilitate group discussion. Going through the questions as a group may help to address varying levels of literacy. Some people may not take the training if they think they have to be able to read. The post-test can be done at the end to solidify knowledge. 6. Participant Knowledge Objectives After completing the training, the participant will demonstrate an understanding of: A. Factors that can increase or decrease risk of overdose B. How to recognize an overdose; including depressant and stimulant overdoses C. How to respond to an overdose; using SAVE ME, including: - how to put someone in the recovery position - how to communicate with 911and why it is important to call - how to prepare and administer naloxone - how and when to evaluate and support D. Completing the Take Home Naloxone Administration Information form As an educator, you will: communicate that naloxone and Narcan® are different names for the same drug, that it only works in overdoses involving opioids. Naloxone is not the same as Naltrexone® dispel myths and acknowledge fears increase comfort and competency of participants to respond to an overdose rapidly and appropriately acknowledge the value of participants learning this life saving skill 2012/08/29 [3 of 14] Everyone will have experience with overdose – from personal experience, work, or other sources. Some knowledge about how to respond may be incorrect, take more time, and can cause harm. As the facilitator acknowledge many myths about how to respond to overdose exist and gently correct misconceptions. If someone in the group reports that an individual was “revived” by being given: an injection of salt water or milk, “opposite acting substance”, an ice bath or ice on their genitals, or beaten until they wake up; acknowledge that it may have “worked” in that instance. Any action someone used in the past to keep that person alive is commendable. Opioids suppress the brains ability to monitor and react to the lack of oxygen in the body; they need air. The quicker a person’s oxygen levels are increased or restored, by giving naloxone and/or by giving breaths, the better the chances are in preventing lifelong damages and death from opioid overdose. Clear the airway, give rescue breathing, and administer naloxone if you have it. Naloxone will not cause harm and is scientifically proven to reverse opioid overdose quickly. 6. Participant Knowledge Objective A: Factors that can increase or decrease risk of overdose What is an overdose? An overdose is when the body is overwhelmed by exposure to something, in this case a toxic amount of drug or combination of drugs which cause the body to be unable to maintain or monitor functions necessary for life. These are functions like breathing, heart rate, and regulating body temperature. Not everyone who overdoses will die; however, there can be long term medical impacts from overdose. Harm reduction includes creating connections to provide opportunities to discuss with individuals how they take care of themselves, while sharing knowledge, skills, resources and supports that are useful to them at that time in their life to promote safety and reduce death, harm, disease, and injury. Relevant and feasible strategies depend on the situation, are unique to each individual and may change. Anyone can overdose no matter their history or age. There is no exact formula. Overdose risk can increase or decrease depending on variables related to the 3 factors in the following figure: • • • Mixing Quantity Potency Quality/Cut • • • • • Age Tolerance Health Status Genetic Factors Other Medications • • • • • Injection Inhalation Ingestion Snorting Inserting What are some of the drugs people use? What are some of the drugs people combine? What are some things people could do to test the strength of a new batch? What are some ways to reduce the risks associated with these factors? What are some things you can do to look after your body to reduce overdose? When are some times a person’s tolerance might change? What are some things a person could do if they just got out of jail and bought heroin? (Possible answers: test drugs, buy from someone they trust, not use alone, be sure to have discussed OD plan, carry naloxone, smoke instead of inject until they have some tolerance etc.) 2012/08/29 [4 of 14] Substances: Mixing: mixing drugs with other substances, including alcohol, sleeping pills, cocaine Prescribed medications can also increase overdose risk – for example mixing either Ritonovir (HIV medication) or anti-depressants with Ecstasy Prevention: use one drug at a time, do not mix the highest risk ones (e.g. opioids, alcohol and pills), if you are going to mix anyway, choose to use opioids before alcohol or pills, and reduce the amount you take. Alcohol is often an underestimated risk factor; it impairs judgment and has an additive effect. People often think that mixing stimulants with a depressant will cancel out the risk. But people who speedball (mix) are at higher risk because the body has to process more drugs. Stimulants cause the body to use up more oxygen and depressants reduce the breathing rate. Let people around you know how much and what you are taking Quantity: amount of drugs used. Some drugs are harder to measure (e.g. GHB) or may have varying time release mechanisms (immediate vs. extended). Individuals may have taken more drugs intentionally or by accident, being unaware of the additive effects and the delayed onset Prevention: use standardized measuring (harm reduction programs have access to ordering syringe barrels without needle tips) or devise a readily available measuring method (e.g. pop bottle cap noting size and if it has the plastic liner or not). Wait before taking another dose, knowing it can take longer to feel the effects of some drugs. Not all opioids are created equal; practice caution when substituting or transitioning one opioid for another. Potency: concentration, quality, cut. Substances can have unknown content/adulterants due to processing (e.g. PMMA sold as MDMA). Other substances can be added by people who have handled drugs before the consumer either to expand the amount of product they have or to enhance the effects of the drugs. Inversely, sometimes drugs are not cut to change hands quickly Prevention: test your drugs, some places offer drug testing (raves/festivals) or test drugs by doing small amount at first, “two in the arm is better than one in the ground, [in the grave]”. Take the tourniquet off before depressing plunger, stop half way to see effects, inject less if it feels too strong. Purchase from reliable source (know your dealer). Check with community who might be in the know about current drugs in the area; people who use drugs, harm reduction service providers Individual Characteristics: Research shows having overdosed before, using alone or in an unfamiliar environment, and increased age are increased risk factors for fatal overdose. Tolerance: tolerance changes rapidly with even a few days of not using or reduced use. High risk times include: exiting jail, hospital, detox/treatment, and starting/tapering methadone maintenance Prevention: use less, do testers, change route of administration (injecting to snorting or eating drugs) until tolerance is developed Health Status: general physical health: liver, kidney, and respiratory function, compromised immune system, high blood pressure, heart disease, diabetes, smoking, current infections, sleep deprivation, dehydration, malnourishment, and mental health status can all play a part in overdose situations Prevention: eat, drink fluids like water, sleep, seek health care regularly as appropriate, go slow, take breaks, use less when you have been sick, lost weight, or feeling down – doing more to “feel better” is a risk factor for overdose Genetic factors: how an individual breaks down drugs can be influenced by genetic make-up Prevention: be informed. Know risks associated with different drugs and be aware the drug may be something different. Apply as many prevention measures as possible; discuss a plan with people you are with of what to do if something goes wrong 2012/08/29 [5 of 14] Other medications: The liver processes all drugs in a person’s body. A person with a damaged liver may be more prone to longer or more frequent overdoses Prevention: research or discuss with a health care provider you trust about interactions of the drugs you take; prescribed, over-the-counter, and drugs you get on the street. Route: Determines how quickly the drug takes effect. A fast injection into the vein will affect the body more quickly and intensely than ingesting. In general, the faster a drug hits blood stream (i.e. smoking or injecting), the greater the risk of overdose. You can still overdose even if you don’t inject. Prevention: Be careful when changing routes – you may not be able to handle the same amount. Consider snorting or ingesting if you are using alone or may have decreased tolerance. General Prevention messages: Don’t use alone, or use in a place where people can help if needed (leave doors unlocked etc.). A harm reduction strategy from someone who always uses alone is to know their limit and only buy drugs with consistent manufacturing methods Talk to an experienced person or trusted healthcare provider about reducing risk. If you have a relationship with health care provider or person you trust – let them know you are going to use and to ask them to check on you shortly Learn overdose response training, and carry naloxone Create an overdose plan with peers or family members so in the event of an overdose there is a quick and effective response, with no hesitation in calling 911. Talking about this before an emergency happens can clarify what needs to be done and reduce the responder’s anxiety; allowing them to act quickly and effectively, with no hesitation in calling 911 A checklist of suggested things to discuss in creating an overdose response plan include: Knowledge of overdose prevention If and when individual (who overdosed) wants techniques When to start OD response – colour and # of breaths per minute (<12breaths) When to call 911 When to administer naloxone Where is best to administer (shoulder or thigh) to go to the hospital Who else to call What to do with belongings while individual is treated for overdose Agreement to stay until naloxone wears off A commitment to not use again after being administered naloxone Potential for risk is created and heightened by social-structural environments; homelessness, having to inject in public, poverty, irregular drug supply, incarceration, and unsupported mental health; all these put people at greater risk for overdose. These are very important issues, but will not be addressed in today’s workshop. 2012/08/29 [6 of 14] 6. Participant Knowledge Objective B: How to recognize an overdose How do you recognize an overdose? (upper vs. downer) What does it look like when someone is overdosing on heroin? Who has seen an overdose? How did you know that it was different than a heavy nod? “The line between being someone being high and overdosing is unresponsive.” Call their name. Tell them to breathe. A medical emergency is when they do not respond to: someone calling their name, telling them to take a breath, or pain from a firm sternal rub (demonstrate taking knuckles and rubbing on breast bone). Call 911. Signs of overdose to look for are: Depressants (downers - including opioids) e.g. Alcohol, GHB, benzodiazepines Opioids*: morphine, dilaudid, heroin, methadone - Person can’t stay awake, walk or talk - Slow or absent pulse - Slow or absent breathing, snoring or gurgling. Less than 10-12 breaths per minute (a breath every 5 seconds is normal) - Skin looks pale or blue, especially nail beds and lips, feels cold - Pupils are pinpoint or eyes rolled back - Vomiting - Body is limp - No response to noise or knuckles being rubbed hard on the breast bone - Unresponsiveness Stimulants (uppers) e.g. Cocaine, crack, Ritalin®, methamphetamine, ecstasy - Fast pulse or no pulse - Short of breath - Body is hot/sweaty, or hot/dry - Racing pulse, shortness of breath - Confusion, hallucinations, unconscious - Clenched jaw - Shaky - Chest pain - Seizures, loss of consciousness - Vomiting - Cannot walk or talk - Rigid or jerking limbs *The term “opioid” is inclusive of the entire class of drugs, whether natural, semi-synthetic, or synthetic, that activate the body’s existing opioid receptors. “Opiate” refers only to drugs derived from opium. 6. Participant Knowledge Objective C: How to respond to an overdose The Recovery Position If you have to leave an unconscious/unresponsive person at any point, put them in the recovery position. This helps to keep the airway clear from their tongue or vomit. During an opioid overdose, the depressed breathing can cause the lungs to fill up with excess fluid – if you are not actively working on an individual (giving breaths or administering naloxone) put them in the recovery position. The potential for the lungs to fill up with fluid can happen quickly; this is another reason why calling 911 and the individual seeking medical attention is important. Demonstrate and practice the recovery position– pick the same leg as the hand that goes across the body to the opposite cheek. In the picture below it is the left leg and the left arm that get bent 2012/08/29 [7 of 14] In all overdose events it is recommended: To call 911, stay with the person, remain calm, use the person’s name when talking to them and calmly let them know what you are doing as you are doing it (even if they appear unresponsive). People who have overdosed have said someone using their name and talking to them calmly has made a big difference. Responding to a Stimulant Overdose: Stimulant Over-amp: If the individual is conscious and experiencing “over-amping” or mental distress (i.e. crashing from sleep deprivation, anxiety, paranoia) linked to stimulant use and you are sure this is not medical in nature, they may just need support and rest. Call Poison Control 1-800-567-8911 to help assess. Encourage them not to take any more substances. If possible move away from activity and noise, open a window, and place cool wet cloths on forehead, back of neck, and under armpits. Being careful not to over-hydrate; give water or other non-sugary, non-caffeinated drink to help replace lost electrolytes. If aggressive/paranoid ask if it helps if they close their eyes and be aware of their personal space. Call 911 at any point you are not comfortable. Stimulant Toxicity: If the individual has symptoms of stimulant toxicity, including rigid or jerking limbs, in and out of consciousness, seizures, rapidly escalating temperature and pulse, or chest pains this is a medical emergency. Call 911 immediately. The person needs immediate acute medical attention! This cannot be dealt with at home. Stay with the individual for support, encourage hydration, and stay calm. Do not give them anything by mouth if they are unconscious. If they are having a seizure make sure there is nothing around them that can hurt them. Do not put anything in their mouth or restrain them. There is no antidote to stimulant overdose. Naloxone will not help. If the heart has stopped provide chest compressions. Tell medical professionals as much as possible so they can give the right treatment to prevent organ damage and death. Responding to a Depressant Overdose: Support the person similar to an opioid overdose response without the administration of naloxone. Respond with the SAVE steps until the help arrives. Emphasize calling 911. Naloxone has no effect on depressant overdoses that do not involve opioids. However, if the overdose involves multiple substances including opioids, it will temporarily take opioids out of the picture. Responding to an Opioid Overdose: Fatal opioid overdoses are rarely instantaneous – they usually happen over 1-3 hours, are frequently witnessed but may not be recognized as an overdose. Therefore it is important to wake someone up if they are making unfamiliar snoring or gurgling noises. Many instances occur of individuals losing a loved one after hearing them “snore”, making unfamiliar sounds, and leaving them to sleep, to find out too late it was an overdose. Take the chance of them being upset that you woke them up. Give Breaths: If medical assistance or naloxone is not available – give breaths and stay with the person. Often this is enough to save someone’s life. Canada and US CPR Guidelines recently changed to “hands-only” CPR. However, in instances where a child or an adult has stopped breathing (choking, strangulation, drowning, or other respiratory issues) mouth-to-mouth improves survival. Most OD response programs recommend giving breaths in opioid OD because the person lacks oxygen. Only if the person has been oxygen deprived for a very long time or are without a heartbeat should they receive chest compressions. 2012/08/29 [8 of 14] Tell responder to go slow, continuously evaluating the impact of their actions on the individual, remembering to take breaths for themselves. Professionals are the best equipped to deal with an overdose situation - find extra support (if available) until they arrive. SAVE ME S A V E M E* Stimulate. Can you wake them? Call their name, give sternal rub (demonstrate), tell them to breathe. If you cannot wake them call 911. If you have to leave them, put them in the recovery position. Calmly, tell the operator that person is not breathing and not responsive. When approaching a stranger – use foot to nudge their foot, yelling at them to wake up. Be wary when approaching people who appear to be “sleeping” or “unresponsive”– be sure to say out loud the actions you are doing. Airway. Make sure nothing is in their mouth that keeps them from breathing – gum, food, pills, rig cap, etc. Ventilate. Breathe for them. Tilt head back, place barrier over mouth, plug nose, and give 2 breaths. Breath should be big enough to make person’s chest rise. Continue to breathe for the person – one breath every 5 seconds. Evaluate. Are they any better? If not, prepare naloxone. If you are the only responder, you can stop breaths temporarily while you get naloxone ready. In training: can ask participant to tuck chin down on their chest and try to breathe – demonstrating how a relaxed tongue can block airway. Moving head can sometimes get someone breathing again. Muscular Injection. Inject 1cc of naloxone into a muscle at a 90° angle. Outer thigh or the meaty part of the shoulder. Can give through clothing. Evaluate and Support. Is the person breathing on their own? Has their colour improved? If the naloxone has no effect within 5 minutes and opioids are involved* administer another dose of naloxone. Tell the person not to use anymore drugs for at least 2 hours. If person is feeling dope sick, tell them it will start to wear off in about 30 minutes and opioids in the system can reach the receptors again. Check breathing. A person needs to take a breath every 5 seconds. If person responds keep them moving and awake – watch them for several hours. Look, listen, feel if they are breathing. Head above mouth, look towards chest. Remind the individual that instructions are on the barrier. You cannot catch HIV by giving mouth to mouth. If you are still concerned about touching someone’s mouth and do not have a breathing mask – can give rescue breaths through a shirt placed over their open mouth and plugged nose. 10 second pulse check if (10-12 heartbeats in this time) Has breathing improved? Colour? If you do not have naloxone – just breathe. Keep breathing for them until the ambulance arrives. This can be very effective. Suggest individual takes a deep breath before administering naloxone. If this is not an opioid overdose naloxone will have no effect. Explain they may have to continue breathing normal sized breaths, every five seconds into person until the naloxone starts to work, and person starts to breathe on their own or until the ambulance arrives. Suggest counting out loud if it helps: one one thousand, two one thousand, three one thousand, four one thousand, breathe. Put needles in sharps container or plastic pop bottle with lid to dispose of safely. When the paramedics arrive – be sure to tell them as much as possible – what the person has taken and what steps you have taken. *If you haven’t called 911 yet, call NOW. It’s important to call 911 because: There might be another medical emergency that naloxone will not work for, or the overdose may not have been from opioids alone the person may overdose again when the naloxone wears off there is a small chance of side effects from the naloxone, such as a hypersensitivity (allergic) reaction 2012/08/29 [9 of 14] Acknowledge that there may be fears about calling 911. For example fear of legal risks (outstanding warrants, loss of children or housing), judgment from family or community, shame, past experiences, or other things they may have heard (being deported, murder charge, etc). But the person could die or suffer long-term consequences of an overdose if they do not receive adequate medical treatment. Stress the importance of staying with the individual after giving naloxone because: when the person wakes up they may have no memory of overdosing or receiving naloxone – explain to them what happened the person should be discouraged from using more opioids for at least 2 hours. Symptoms of withdrawal sickness will start to wear off in half an hour. Using more opioids will be a “waste”. While naloxone is in their system it blocks opioids from getting to receptors and they will continue to feel sick; it will also make the overdose more likely to return to tell the emergency response team as much as you know – what they took and what you have done so far 6. Participant Knowledge Objective D: Completing the THN Administration Information form A form is included in the kit to record the use of the naloxone. It can be filled out by the individual who received or administered the naloxone. Please fax all forms to the BC Harm Reduction Program (604.707.2516). This information is important to evaluate the kits, training, and the impact of the provincial initiative. Please complete as accurately as possible. If individuals need help filling out the form, someone at a local harm reduction site can help them to fill it out. The form can also serve as a tool for discussing the potentially traumatizing event. Acknowledge that using a naloxone kit can be a stressful experience for many individuals and talking to someone about it right away or days after the event may be helpful. Ask them to take care of themselves by doing this if needed. Involvement in an overdose can bring up memories of previous overdoses or deaths where if naloxone was available a life might have been saved. It can bring up grief and loss and mortality. It is important to acknowledge that an individual has taken the time to learn a very valuable skill to save someone’s life. This is a skill that everyone should have, but not everyone does. 7. Video: Live! Using Injectable Naloxone to Reverse Opiate Overdose (13:13 minutes) A great resource from the Chicago Recovery Alliance: http://www.youtube.com/watch?v=U1frPJoWtkw Explain that the naloxone used in the video is different than the naloxone in the BC THN kits. The video uses multi-dose vials; the BC initiative uses single dose glass ampoules to eliminate contamination risks and simplifies the dosage for administration. While the video is playing it may help to state the SAVE ME steps out loud as they occur in the video: Stimulate, Airway, Ventilate, Evaluate, Muscular Injection, Evaluate. 8. Introduction to BC Take Home Naloxone Kit and Practice Injection During the training, practice the skills important to respond to an overdose: • Show kit. Show SAVE ME instructions in the lid. Remove contents to discuss various pieces. • Explain the kit contains gloves and a breathing mask to practice universal precautions – creating a barrier and protecting both individuals. • Alcohol swab package – can use swab to wipe off skin prior to injecting or to cover ampoule. • Show that naloxone is wrapped in gauze in the labeled pill bottle in accordance with pharmaceutical regulations. The pill bottle is to protect the naloxone. • Taking Care of the Naloxone: Keep out of the sunlight and at room temperature. Don’t put in the refrigerator. 2012/08/29 [10 of 14] • Check the expiry dates of the naloxone periodically, it lasts about 2 years. If the naloxone gets close to the expiry date, suggest they bring it back for a new kit. The old kit can be used for demonstration. Demonstration and Practice with VanishPoint® syringe and water ampoule: • Remove VanishPoint® syringe from packaging. Explain it is an intra-muscular safety syringe. Compared to syringes used for intravenous injections, it has a larger needle (the lower the gauge the bigger the tip), and automatically retracts when the plunger is depressed all the way. • Holding practice glass ampoule (filled with water) upright by tip, swirl in a circular motion to gather all liquid in the base of the ampoule. This is an important step. • Put narrow tip of glass ampoule in open swab package or use the gauze provided. Hold the base with one hand and the covered top with the forefinger and thumb of the other hand and pull covered ampoule top towards you – thus breaking ampoule away from body. • Put the top aside and set ampoule down. Demonstrate that the ampoule is designed such that if it is inverted or tipped over, fluid will not come out. • Take the needle cover off the VanishPoint® syringe; draw up all the liquid from the ampoule. The 25g tip helps to avoid drawing any glass shards into the syringe. If there is air in the syringe, try to remove it without losing “naloxone”. Because the injection is going into a large muscle, having a small amount of air or glass in the syringe will not matter. The urgent need to restore breathing is more concerning. Show participant where muscular injection should go. • Hold an orange or dense sponge steady in one hand, hold the syringe like a dart insert into “flesh” at a 90° angle. Slowly depress the plunger of the VanishPoint® syringe all the way until the needle retracts. • Suggest safe disposal of syringe and ampoule into a sharps container or plastic bottle with lid. 9. Record Keeping and Legal Considerations Naloxone is not a controlled substance, and is specifically excluded from the Controlled Drug and Substance Act Schedule 1. It is regulated under the Federal Food and Drugs Act (Schedule F) making it a Prescription Only Medication (POM). As part of prescription regulations, patient information must on the prescription (full name, etc) and collected. Similar to any prescription medication at a pharmacy, the individual’s information is kept confidential. The BC Harm Reduction Program keeps a confidential record of this information. In the rare case a batch of medication is compromised from the pharmaceutical company, the individuals and the associated batch #’s need to be traceable. Data collection ensures accountability and will inform the program evaluation and potential expansion. None of the unique identifiers (names, birthdates, etc.) will be used for this part of the process. Individuals should keep the naloxone in the case in which it was dispensed with the paperwork; thus the naloxone container will have the individual’s name on it. Liability related to various aspects of naloxone is a common concern. There are no known cases of legal action related to naloxone. Many places have legislation protecting people who prescribe, dispense, or administer naloxone from liability, including 11 US states (see http://towardtheheart.com/naloxone/service-providers/ for references). Ask participants to let you know if they experience any problems from carrying naloxone. As part of implementing a successful naloxone program it is the THN teams’ role to work with their community to reduce potential barriers for people carrying naloxone. Please see Appendix A for considerations. For more information please see the legal opinion from PIVOT on www.towardtheheart.com End of training session content. More resources can be found on www.towardtheheart.com in the Naloxone section including links to papers, videos, games, and shorthand training documents from other programs. 2012/08/29 [11 of 14] 10. Appendix A: Community Development and Engagement for a Successful Program A key strategy of any successful program is assessing your local environment and building strong partnerships. Engagement in the early stages of development will provide opportunities to address concerns, help to increase community understanding and support; reduce the potential roadblocks in the future. Comprehensive and inclusive partnerships offer benefits such as: consistency in program development, increased support and uptake of new initiatives, reduced duplication of activities, cost effectiveness, increased reach and impact, and increased levels of information and knowledge about the issue in the community. Multi-agency collaboration, utilizing different expertise in the community, will help build a program that is best suited to the community needs. Engaging multiple partners in meaningful ways about drug use can help to build capacity within a community to provide coordinated care and reduce drug-related harm including stigma. All of these components are particularly important in increasing accessibility of harm reduction measures for all individuals. The more people that know about the THN being offered in the community the greater the chances that it reaches someone who is at risk. Enabling more individuals to become aware of how and where they can access resources to support their health and reduce social barriers (shame and stigma) that perpetuate isolation. Preventing and responding to overdose is often met with less opposition than other harm reduction initiatives. This may be a good framework to forge new partnerships and garner support. Overdose happens in all communities and populations who deal with pain. Naloxone education may be a way to engage communities that are resistant to acknowledging drug use or may have strict rules about substance use, or are less willing to talk about harm reduction. Law Enforcement and Emergency Responders People report not calling 911 due to fear of legal ramifications, therefore engaging law enforcement prior to program initiation is important. Developing communication strategies and working relationships with local law enforcement may reach beyond these key objectives and outcomes related to overdose: • Increase awareness about the overdose prevention initiative and naloxone kits. Highlight the program operates within provincial, federal, and medical professional regulations to train people who use opioids to prevent an overdose. Thus preemptively addressing legal concerns from policing/legal perspectives, to reduce problems for those carrying naloxone, and prevent confiscation • Discuss their current overdose response protocol • Police may have contact with individuals that are not connected to harm reduction programming – they may assist in referring individuals that may benefit • Communication plan between groups that support people who use drugs – i.e. overdose alerts and dissemination, feedback and updates about naloxone kits in the community • Potential for development of a memorandum of understanding/agreement e.g. Vancouver Police Department stating they would not attend overdoses that did not involve death or violence, agreements similar to Good Samaritan Legislation that provided limited immunity for individuals that provide assistance in overdose to encourage people to call 911 Inform emergency response networks within your region about the naloxone initiative. It is useful for paramedics, fire and rescue, and emergency room nurses and physicians to know of the support that their patient may have been given prior to their care. The FAQ’s (Appendix B: lll) and Overdose Prevention Training and Kits (Appendix B: lV) are useful documents to introduce the initiative and inform people about the project. These and other helpful resources are found on www.towardtheheart.com including links to police training resources and a sample letter from an outreach organization informing police of the program. 2012/08/29 [12 of 14] Suggested Communication Contacts: Aboriginal Orginizations Pharmacies – particularly ones that dispense methadone City (Mayor’s office etc.) Physicians that prescribe opioids Correctional Institutions including: release planners, officers, medical staff, probation offices Services that Support People Who Use Drugs Coroner’s Office Shelters Defense Lawyers’ Offices Street Nurses Detox Supportive Housing Drop-in Centres Drug and Alcohol Treatment Offices, Centres, Recovery Housing Support Groups for people who use drugs and for those that love them (ie AA/NA, Al-anon, LifeRing, Parent Support Groups) Drug User Groups ________________________________ Emergency Response Personel: 911 Call Centre Fire and Rescue Law Enforcement Paramedics ________________________________ Emergency Room Departments ________________________________ ________________________________ ________________________________ Health Authority Organizations and communities have different roles in addressing overdose deaths depending on their engagement with people at risk of overdose, their capacity, organizational mandate, and community readiness. The Canadian AIDS Aboriginal Network has a helfpul downloadable resource to assist in evaluating community readiness in implementing risk reduction strategies here: http://caan.netfirms.com/wpcontent/uploads/2012/05/CR-manual-eng.pdf 2012/08/29 [13 of 14] 10. Appendix B: Program Documents and Related Information For conveinence of making copies, the following documents do not have page numbers in the training manual. Click the title to jump to a specific document. Document PDF’s can also be accessed on www.towardtheheart.com/naloxone/ Provides information about the requirements needed to Program Guide: l. start distributing naloxone. Helpful in clarifying roles and Initiating & Implementing a Program associated responsibilites. Provides global and BC specific overdose and naloxone ll. Backgrounder information. Helpful to learn more about BC’s THN program and in approaching community partners. General FAQ’s for community not as familiar with how lll. FAQ’s preventable overdose can be and with people who use drugs. For more specific FAQ’s www.harmreduction.org Community information 1-pager with picture of kit. Overdose Prevention lV. Designed to inform stakeholders. Could add agency Training and Kits contact information if appropriate. Form for the Educator (s) to fill out and fax back to the BC Harm Reduction Program. Measures in filling out V. Training Attendance Form form and storing should be taken to ensure participant confidentiality. Helpful for training organizations to record numbers for community impact and funders. Print double-sided and cut in half. General overdose Vl. Pre/Post Training Quiz prevention and response questions to guide training and assess knowledge of group. Illustration shows the acronym SAVE ME as found in Vll. SAVE ME Poster the THN kit. Each letter lays out the action steps in an overdose response. Form in THN Kits to be shown to people being trained. To be filled out after an overdose event by individual Vll. Administration Information Form who responded to overdose or who overdosed and faxed back to BC Harm Reduction Program to assist in program evaluation. Print double-sided. Filled out by the educator. If the participant is eligible for a naloxone prescription, the Certificate of Completion form can be used to show the prescriber they have Vlll. and Participant Knowledge completed training. The checklist on the back serves as Checklist an overview of information the educator needs to cover and a reminder for participant of what they learned. Overdose Prevention and Response information suggested to be given to each particpant with with Overdose Survival Guide lX. certificate. Includes stimulant over-amp and toxicity info. – Tips to Save a Life If looking at the front cover – pamhlet is folded in “Z” fashion. Physicians will often have their own Rx pad. Some programs may make their Rx form for naloxone. Replace X. Sample Prescription (Rx) all components of this sample with your program’s prescribing physican information. Form to be completed by the THN Dispenser and faxed Xl. Dispensing Record back to the BC Harm Reduction Program to account for the kits that are sent to THN team. 2012/08/29 [14 of 14] TAKE HOME NALOXONE: PROGRAM GUIDE Initiating & Implementing a Program A considerable proportion of people at risk of illicit opioid overdose make little or no contact with primary health care services and service providers due to perceived barriers of initiating a relationship. Community organizations that have established relationships with people who use illicit opioids are an integral component of increasing access to naloxone in British Columbia (BC). In BC, naloxone, an opioid antagonist, must be prescribed for a specific person by a physician. Therefore significant challenges arise when developing a dissemination protocol that involves community-based organizations that may not have affiliated medical staff. The current dissemination protocol is designed to navigate the present policy environment as per federal, provincial and medical professional regulatory bodies. The long-term goals include the possibility of addressing policy changes. Delivering Take Home Naloxone (THN) kits to the target population entails collaboration between the educator, prescriber, and dispenser; however, an individual health care professional may take on more than one of these roles. The educator will educate participants using the curriculum developed by the BC Harm Reduction (BC HR) Program (found on www.towardtheheart.com) and evaluate the participants’ knowledge on behalf of the prescriber and dispenser. Each professional retains their respective responsibilities; the prescriber must be confident that the participant has the appropriate knowledge before prescribing naloxone. Therefore having reviewed the training curriculum and assessment the prescriber can delegate the training to the educator. THN collaborative team of educator, prescriber and dispenser will arise in a diversity of environments across the province and will function in ways best suited to the population they serve and individual circumstances. Teams may take varying forms; however, all tasks and deliverables outlined in the following table must be completed. Training documents and additional information can be found on the naloxone page on www.towardtheheart.com You may contact the BC Centre for Disease Control Harm Reduction Program to discuss your plan and program model at 604.707.2400 or email outreach@towardtheheart.com 2012/08/29 [1 of 2] Steps, roles, responsibilities, and deliverables when initiating and implementing a Take Home Naloxone program Identify Educate Who: Community Organizations & Health Care Professionals • Community-based partner organizations; outreach, clinic and hospital staff, work in collaboration with health care professionals to increase capacity to respond to overdose in the community and to identify individuals who would qualify for a THN kit BC HR Program Guiding Statement: People who are at risk of opioid overdose are eligible for a THN kit once appropriately trained Who: Educator • Conduct a training session with participants (usually 15-20 minutes for individual training) • Record those who have been trained using the Attendance Form and FAX it BC HR Program at 604.707.2516 • Assess knowledge and provide participants with a certificate of completion of training The educator assumes the education responsibilities on behalf of the prescribing physician. A standardized curriculum is used, but the physician may modify the curriculum or test the participant’s knowledge accordingly BC HR Program Guiding Documents: Service Provider Webinar, Training Video for Participants, Training Manual for Overdose Prevention & Response, Attendance Form, Pre & Post Quiz, Certificate of Completion and Participant Knowledge Checklist Deliverable Paperwork to BC HR Program: Attendance Form Who: Physician • Must establish or have a pre-existing, professional relationship with the participant and Prescribe confirm that the participant uses opioids • Upon receipt of the participant’s training certificate (or the physician performs the training themselves), write a prescription for naloxone • The physician holds all responsibility associated with the prescription BC HR Program Guiding Statement: Example Script: Naloxone 0.4mg IM q 5 minutes prn x 2 doses (1ml ampoule = 0.4mg) Dispense Track Who: Dispenser • Receive the original, hard copy of the prescription • Before dispensing the THN kit, remove the kit ID sticker from inside the naloxone container (matches the ID on the container, the kit, and the Administration Information form) and attach it to the prescription • Complete the naloxone label on the container: Fill in the date when naloxone is dispensed (not prescribed) Fill in the participant’s name, the physician’s name, address, and telephone number Some prescriptions may have a prescription number (‘Rx#’). If so, record the prescription number in the Rx# box, if not, leave it blank • Inspect the contents of the kit, including expiry date of the naloxone • Record information on the Dispensing Record • FAX Dispensing Record and associated prescriptions to BC HR Program at 604.707.2516 BC HR Program Guiding Documents: Program Guide (this document), Dispensing Record Deliverable Paperwork to BC HR Program: Dispensing Record and associated prescriptions Who: Take Home Naloxone teams; BC HR Program team • Upon use of the kit, the participant is requested to return the Take Home Naloxone Administration Information form to the site where they received the kit or nearest possible alternative. If the participant does not have a form, provide a blank form to complete • It is the responsibility of the site to FAX the form to BC HR Program at 604.707.2516 Deliverable Paperwork to BC HR Program: Take Home Naloxone Administration Information 2012/08/29 [2 of 2] TAKE HOME NALOXONE: BACKGROUNDER Opioid Overdoses in BC Opioid overdose is a public health issue in BC, contributing to significant mortality and morbidity. Province-wide in 2011, provisional data suggest over 275 deaths were attributed to illicit drug overdoses (96 in Fraser and 97 in Metro Vancouver regions). In 2011, the BC coroner’s service reported a cluster of drug overdose deaths related to an increase in heroin potency. Prescription opioids contributed to over 70 deaths in 2009. Total overdose events are likely higher than what has been reported as overdose does not necessarily result in death. However the lack of oxygen to the brain during an overdose event can lead to lifelong harms. Naloxone can prevent opioid morbidity and mortality Unintentional deaths from opioid overdose are preventable with overdose and naloxone education. Naloxone, or Narcan®, has been used in emergency settings for over 40 years in Canada and is on the WHO List of Essential Medicines. The BC ambulance service administered naloxone 2,367 times in 2011. It is a pure opioid antagonist which will quickly reverse life-threatening respiratory depression of opioids to restore breathing, usually in 2-5 minutes. Naloxone is not a controlled substance, it cannot be abused, and in the absence of narcotics has no pharmacologic activity. Research has shown having naloxone available does not increase risk taking behavior. Naloxone is a safe drug with minimal side effects, even less than an epi-pen. The American Medical Association adopted policies in 2012 supporting greater community access to naloxone: healthnewsdigest.com/news/Forecast_630/AMA_Adopts_New_Policies_at_Annual_Meeting.shtml Naloxone can be given by injection (into the vein or muscle or under the skin) or intra-nasal (sprayed into the nose). Naloxone for injection is currently the only formulation approved by Health Canada. The intra-muscular injection can be given through clothing into the muscle of the upper arm or upper leg. Naloxone Take-Home Programs in Canada and around the world Take Home Naloxone (THN) programs provide naloxone to people who use opioids (legally prescribed or illegally obtained) and are at risk of an overdose. It is not intended to replace emergency care or minimize the importance of calling 911. But because 85% of overdoses happen within the company of others, having naloxone offers the opportunity to save a life and reduce harms related to the overdose while waiting for the paramedics to arrive. Mathematical modeling in the US has demonstrated that naloxone, in conjunction with overdose education, has a synergistic effect; having a greater effect on reducing overdose events than if provided individually. Numerous programs already exist globally, including more than 180 programs in the US: www.cdc.gov/mmwr/preview/mmwrhtml/mm6106a1.htm. Edmonton started the first program in Canada in 2005, Toronto began in 2011, and in 2012 Ontario launched a provincial initiative to provide naloxone education and kits at harm reduction distribution sites: www.health.gov.on.ca/en/news/bulletin/2012/hb_20120404_1.aspx. BC’s Overdose Prevention Program is modeled on the successes of such programs and combines education (prevention, identification, and response to overdose) with a Take Home Naloxone (THN) kit for individuals who are using opioids, thus individuals can reduce overdose risks and be prepared in the event of an opioid overdose. BC’s Harm Reduction Program Since the BC Centre for Disease Control started preparation in January 2012, we have met with numerous stakeholders all of whom are supportive of the initiative. Letters of support have been received from Dr. Perry Kendall -the Provincial Medical Health Officer, the City of Vancouver, the Vancouver, Fraser, Interior, and Vancouver Island Health Authorities. The THN program Community Advisory Board includes people who use drugs, representatives from the BC Centre for Excellence in HIV/AIDS and the Vancouver Police Department. For more information visit www.towardtheheart.com 2012/08/29 [1 of 2] An article was published in the BC Medical Journal to increase awareness among physicians about the utilization of naloxone and the BC initiative: www.bcmj.org/bc-centre-disease-control/increasing-accessnaloxone-bc-reduce-opioid-overdose-deaths. The BC pilot program Distribution of naloxone kits will be piloted through the BC Harm Reduction Program. In BC naloxone is a prescription only medication (POM); therefore it must be prescribed to a specific individual with indications for personal use by a physician. BC has a unique challenge unlike other Canadian provinces that continue to utilize pre-written orders where a nurse can sign-off on a prescription or Medical Directives are in place. In BC, training can be performed by a health care provider (i.e. nurse) however; a physician must prescribe the kit to a named patient. Resources to assist organizations wanting to address overdose in their community are available from our website at: www.towardtheheart.com Considerations Naloxone is relatively safe with minimal potential adverse effects. The only contraindication to naloxone is hypersensitivity. Naloxone may precipitate withdrawal in individuals with opioid dependency. Naloxone should be used with caution in patients with a history of seizures and cardiovascular disease. However, the harms associated with oxygen deprivation during an opioid overdose are likely far more serious. Naloxone only works to take the opioids out of an overdose scenario; individuals may have confounding medical factors and substances that need acute clinical care. Therefore medical professionals are the best individuals to deal with an overdose. Calling 911 is an important component of the overdose response. Responders are taught to call 911 and stay with the individual for multiple reasons: to inform the person what has happened, to ensure that the person does not take more substances, to inform the medical response team of individual’s current state, and to administer a second dose of naloxone if the overdose returns. The effect of naloxone begins to wear off after 30 minutes, therefore the overdose may return. This will depend if the drug taken has a long half-life (e.g. methadone), how much was consumed, the individual’s metabolism (ability to break down the drugs) and other medical conditions. Conclusion Overdose and naloxone education programs are effective in communicating risks about substance use and will save lives. We believe there is a strong ethical responsibility to provide such services to individuals in BC who are at risk. We encourage people in BC affected by opioid overdose, physicians, policy makers, people who take opioids and their family members, and service providers, to identify ways they can reduce the occurrence and harmful consequences of opioid overdoses through education, and requesting and prescribing naloxone. For more information visit www.towardtheheart.com 2012/08/29 [2 of 2] TAKE HOME NALOXONE: FREQUENTLY ASKED QUESTIONS What is naloxone? Naloxone is an antidote to an opioid overdose. An overdose of opioid drugs such as morphine, heroin, methadone, or OxyContin® can cause a person’s breathing to slow or stop. Naloxone is an injectable medication that can reverse this so the person can breathe normally and regain consciousness. Naloxone does not work for overdoses such as cocaine, ecstasy, GHB or alcohol. However, if an overdose involves multiple substances including opioids, naloxone will help by temporarily taking the opioid out of the equation. Naloxone is also known by the trade name Narcan®. How is naloxone given? Naloxone can be given by injection (into the vein or muscle or under the skin) or intra-nasal (sprayed into the nose). In BC, the naloxone project is distributing injectable naloxone which is approved by Health Canada and is more effective than intranasal form. The injection can be given through clothing into the muscle of the upper arm or upper leg. Safety needles are provided with the naloxone to avoid needle-stick injuries. How does naloxone work? Naloxone and opioids bind to the same sites in the brain that effect breathing. While naloxone is active in the body, it binds more closely than the opioids; pushing the opioids off the sites in the brain and breathing is restored. Naloxone acts quickly, usually within five minutes. Its effect starts to wear off after 30 minutes and is gone by 90 minutes. By 90 minutes the body will have metabolized (broken down) some of the opioid and the person is unlikely to stop breathing again. Naloxone does not destroy opioids in the body. With large doses or long acting opioids, such as methadone, or in individuals with damaged livers, the person may need another dose of naloxone. What does overdose and naloxone training involve? Training provides knowledge about how to: reduce overdose risk, recognize different types of overdose, address myths, provide the correct emergency response and understand the importance of calling 911 and perform rescue breathing, place someone in the recovery position, and give naloxone. The knowledge and skills are not intended to replace emergency care. However, knowledge about overdose and administering naloxone can help keep someone alive while waiting for paramedics to arrive. Can naloxone cause harm or be abused? Naloxone is a very safe drug. It only works to block the effects of opioids in the brain and cannot get a person high. For individuals who are dependent on opioids it may cause them to go into withdrawal. This effect is minimized by the small doses of naloxone in the community kits. Naloxone does not encourage opioid use. It has no effect on someone who has no opioids in their system. Naloxone has been approved for use in Canada for over 40 years and is on the World Health Organization List of Essential Medicines. Does someone need to be a medical professional to recognize opioid overdose and administer naloxone properly to save a life? Research and experience show, if people are given basic training they are able to recognize an overdose and administer naloxone to save someone’s life just as well as a medical professional. For more information visit www.towardtheheart.com 2012/08/29 [1 of 2] If people who use drugs are given naloxone will they continue using and use more drugs? Research has shown having naloxone available does not increase risk taking behaviour. Providing overdose training with naloxone is a practical strategy to prevent death, focusing “on what is, as opposed to what should be”. Scotland has noted overdose initiatives offer the chance to save a life, and send a clear message to individuals that their lives matter. It is an important intervention, within comprehensive treatment and support, which can help reduce harm, encourage engagement with services and support people in improving their health. Are there risks associated with using naloxone? As with all drugs, the only contraindication to naloxone is hypersensitivity. Naloxone may precipitate withdrawal in individuals with opioid dependence; symptoms may include pain, hypertension (high blood pressure), sweating, agitation and irritability. It can be unsettling for someone to come out of an overdose situation unaware of events leading to that moment. People who have health conditions (heart, liver, respiratory etc) and/or have taken other substances need medical attention in an overdose situation. For these reasons, calling 911 is an important component of the overdose response. Why is it important to stay with an individual after giving them naloxone? Stay with an individual following naloxone use since the duration of action of some longer acting opioids may exceed that of naloxone. This means overdose may return, though it is usually less severe than the initial event as the body metabolizes or ‘breaks down’ the opioids. This is also why it is important that they do not take any more drugs for at least 2 hours. You may need to tell them what happened when they become conscious as they may be confused. It is important to tell the paramedics all that you know to inform their treatment plan. Where are Take Home Naloxone programs already established? The US has over 180 THN programs and many places have best practice policies that support coprescribing naloxone with any opioid. The American Medical Association adopted policies supporting further implementation of community naloxone programs to prevent unnecessary deaths. In the UK, people who have used opioids and are released from prison are given naloxone. Scotland has a national naloxone program. Edmonton started the first program in Canada in 2005 and Toronto started in 2011. Ontario started a provincial naloxone initiative in 2012. Naloxone has been used successfully to reverse opioid overdoses in thousands of people around the world. Who has access to naloxone now in BC? Currently the BC Ambulance Service, hospitals, and some clinics use naloxone. The Portland Hotel Society, including InSite, also use intranasal naloxone. A few doctors in BC prescribe naloxone to their patients but it is not currently covered by PharmaCare, so the patient pays for it fully. Why are opioid overdoses an important public health issue in BC? There are approximately 275 overdose deaths per year related to illicit drugs, and 70+ overdose deaths per year of people prescribed opioids in BC. Other long term effects occur in people who survive an overdose, like brain injury caused by the lack of oxygen to the brain during an opioid overdose. Naloxone can reduce these deaths and injuries. Where can I find more information? Visit the naloxone page on www.towardtheheart.com for up to date information and resources. For more information visit www.towardtheheart.com 2012/08/29 [2 of 2] TAKE HOME NALOXONE: OVERDOSE PREVENTION TRAINING AND KITS People who use opioids, either prescribed or who use them illegally are at risk of opioid overdose. In 2011, provisional data suggest over 275 deaths were attributed to illicit drugs in BC. .An additional 70+ deaths occurred in individuals’ prescribed opioid medication. Overdose events may not result in death so are even more frequent; however the lack of oxygen to the brain during an overdose can result in lifelong effects. Unintentional deaths and injury from opioid overdose are preventable with overdose and naloxone education. Naloxone, or Narcan®, quickly reverses the respiratory depression caused by opioids in an overdose. It is not a controlled substance, cannot be abused, and in the absence of narcotics has no pharmacologic activity. Research has shown having naloxone available does not increase risk taking behaviour. Naloxone is a safe drug with minimal side effects (even less than an epi-pen!). It may induce withdrawal in those who are opioid dependant. People at higher risk of overdose include those who: are initiating or tapering opioid therapy, have difficulty accessing primary care, have a period of non-use. Providing education regarding overdose prevention and response and increasing access to naloxone will reduce harms and save lives in BC. Participants who successfully complete community overdose prevention and response training and use opioids may be eligible to be prescribed naloxone. In addition to the kit, the training increases awareness about preventing overdose and provides the capacity to respond appropriately even if naloxone is not available in an overdose event. Overdose education provides the knowledge and skills to save a life while sending a clear message to individuals that their lives matter. It is an important intervention, within comprehensive treatment and support, which can help reduce harm, encourage connection to services, and support people in improving their health. Each Take Home Naloxone kit contains: • 2 glass ampoules of 0.4mg/ml naloxone wrapped in gauze inside a pill bottle for protection. Label includes provincially designated prescription information • 2 retractable VanishPoint® safety syringes: 3cc – 25g x 1” • 2 alcohol swabs • 2 latex gloves • One-way rescue breathing barrier mask • THN Administration Information Form with Kit Identifier Information • Steps to respond to opioid overdose For more information visit www.towardtheheart.com 2012/08/22 [1 of 1] OVERDOSE PREVENTION AND RESPONSE TRAINING: ATTENDANCE Educator/Trainer(s):__________________________________________________ YYYY MM DD Date: ________/_____/______ Affiliation/Agency: ___________________________________________________ Site: ___________________________________ Prescriber(s): ________________________________________________________________________________________________ Date training 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 Participant’s Full Name Person (check all that apply) uses opioids eligible to receive naloxone kit is staff is a peer is a volunteer cares about a person who uses opioids Person (check one) completed training & received naloxone kit completed training only Staff to fill out form to ensure confidentiality. Please FAX to the BC Harm Reduction Program at 604.707.2516 at end of session or when form completed 2012/08/29 [1 of 2] didn’t complete training Trainer’s notes and reflections to be filled out after training (things that went well, things to do differently, feedback): ___________________________________________________________________________________________________________ ___________________________________________________________________________________________________________ ___________________________________________________________________________________________________________ ___________________________________________________________________________________________________________ ___________________________________________________________________________________________________________ ___________________________________________________________________________________________________________ ___________________________________________________________________________________________________________ ___________________________________________________________________________________________________________ ___________________________________________________________________________________________________________ ___________________________________________________________________________________________________________ ___________________________________________________________________________________________________________ ___________________________________________________________________________________________________________ ___________________________________________________________________________________________________________ ___________________________________________________________________________________________________________ ___________________________________________________________________________________________________________ ___________________________________________________________________________________________________________ __________________________________________________________________________________________________________ 2012/08/29 [2 of 2] PRE-TRAINING QUIZ PRE-TRAINING QUIZ 1) What can increase your risk of having an overdose? (choose best answer) a) mixing drugs b) mixing drugs and alcohol c) using after a period of non-use d) all of the above 1) What can increase your risk of having an overdose? (choose best answer) a) mixing drugs b) mixing drugs and alcohol c) using after a period of non-use d) all of the above 2) Which of the following is not a sign of an opioid overdose? a) person unable to be woken up b) not breathing at all or breathing very slowly c) turning blue/purple around lips and fingertips d) increased energy, wanting to exercise 2) Which of the following is not a sign of an opioid overdose? a) person unable to be woken up b) not breathing at all or breathing very slowly c) turning blue/purple around lips and fingertips d) increased energy, wanting to exercise 3) Is it essential that you call 911 for all overdoses? a) Yes b) No 3) Is it essential that you call 911 for all overdoses? a) Yes b) No 4) Does naloxone work for a cocaine overdose? a) Yes b) No 4) Does naloxone work for a cocaine overdose? a) Yes b) No 5) How many doses of naloxone should you administer for an opioid overdose? a) 10 doses b) 1 dose initially, possibly 2 c) 1 dose 5) How many doses of naloxone should you administer for an opioid overdose? a) 10 doses b) 1 dose initially, possibly 2 c) 1 dose 6) Why must you stay and support the person that overdosed? (choose best answer) a) naloxone may wear off and overdose may return b) may need to give a 2nd dose of naloxone c) provide important information to EMS d) a person’s health and other drugs can make OD’s complicated e) all of the above 6) Why must you stay and support the person that overdosed? (choose best answer) a) naloxone may wear off and overdose may return b) may need to give a 2nd dose of naloxone c) provide important information to EMS d) a person’s health and other drugs can make OD’s complicated e) all of the above 7) How many mL’s (1 mL= 1 ampoule) of naloxone do you administer for each dose? a) 5 mL c) 10 mL b) 1 mL d) 0.5 mL 7) How many mL’s (1 mL= 1 ampoule) of naloxone do you administer for each dose? a) 5 mL c) 10 mL b) 1 mL d) 0.5 mL 8) How long does it take for naloxone to start working once given IM (intramuscularly)? a) 10 min b) 1-5 min c) 20 min 8) How long does it take for naloxone to start working once given IM (intramuscularly)? a) 10 min b) 1-5 min c) 20 min 9) How long does the effect of naloxone last before it starts to wear off? a) 15 min b) 30 min c) 3 hours 9) How long does the effect of naloxone last before it starts to wear off? a) 15 min b) 30 min c) 3 hours 2012/08/29 [1 of 2] POST-TRAINING QUIZ POST-TRAINING QUIZ 1) What can increase your risk of having an overdose? (choose best answer) a) mixing drugs b) mixing drugs and alcohol c) using after a period of non-use d) all of the above 1) What can increase your risk of having an overdose? (choose best answer) a) mixing drugs b) mixing drugs and alcohol c) using after a period of non-use d) all of the above 2) Which of the following is not a sign of an opioid overdose? a) person unable to be woken up b) not breathing at all or breathing very slowly c) turning blue/purple around lips and fingertips d) increased energy, wanting to exercise 2) Which of the following is not a sign of an opioid overdose? a) person unable to be woken up b) not breathing at all or breathing very slowly c) turning blue/purple around lips and fingertips d) increased energy, wanting to exercise 3) Is it essential that you call 911 for all overdoses? a) Yes b) No 3) Is it essential that you call 911 for all overdoses? a) Yes b) No 4) Does naloxone work for a cocaine overdose? a) Yes b) No 4) Does naloxone work for a cocaine overdose? a) Yes b) No 5) How many doses of naloxone should you administer for an opioid overdose? a) 10 doses b) 1 dose initially, possibly 2 c) 1 dose 5) How many doses of naloxone should you administer for an opioid overdose? a) 10 doses b) 1 dose initially, possibly 2 c) 1 dose 6) Why must you stay and support the person that overdosed? (choose best answer) a) naloxone may wear off and overdose may return b) may need to give a 2nd dose of naloxone c) provide important information to EMS d) a person’s health and other drugs can make OD’s complicated e) all of the above 6) Why must you stay and support the person that overdosed? (choose best answer) a) naloxone may wear off and overdose may return b) may need to give a 2nd dose of naloxone c) provide important information to EMS d) a person’s health and other drugs can make OD’s complicated e) all of the above 7) How many mL’s (1 mL= 1 ampoule) of naloxone do you administer for each dose? a) 5 mL c) 10 mL b) 1 mL d) 0.5 mL 7) How many mL’s (1 mL= 1 ampoule) of naloxone do you administer for each dose? a) 5 mL c) 10 mL b) 1 mL d) 0.5 mL 8) How long does it take for naloxone to start working once given IM (intramuscularly)? a) 10 min b) 1-5 min c) 20 min 8) How long does it take for naloxone to start working once given IM (intramuscularly)? a) 10 min b) 1-5 min c) 20 min 9) How long does the effect of naloxone last before it starts to wear off? a) 15 min b) 30 min c) 3 hours 9) How long does the effect of naloxone last before it starts to wear off? a) 15 min b) 30 min c) 3 hours 2012/08/29 [2 of 2] For more information visit www.towardtheheart.com TAKE HOME NALOXONE: ADMINISTRATION INFORMATION After kit use, please return this form to your regular or nearest harm reduction supplies distribution site as it will help us to improve the program. Completing this form with a staff member may help you debrief after an overdose event. Name:_________________________________________________ I am ☐ the person who overdosed ☐ the person who responded 1. When did the overdose occur? Date: ______/___/____ YYYY MM DD YYYY MM DD Date: ______/____/_____ 2. Who administered the naloxone? (check all that apply) ☐ partner ☐ family member ☐ friend ☐ acquaintance ☐ stranger ☐ self ☐ health worker ☐ other:___________________________________ 3. Where did the overdose occur? ☐ private residence ☐ shelter ☐ on the street ☐ hotel ☐ supportive housing ☐ other: ______________________________ 4. What drugs were involved in the overdose? (check all that apply) ☐ heroin ☐ codeine ☐ morphine ☐ fentanyl ☐ oxycodone ☐ methadone ☐ alcohol ☐ meth ☐ GHB ☐ cocaine/crack ☐ benzodiazepines, ‘benzos’ (eg: valium) ☐ additional:____________________________ 5. Why do you think the overdose occurred? ☐ reduced tolerance to opioids (eg: a break from using) ☐ change in purity ☐ polydrug use, specify:_________________________ ☐other:______________________________ 6. Did the person who overdosed and received naloxone… i) experience any symptoms of withdrawal? ☐ none ☐ mild ☐ severe ii) display aggression because of these symptoms? ☐ yes ☐ no 7. How long did it take for naloxone to work? Time (minutes):_________________________ ☐ it didn’t work 8. Was the person who overdosed made aware… (i) that the effects of naloxone wear off in 30-90 minutes? ☐yes ☐no (ii) that overdose can return and to avoid using for a couple of hours? ☐ yes ☐ no 9. How many ampoules of naloxone were administered? ☐ 1 ☐ 2 10. Was 911 called? ☐ yes ☐ no If no: what prevented a call to 911? ☐ worried that police would become involved ☐ other:_______________________________ If yes: did the police attend? ☐ yes ☐ no ☐ thought person would recover on own 11. Did the person survive the overdose? ☐ yes ☐ no ☐ I don’t know 2012/08/29 [1 of 2] COMPLETE PAGES 1 and 2 AND FAX TO 604.707.2516 12. If the person survived, in your opinion, did the naloxone prevent the person dying from an overdose? ☐ yes ☐ no 13. Were the naloxone kit contents easy to access and use? ☐ yes ☐ no 14. What actions were taken during the overdose on this occasion? (check all that apply) ☐ checked breathing ☐ stayed with person until they come round ☐ gave stimulants (eg: coffee) ☐ walked the person around the room ☐ slapped or shook the person ☐ injected saline ☐ shocked the person with cold water ☐ placed the person in the recovery position ☐ performed mouth-to-mouth resuscitation ☐ stayed with the person until the ambulance ☐ taken to the hospital (by: ☐ EMS ☐ other) arrived ☐ checked pulse ☐ checked airways for obstruction ☐ other:_______________________________ ☐ gave chest compressions 15. If you were in a similar situation again, do you think giving naloxone would be a good thing to do? ☐ yes ☐ no ☐ unsure If no/unsure, why? _________________________________________________________________ 16. Did you feel that you had enough training to give naloxone? ☐ yes ☐ no If no, what could be done to better prepare you? _______________________________________ _________________________________________________________________________________ 17. How did you know that an overdose was happening? Person who administered naloxone: Person who received naloxone (describe): ______________________________________ ☐ person turned blue ______________________________________ ☐ person wouldn’t wake up ______________________________________ ☐ person stopped breathing ______________________________________ ☐ no response to sternal rub & shout (stimuli) ☐ other:_______________________________ ______________________________________ 18. Where do you keep your naloxone kit? ________________________________________________________________________________ 19. Do you experience any barriers carrying your naloxone kit? (eg: being ID’d as a drug user, awkward to carry, etc) ☐ no ☐ yes, specify:_____________________________________________ 20. Do you have a tip that you’d like to share about using naloxone kits? (eg: telling your family where you keep your kit) _____________________________________________________________ _________________________________________________________________________________ _________________________________________________________________________________ 21. Where did you get your naloxone kit? _____________________________________________ 22. Where did you return this form? __________________________________________________ eg: health unit, harm reduction service provider TAKE HOME NALOXONE KIT The owner of this kit has been trained in overdose prevention and response and has been provided these harm reduction supplies by the BC Harm Reduction Strategies and Services Committee. TO FIND HARM REDUCTION DISTRIBUTION SITES & MORE INFORMATION ABOUT NALOXONE, VISIT: www.towardtheheart.com OR CONTACT Ph: 604.707.2400 Fax: 604.707.2516 E-mail: outreach@towardtheheart.com website: www.towardtheheart.com Return this form to your regular or nearest harm reduction supplies distribution site for replacement details KIT ID: 2012/08/29 [2 of 2] COMPLETE PAGES 1 and 2 AND FAX TO 604.707.2516 CERTIFICATE OF COMPLETION This certificate is awarded to __________________________________________ In recognition of Overdose and Naloxone Education training to Save A Life BC Harm Reduction Program YYYY / MM / DD Educator’s Signature Organizati on Educator’s Name (Print) ___________________________________________________ Organization Date TAKE HOME NALOXONE: PARTICIPANT KNOWLEDGE CHECKLIST This checklist provides a guideline to assess the knowledge of the participant following the training session. As the Educator you should be confident that each knowledge objective was covered in the training and that the participant understands each of the objectives. Participant’s Name: __________________________________________ Date: ______/_____/_____ YYYY MM DD Educator’s Name (Print):______________________________________ Initials Knowledge Objective • Demonstrates clear knowledge of causes, contributing factors, and Overdose prevention strategies to overdoses Prevention •Demonstrates understanding of stimulant overdose – there is no antidote •Knows the application of myths in responding to overdose can be harmful Signs of Opioid Overdose • Understands the signs of an opioid overdose: breathing is very slow/ erratic or not there at all, fingernails/lips blue or purple, unresponsive to stimulation/sternal rub, deep snoring/gurgling sound, body is limp, unconscious • Understands that naloxone does not work for non-opioid overdoses Recovery Position and Calling 911 • Can demonstrate the recovery position and knows to put the person in this position if they have to leave them alone to keep airway clear • Understands the importance of calling 911, knows what to say to the 911 operator and knows to debrief EMS when they arrive Stimulation & Application of Breaths • Demonstrates understanding of how to provide stimulation: Sternal Rub/Say the person’s name/Tell them to breathe • Demonstrates understanding of how to provide breaths and use 1-way face mask Naloxone Administration • Demonstrates understanding, including: 1 mL into muscle of upper shoulder, upper thigh, or upper-outer quadrant of buttocks. If no change in condition within 3-5 minutes – should give another dose of naloxone Evaluation & Aftercare • Demonstrates knowledge that the effect of naloxone only lasts 30-90 minutes and the overdose can return • Knows to stay with person to communicate to that person: what happened, not to let person take more drugs; sickness will go away, more opioids will have no effect while naloxone is active, and more drugs will make OD more likely to return when effect of naloxone wears off • Knows to watch for OD symptoms returning Care of Naloxone Vial, Program Evaluation, Refill • Demonstrates knowledge how to store naloxone at room temp and away from light • Watch expiry date on ampoules • Keep naloxone in a regular place and let others know where it is in case of an emergency • Knows how to get a repeat prescription, and if need more information to go to www.towardtheheart.com • Knows the importance of completing and returning the Administration Information form 2012/08/22 OVERDOSE SURVIVAL GUIDE PREVENTION THE RECOVERY POSITION OVERDOSE IS MOST COMMON WHEN: KEEP THE AIRWAY CLEAR • Your tolerance is lower: you took a break, were in detox/treatment or jail, or you are new to use • You have been sick, tired, run down, dehydrated or have liver issues TIPS TO SAVE A LIFE • You mix drugs: prescribed or not, legal or illegal • The drugs are stronger than you are used to: changes in supply, dealer, or town TO PREVENT OVERDOSE: Hand supports head • Know your health status and your tolerance • Do not mix drugs and alcohol. If you do mix, choose to use drugs before alcohol Knee stops body from rolling onto stomach • Be aware: using drugs while on prescribed medications can increase overdose risk • Don’t use alone. Leave door unlocked. Tell someone to check on you • Do testers to check strength. Use less. Pace yourself • Talk to an experienced person or a trusted healthcare provider about reducing risk • Know CPR and get trained on giving naloxone • Choose a safer route of taking drugs Stay with person. If you must leave them alone at any point, or if they are unconscious, put them in this position to keep airway clear and prevent choking. 'EPPJSVLIPT. CHOOSE A SAFER ROUTE SAFER / NO USE Overdose Prevention and Response SWALLOWED SNORTED / SMOKED / INSERTED INJECTED MORE LIKELY TO OVERDOSE OVERDOSE? TAKE CHARGE. TAKE CARE. OPIOIDS / DEPRESSANTS (e.g., opiods: morphine, dilaudid, heroin / depressants: alcohol, GHB, benzodiazepines) • Stay with person. Use their name. Tell them to breathe • Person cannot stay awake IN CASE OF OPIOID OVERDOSE: FEELS AND LOOKS LIKE: • Can’t talk or walk • Slow or no pulse • Slow or no breathing, gurgling • Skin looks pale or blue, feels cold • Pupils are pinned or eyes rolled back • Vomiting • Body is limp • No response to noise or knuckles being rubbed hard on the breast bone • Call 911 and tell them person is not breathing. When paramedics arrive tell them as much as you can about drugs and dose • Use naloxone if available. Naloxone only works on opioid overdose • After naloxone a person might feel withdrawal. Do not take more drugs. Sick feeling will go away when naloxone wears off (30 – 75 minutes). Be aware: overdose can return SAVE ME S stimulation A airway evaluate E ventilate V Can you wake them up? If not, call 911 Make sure there’s nothing in their mouth that stops them from breathing. Breathe for them. (Plug nose, tilt head back, and give 1 breath every 5 secs). Are they any better? Are you trained to give naloxone? M muscular injection Inject 1cc of naloxone into a muscle. E evaluate & support Is the person breathing on their own? If they’re not awake in 5min, another 1cc dose is needed. Tell the person not to use any more drugs right now – wait at least 2 hours. This is proven to work. Other remedies can actually be harmful. STIMULANTS (e.g., cocaine, methamphetamine, ecstasy) ASSESSMENT: ARE THEY EXPERIENCING A OR B? FEELS AND LOOKS LIKE: • Cannot talk or walk • Confusion, hallucinations, unconscious • Vomiting • Body is hot/sweaty, or hot/dry • Seizures • Short of breath • Chest pain • Fast pulse or no pulse • Clenched jaw B: PHYSICAL DISTRESS/ACUTE STIMULANT TOXICITY A: MENTAL DISTRESS/OVERAMP Associated with: sleep deprivation, crashing, anxiety, paranoia. If a person is conscious, and you are sure this is not medical in nature, they may just need support and rest. Call Poison Control to help assess. Medical attention is required immediately if person has: • Jerking or rigid limbs • Rapidly escalating body temperature and pulse • In and out of consciousness WHAT TO DO: • Shaky There are NO medications to safely reverse a stimulant overdose. 0!-0(,%4).&/2-!4)/."#(EVQ2IHYGXMSR4VSKVEQ Tel: 604.707.2400 e-mail: outreach@towardtheheart.com OVERDOSE INFORMATION: Poison Control Centre (24 hrs) Tel: 1-800-567-8911 • Severe: headache, sweating, agitation • Keep calm. Stay with person. Use their name • Chest pains • Give water or fluid with electrolytes. Do not overhydrate WHAT TO DO: • Place cool, wet cloths under: armpits, back of neck, and head • Keep person: conscious, hydrated, calm • If aggressive/ paranoid suggest they close their eyes, give person space • Stay with person • Get them comfortable. Move away from activity • Call 911 • Open a window for fresh air • Encourage person not to take any other substances • Doctor may treat agitation and paranoia with a benzodiazepine If you’re not comfortable with the situation, call 911. EMERGENCY RESPONSE: Tel 9-1-1 • If heart has stopped do ‘hands-only’ CPR • Tell medical professionals as much as possible so they can give the right treatment to prevent organ damage and death Dr. O.D. Prevention, MD, General Practitioner The Best Practice Clinic 456 Everywhere Avenue Ollover, BC B4U 0D9 Tel: 555.555.5911 Kit ID/Rx #: Fax: 555.555.5911 Date: YYYY / MM / DD Patient details: Last Name: _________________________ First Name:__________________________ Date of Birth:_______________________ PHN:_______________________________ Address:________________________________________________________________ Rx Naloxone 0.4mg (=1mL) IM q 5 minutes prn x 2 doses Indication: For reversal of opioid overdose No repeats. ________________________________ Dr. O.D. Prevention (MSP 55555) For more information visit www.towardtheheart.com 2012/08/29 TAKE HOME NALOXONE: DISPENSING RECORD Upon receipt of the naloxone prescription, complete the following form and store with the hard copies of the prescriptions. Once full (or at your discretion), fax this form and the associated prescriptions to the BC Harm Reduction Program at 604.707.2516 DATE (YYYY/MM/DD) PARTICIPANT’S FULL NAME DISPENSER’S NAME KIT ID NUMBER Please complete this section to help us evaluate the program st 1 Kit Replacement Kit Reason: Used Expired st 1 Kit Replacement Kit Reason: Used Expired st 1 Kit Replacement Kit Reason: Used Expired st 1 Kit Replacement Kit Reason: Used Expired st 1 Kit Replacement Kit Reason: Used Expired st 1 Kit Replacement Kit Reason: Used Expired st 1 Kit Replacement Kit Reason: Used Expired st 1 Kit Replacement Kit Reason: Used Expired st 1 Kit Replacement Kit Reason: Used Expired st 1 Kit Replacement Kit Reason: Used Expired Lost Stolen Confiscated Lost Stolen Confiscated Lost Stolen Confiscated Lost Stolen Confiscated Lost Stolen Confiscated Lost Stolen Confiscated Lost Stolen Confiscated Lost Stolen Confiscated Lost Stolen Confiscated Lost Stolen Confiscated WHEN FULL, FAX THIS FORM WITH ALL LISTED PRESCRIPTIONS TO THE BC HARM REDUCTION PROGRAM AT 604.707.2516 2012/08/29 [1 of 1]
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