1. No category

You are invited to attend a seminar by
Professor Steven A Siegelbaum
Regulating memory storage by trafficking HCN1 channels to neuronal dendrites
Ion channels are often selectively targeted to distinct neural compartments where they regulate specific aspects of neural
activity. The HCN1 hyperpolarization-activated cation channels are highly enriched in the distal dendrites of CA1 pyramidal
neurons in the mammalian hippocampus, a brain structure critical for memory storage.
In this seminar, Professor Siegelbaum (Chair of Neuroscience and Professor of Pharmacology at Columbia University
Medical Center, New York City, USA) will describe how HCN1 channels act to constrain both the excitatory effects of
cortical inputs that innervate CA1 distal dendrites and hippocampal-dependent learning and memory. He will discuss
how the HCN1 channel auxiliary subunit, TRIP8b, and the extracellular signaling molecule Reelin are necessary for the
dendritic localization of these channels, and how alterations in Reelin signaling may contribute to HCN1 mislocalization
in neuropsychiatric disease.
Event Details
Date:
Time:
Venue:
Monday 20 April 2015
4 pm
Confucius Institute,
Building 202, Level 4, Room 2
RMIT Bundoora campus west
Clements Drive (off Plenty Road)
Bundoora, Victoria
RSVP
Contact: Michelle Nicolo
Email: healthinnovations@rmit.edu.au
Tel. +61 3 9925 6606
www.rmit.edu.au/research/institutes/healthinnovations
www.rmit.edu.au
14087 0415
BUNDOORA CAMPUS EAST & WEST
LEGEND
A
Wind Tunnel
« tram: 86 »
Bundoora
campus
east
257
the Hub
B
Bus stop
252
C
Tram stop
254
251
McKimmies Road
D
253
Plenty Road
Plenty Road
Bundoora
campus
west
Library
258
E
255
211
Building number
Hall
Landmark
P
Parking
Security
F
256
G
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
McKimmies Road
H
H
208
J
K
ot
ba
ll
Tennis Courts
Fi
el
d
Hockey Field
213
220
209
Lake
214
217
203
204
M
205
201
J
K
223
211
Plenty Road
L
I
Fo
« tram: 86 »
Athletics Track
& Soccer Field
Student Amenities Building
206
L
M
202
N
N
224
210
207
215
nts
e
lem
222
ve
Dri
« tram: 86 »
O
C
216
P
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
O
P
Produced from information supplied by Property Services, 9 April 2014.
I
21
Produced from information supplied by Property Services. Bundoora campus map ver 8 April 2014.
www.rmit.edu.au/about/campuses
The Hub offers current RMIT students
service, advice and information.
www.rmit.edu.au/students/hub
» the Hub at Bundoora campus west
Building 202, Level 2, Room 36
Opening hours: 9 am – 5 pm
 RMIT Campus Store
Building 202, Level 2, Room 1
 Libraries
Building 210
Building 251, Level 2, Room 4
 Cafes
Building 251, Level 2
Building 201, Level 2
Building 202, Level 2
Building 220, Level 2
 Bundoora Netball and Sports Centre
Building 203, Level 1