Nutritional Solutions for a Pharmaceutical World Dissolving the Pharmaceutical Myth Gerald Roliz, CNC, MBA March 16, 2015 1 Disclaimer This presentation is intended for healthcare practitioners only. The information provided is an introduction to the use of whole food concentrates and herbal remedies and does not purport to be a complete discussion of nutrition, chiropractic, traditional chinese medicine or whole food concentrates. The information in this seminar should not be constructed as a claim or representation that any procedure or product mentioned constitutes a specific cure, palliative or remedy for any condition. The material and information contained in this seminar is not for the diagnosis or treatment of disease. They are designed to assist doctors and other healthcare practitioners in evaluating the patients metabolic and nutritional status. The information is also intended to help determine those foods and food supplements that are either excessive or insufficient in the patient’s diet. This allows for a better understanding of balanced body biochemistry. The information presented is for educational purposes only. It is the sole responsibility of the healthcare practitioner using this information to determine if what is outlined herein is appropriate for his or her purpose. 2 “Live in a world where all men, women and children have an opportunity to live a life, healthy and un-medicated.” Vision Statement 3 Background • U.C. Berkeley – Molecular & Cell Biology – Psychology • Pharmaceutical Sales Representative • Masters in Business Administration, MBA • Certified Nutritional Consultant, CNC 4 The New York Times Magazine, March 16, 2003 (pages 29-31) 5 Real health solutions, should be more certain than a coin flip… 6 7 Total Reported Adverse Reactions by year1 1,200,000 1,000,000 800,000 600,000 400,000 200,000 0 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 • Only 1% drug side effects are reported to the FDA in the USA2 • Hospital consultants report only 1 in 20 adverse drug reactions in the USA3 1. http://www.fda.gov/Drugs/GuidanceComplianceRegulatoryInformation/Surveillance/AdverseDrugEffects/ucm070434.htm 2. Scott HD, Rosebaum SE, Waters WJ, et al. Rhode Island Physicians’ recognition and reporting of adverse drug reactions RIMed J. 1987;70:311-316 3. David W. Bates, Drugs and Adverse Drug Reactions: How Worried Should We Be? JAMA.,1998; 279(15) : 1216-1217 8 Drug recalls 9 Pharmaceutical Withdrawn Reason for withdrawal from market Rofecoxib (Vioxx) 2004 Withdrawn from U.S. because risk of myocardial infarction and stroke Valdecoxib (Bextra) 2004 Withdrawn from U.S. because risk of heart attack and stroke Pemoline (Cylert) 2005 Withdrawn from U.S. because risk of hepatotoxicity (liver damage) Gatifloxacin 2006 Withdrawn from U.S. because increased risk of dysglycemia Ximelagatran (Exanta) 2006 Withdrawn worldwide because risk of hepatotoxicity (liver damage) Pergolide (Permax) 2007 Tegaserod (Zelnorm) 2007 Withdrawn from U.S. because risk of heart valve damage Withdrawn from the U.S. because risks of heart attack, stroke and unstable angina. Aprotinin (Trasylol) 2007 Withdrawn from the U.S. because risk of complications or death Lumiracoxib (Prexige) 2007–2008 2010 Risk of hepatotoxicity (liver damage) Withdrawn worldwide because of risk of severe depression and suicide Withdrawan worldwide because increased risk of heart attacks and stroke 2010 Withdrawn from the U.S. because of risk of cardiovascular disease 2010 2010 Withdrawn from the U.S. because lack of efficacy Increased risk of heart attacks and death. Drug continues to be available in the U.S. 2011 Withdrawn worldwide because lack of efficacy Rimonabant (Acomplia) Propoxyphene (Darvocet/Darvon) Sibutramine (Reductil/Meridia) Gemtuzumab ozogamicin (Mylotarg) 2008 Rosiglitazone (Avandia) Drotrecogin alfa (Xigris) 10 Medicine versus Poison • Med·i·cine: An agent used as a remedy to treat injury or cure a disease1 • Poi·son: A substance that causes injury, illness, or death, especially by chemical means1 Is it possible to convince a person that a poison can be a medicine? 1. http://www.thefreedictionary.com/ 11 Warfarin, aka Rat poison • In the early 1900’s, livestock owners, found animals died of hemorrhaging (uncontrolled internal bleeding) from consuming spoiled sweet clover hay • Scientists isolated the toxic substance (dicoumarol) and patented a synthetic form in 1948 to sell as a rodenticide (rat poison) • The use of warfarin itself as a rat poison is now declining, because many rat populations have developed resistance to it, and poisons of considerably greater potency are now available1 • Warfarin is the most widely prescribed oral anticoagulant drug in North America1 One person’s rat poison is another’s medicine 1. Systematic overview of warfarin and its drug and food interactions". Arch. Intern. Med. 165 (10): 1095–106 12 Chemotherapy, aka Nitrogen Mustard • The first patient in the United States was treated in December 1942, as discussed in a historical account of nitrogen mustard and the origin of chemotherapy1 • Mustard agents are usually classified as "blistering agents" owing to the similarity of the wounds caused by these substances resembling burns and blisters. However, since mustard agents also cause severe damage to the eyes, respiratory system and internal organs, they should preferably be described as "blistering and tissue-injuring agents"2 One person’s biochemical weapon is another’s medicine 1. Einhorn J. Nitrogen mustard: the origin of chemotherapy for cancer. Int J Radiat Oncol Biol Phys. 1985 Jul;11(7):1375-8. PubMed PMID: 3891698. 2. Ivarsson U, Nilsson H, Santesson J, eds. A FOA briefing book on chemical weapons: threat, effects, and protection. Umeå, National Defence Research Establishment, 1992. 13 International Agency for Research on Cancer • The International Agency for Research on Cancer (IARC) is part of the World Health Organization (WHO). Its major goal is to identify causes of cancer. The most widely used system for classifying carcinogens comes from the IARC. In the past 30 years, the IARC has evaluated the cancer-causing potential of more than 900 likely candidates, placing them into one of the following groups: Group 1: Carcinogenic to humans Group 2A: Probably carcinogenic to humans Group 2B: Possibly carcinogenic to humans Group 3: Unclassifiable as to carcinogenicity in humans Group 4: Probably not carcinogenic to humans One person’s cause of cancer is another’s cancer therapy http://monographs.iarc.fr/ENG/Monographs/suppl7/suppl7.pdf 14 (through 1964) 15 Whole Food Nutrition Pioneers 16 A Recipe for a Sicker Society Malnutrition Causes Disease & Degeneration Pharmaceutical Drugs Exacerbate malnutrition Pharmaceutical Drugs Cause Additional Disease 17 Over 61% of the adult population in the United States is on a prescription pharmaceutical drug.1 1. The U.S. Health System in Perspective: A Comparison of Twelve Industrialized Nations 18 Dr. Royal Lee One of the biggest tragedies of human civilization is the precedence of chemical therapy over nutrition. It's a substitution of artificial therapy over natural, of poisons over food, in which we are feeding people poisons trying to correct the reactions of starvation. You know how ridiculous this is. You all know how widely it is being done. Jan. 12, 1951 19 Medications & Supplements • Ask for current & PAST medications on your intake form – Duration – Dose, formulation, method of entry – Diagnosis – Lab work to support it – Brand & generic names • Ask for current & PAST supplements on your intake form – Duration, Dose, Purpose, Brand 20 Pharmaceutical References • Physician Desk Reference (PDR) • ePocrates® (www.epocrates.com) – Indications – Drug to Drug Interactions & ½ Life – Side Effect profile – Dosing – Additional: Mechanisms of Action (MOA) Additional • www.pubmed.gov 21 ePocrates.com Login onto Epocrates Online 22 1. Select ”Drugs” tab ePocrates.com 2. Search Drug by name 23 ePocrates.com 24 25 Methotrexate 26 Unveiling Adverse Events • Cross reference Adverse Events of medications with the checked off symptoms from the patient’s intake information 27 Pharmacology Excretion • Bile excretion • Urine excretion 28 Pharmacology (con’t) Metabolism • Involves the Cytochrome P450 (CYP450) Liver enzymes Sub·strate: the substance acted upon by an enzyme In·hib·i·tor: a substance that decreases the rate of or stops completely a chemical reaction In·duc·er: a substance that has the capability of activating a chemical reaction 29 Cytochrome P450 (CYP450) Enzymes Most widely studied Liver CYP450 enzymes are: • CYP1A2 • CYP2D6 • CYP3A4 • CYP2C9 • CYP2C19 30 Researching Pubmed Drugs are a very common cause of gynecomastia and should always be entertained as the possible cause of such a condition. Calcium channel blockers, captopril, digitalis glycosides, omeprazole, some antibiotics & growth hormone are all possibly, but less often, the responsible agent. 31 Case Study Example BP readings: Recumbent: 133/106 Pulse: 73 Standing: 141/111 Pulse: 85 5 Main Complaints: 1. Bowel movements takes work 2. Eczema 3. I sunburn too easily 4. Allergy to dairy 5. Gynecomastia Been taking Diltiazem® for 5 years. Swollen lymph glands. Vitamin D levels were at 31. Wife has history of gallstones. Initial 8 week protocol: Livaplex® (2x3) Calcium Lactate (2x3) Livton® Complex (2x3) Cataplex® F (1x3) Spanish Black Radish (2x3) Antronex® (1 per hour during allergy outbreaks) *Page Phase 1 Diet with Pasteurized Dairy Elimination 32 The Opportunity for COLLABORATION • A recent survey of 12,000 primary care physicians found that 66% of them were either less-than-satisfied or unsatisfied with the practice of medicine. 60% said they would not recommend medicine as a career. Approximately 1/3 of those who participated said they planned to stop seeing patients in the next 1-3 years and another 14 percent planned to cut back on patient care to part time. Tying in with this lack of job satisfaction, MDs also suffer from the highest rate of suicide among professionals. Many others are saddled by drug and alcohol addiction.1 1. DeVoe J, Fryer Jr GE, Hargraves JL, Phillips RL, Green LA. Does career dissatisfaction affect the ability of family physicians to deliver high-quality patient care? J Fam Pract. 2002 Mar; 51(3): 223-8. 33 Integrative Healthcare • Regular visits to the nutritionist, acupuncturist, and chiropractor remunerating each according to a fee-forservice model. Acupuncture • Partnered allopathic medical doctors titrate patients off unnecessary pharmaceuticals. • Catastrophic health care insurance available for times of need. Medication Elimination Whole Food Nutrition Chiropractic Emergency Medicine 34 The Pharmaceutical Myth • The complete guide for patients to finding their journey to optimal health and wellness • Part 1: The Pharmaceutical Myth includes 9 questions a patient must ask their allopathic medical doctor • Part 2: Food as Medicine includes 7 questions a patient must ask their holistic health care practitioner • Part 3: A New Hope includes 5 questions a patient must ask his or herself www.thepharmaceuticalmyth.com Münchausen syndrome by proxy • Münchausen Syndrome by Proxy (MSbP) is a label for a pattern of behavior in which care-givers deliberately exaggerate, fabricate, and/or induce physical, psychological, behavioral, and/or mental health problems in others When a mother feeds her child a low-dosed poison to induce illness, she is diagnosed with Münchausen Syndrome by Proxy. When the chemical industry does the same to a society, what is it called?... More importantly, what do WE do about it? 36 Action List To do 1st day back in the office 1. Update intake form to include questions asking for medications, bioidentical hormones, synthetic supplements - Ask if they are interested in improving their health, ultimately reducing their need or reliance for unecessary medications 2. Begin researching medications with www.epocrates.com & www.pubmed.gov 3. Identify 3 MD/NP/RN/PA’s to reach out and forge a referral partnership 37 Thank you for all the amazing work you do! 38 www.thehealingbody.com 39 Gerald Roliz, CNC, MBA 4000 Pimlico Dr. Suite 114-319 Pleasanton, CA 94568 cel: (510) 847-5733 off: (408) 915-8895 fax: (408) 645-7088 gerald@thehealingbody.com www.thehealingbody.com www.thepharmaceuticalmyth.com 40
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