1. No category

33
11
2013
11
Vol.33, No.11
Nov. 2013
doi: 10.7669/j.issn.0253-357X.2013.11.0765
E-mail: randc_journal@163.com
Reproduction & Contraception
(
,
-
(renin-angiotensin system, RAS)
,
:
;
-
-
RAS
RAS
(RAS);
: R711.5
1
RAS
AngII
,
Ang-(1-7)
AngI
,
)
2
AngII
; ACE2-Ang-(1-7)-Mas
RAS
[2-4]
Ang-(1-7),
(1-7)
,
Ang-
AT1 AT2
,
,
AT1
AT2
/
,
[5 ,6]
E-mail: 604500916@qq.com
Ang
AngII
AngII
(EMs)
; Tel: +86-311-66003768;
Fax: +86-311-66002023;
ACE2
AngII
ACE2
AngII
;
:
AngI
Ang-(1-7),
AngI
ACE-AngIIAT1/AT2
AngII
ACE
AngII
[1]
(
,
Ang-(1-7)
Mas
RAS,
[1,7-10]
RAS
(angiotensin-converting enzyme, ACE)
AT2
RAS
: 0253-357X(2013)11-0765-05
II(AngII)
2(ACE2)
,
,
;
:A
(renin-angiotensin system,
(renin)
,
;
RAS)
AT1
, 050000)
AT1
Mas
,
RAS
AT1
G
,
(GPCR)
Ang-(1-7)
A
765
(aminopeptidase A, APA)
(adipocyte-
derived leucine aminopeptidase, A-LAP)
, APA
(Zn)
AngII
,
;
;
,
,
;
, AngII
,
A-LAP
AngII
A-LAP
AngII
Mas
,
,
, A-LAP
AngII
APA
(renin)
2
,
RAS
AngII
APA
, RAS
,
,
;
APA
RAS
,
AngII
[11]
,
AngII
AngII
[3,11-13]
, AngII
AngII
,
,
APA
,
,
AngII,
AngII
[14,15]
,
, AngII
AngII
,
,
[12]
Ang
3
,
,
RAS
,
,
,
Ang
RAS,
,
,
AT2
,
,
,
,
AT1
[16]
AT1
AT2
,
,
ACE2
,
,
,
-
[17,18]
ACE
AT1
AngII
ACE
ACE-AngII-AT1/AT2
,
,
RAS
ACE
[13]
Ang-(1-7)
,
,
ACE
,
,
,
AT1
,
[3]
766
Ang-(1-7)
[19]
,
Ang-(1-7)
AT1,
Ang-(1-7)
,
,
AngII
ACE
Ang-(1-7)
AT2
,
,
;
AngII
AT1
AngII-ACE
, Ang-(1-7)-ACE2
,
[11]
,
ACE
AT1
,
[20]
Ang-(1-7)
4
RAS
RAS
,
ACE
AT1
,
RAS
,
,
EMs
[21]
AngII
RAS
Ang,
AT1
RAS
, ACE 2350*G
240*T
[27]
,
ACE-
[28]
EMs
, ACE A2350G
EMs
AT1,
RAS
AngII
,
, AT1
,
; Era
AT1
AT2
[31,32]
AngII
,
,
Ang
/
,
,
,
,
AT2
,
,
, Ang
,
,
APA
,
NEP
P-LAP
AT1
AngII
-1
,
p21
,
,
,
RAS
, AT2
,
RAS
,
5
RAS
,
,
[6,26-32]
3
APA, NEP P-LAP
,
AT2
,
AT2
/
AT2
[25]
, AT1
,
AT2
AT2
G2
VEGF
,
, AT1
;
, I
[29]
Ang
[1,8,9]
, G3
,
AngII
,
G1
G2
; G1
(VEGF)
(FGF)
, G3
( FIGO )
,
(Ang)
,
A-LAP
[30]
,
[24]
[29]
, A-LAP
,
:
VEGF
94
,
,
, A-LAP
AngII
, AngII
, EMs
, AngII
(HEC-1A)VEGF
A-240T
[23]
,
RAS
EMs
[22]
,
G
,
[21]
AngII
RAS
,
767
Hum Reprod, 1997, 12(3):2804-2.
[14] Shibata D, Ando H, Iwase A, et al. Distribution of adipocyte[1] Paul M, Poyan Mehr A, Kreutz R, et al. Physiology of local
derived leucine aminopeptidase (A-LAP)/ER-aminopepti-
renin-angiotensin systems. Physiol Rev, 2006, 86(3):747-
dase (ERAP)-1 in human uterine endometrium. J Histochem
803.
Cytochem, 2004, 52(9):1169-75.
[2] Johnson IR. Renin substrate, active and acid-activatable renin
[15] Ando H, Nagasaka T, Nomura M, et al. Premenstrual disap-
concentrations in human plasma and endometrium during
pearance of aminopeptidase A in endometrial stromal cells
the normal menstrual cycle. Br J Obstet Gynaecol, 1980, 87
around endometrial spiral arteries/arterioles during the de-
(10):875-82.
cidual change. J Clin Endocrinol Metab, 2002, 87(5):2303-9.
[3] Vaz-Silva J, Carneiro MM, Ferreira MC, et al. The vasoactive
[16] Schrier RW, Ohara M. Dilemmas in human and rat pregnancy:
peptide angiotensin-(1-7), its receptor Mas and the angio-
proposed mechanisms relating to arterial vasodilation. J
tensin-converting enzyme type 2 are expressed in the human
Neuroendocrinol, 2010, 22(5):400-6.
endometrium. Reprod Sci, 2009, 16(3):247-56.
,
[4]
,
.
2(ACE2)-
(Ang)-(1-7)-MAS
.
, 2011, 31(10):691-4.
[17]Brosnihan KB, Bharadwaj MS, Yamaleyeva LM, et al.
Decidualized pseudopregnant rat uterus shows marked reduction in Ang II and Ang-(1-7) levels. Placenta, 2012, 33(1):
17-23.
[5] Mala C, John AD, Vesta SL, et al. Variationin the rennin
[18] Valdes G, Corthorn J, Bharadwaj MS. Utero-placental expres-
angiotensin system throughout the normal menstrual cycle.
sion of angiotensin-(1-7) and ACE2 in the pregnant guinea-
J Am Soc Nephrol, 2002, 13(2):446-52.
pig. Reprod Biol Endocrinol, 2013, 11(1):5.
[6] Shibata K, Klikkawa F, Mizokami Y, et al. Possible involve-
[19] Joyner J, Neves LA, Granger JP, et al. Temporal-spatial
ment of adipocyte-derived leucine aminopeptidase via an-
expression of ANG-(1-7) and angiotensin-converting enzyme
in endometrial carcinoma. Tumour Biol, 2005, 26
2 in the kidney of normal and hypertensive pregnant rats.
giotensin
(1):9-16.
[7] Keidar S, Kaplan M, Gamliel-Lazarovich A. ACE2 of the heart:
from angiotensin I to angiotensin (1-7). Cardiovasc Res, 2007,
73(3):463-9.
[8] Wright JW, Yamamoto BJ, Harding JW. Angiotensin
Am J Physiol Regul Integr Comp Physiol, 2007, 293(1):
R169-77.
[20] Neves LA, Stovall K, Joyner J, et al. ACE2 and ANG-(1-7)
in the ratuterus during early and late gestation.Am J Physiol
Regul Integr Comp Physiol, 2008, 294(1):R151-6.
receptorsubtype mediated physiologies and behaviors new
[21] Abraham F, Sacerdoti F, De Len R, et al. Angiotensin II activates
discoveriesand clinical targets. Prog Neurobiol, 2008, 84 (2):
the calcineurin/NFAT signaling pathway and induces
157-81.
cyclooxygenase-2 expression in rat endometrial stromal cells.
[9] Vongpatanasin W, Thomas GD, Schwartz R, et al. Creactive
Rev Assoc Med Bras, 2012, 58(5):620-32.
protein causes downregulation of vascular angiotensin sub-
[22] Hsieh YY, Chang CC, Tsai FJ, et al. Angiotensin I-converting
type receptors and systolic hypertension in mice. Circulation,
enzyme ACE 2350*G and ACE-240*T-related genotypes
2007, 115(8):1020-8.
and alleles are associated with higher susceptibility to
[10] Alenina N, Xu P, Rentzsch B, et al. Genetically altered animal
models for Mas and angiotensin-(1-7). Exp Physiol, 2008,
93(5):528-37.
endometriosis. Mol Hum Reprod, 2005, 11(1):1-4.
[23] Hsieh YY, Chang CC, Chen SY, et al. XRCC1 399 Arg-related
genotype and allele, but not XRCC1 His107Arg, XRCC1
[11] Ahmed A, Li XF, Shams M, et al. Localization of the
Trp194Arg, KCNQ2, AT1R, and hOGG1 polymorphisms,
angiotensin II and its receptor subtype expression in human
are associated with higher susceptibility of endometriosis.
endometrium and identification of a novel high-affinity an-
Gynecol Endocrinol, 2012, 28(4):305-9.
giotensin II binding site. J Clin Invest, 1995, 96(3):848-57.
[24] Touyz RM. Molecular and cellular mechanisms in vascular
[12] Li XF, Ahmed A. Dual role of angiotensin II in the human
injury in hypertension: role of angiotensin II. Curr Opin
endometrium. Hum Reprod, 1996, 11(Suppl 2):95-108.
Nephrol Hypertens, 2005, 14(2):125-31.
[13] Li XF, Ahmed A. Compartmentalization and cyclic variation
[25] Li XF, Ahmed A. Expression of angiotensin II and its receptor
of immunoreactivity of renin and angiotensin converting en-
subtypes in endometrial hyperplasia: a possible role in dys-
zyme in human endometrium throughout the menstrual cycle.
functional menstruation. Lab Invest, 1996, 75(2):137-45.
768
[26] Kinoshita J, Fushida S, Harada S, et al. Local angiotensin II-
(1):9-16.
generation in human gastric cancer: correlation with tumor
[30] Piastowska-Ciesielska AW, Puciennik E, Wojcik-Krowiranda
progression through the activation of ERK1/2, NF-kappaB
K, et al. Analysis of the expression of angiotensin II type 1
and survivin. Int J Oncol, 2009, 34(6):1573-82.
receptor and VEGF in endometrial adenocarcinoma with dif-
[27] Ino K, Shibata K, Yamamoto E, et al. Role of the reninangiotensin system in gynecologic cancers. Curr Cancer Drug
ferent clinicopathological characteristics. Tumour Biol, 2012,
33(3):767-74.
[31] Kikkawa F, MizunoM, Shibata K, et al. Activation of inva-
Targets, 2011, 11(4):405-11.
[28] Watanabe Y, Shibata K, Kikkawa F, et al. Adipocyte-derived
leucine aminopeptidase suppresses angiogenesis in human
endometrial carcinoma via renin-angiotensin system. Clin
Cancer Res, 2003, 9(17):6497-503.
[29] Shibata K, Kikkawa F, Mizokami Y, et al. Possible involvement of adipocyte-derived leucine aminopeptidase via an-
siveness of cervical carcinoma cells by angiotensin
. Am J
Obstet Gynecol, 2004, 190(5):1258-63.
[32] Ino K, Shibata K, Kajiyama H, et al. Angiotensin II type 1
receptor expression in ovarian cancer and its correlation with
tumour angiogenesis and patient survival. Br J Cancer, 2006,
94(4):552-60.
giotensin II in endometrial carcinoma. Tumour Biol, 2005, 26
(2013
4
22
)
Local Renin-angiotensin System in Endometrium
Yu-mei MA, Wei JIANG, Jie-ying ZHANG
(Department of Pathology, the Second Hospital of Hebei Medical University, Shijiazhuang, 050000)
ABSTRACT
Renin-angiotensin system (RAS) is an important humoral regulation system in human body, the
disorder of this system could induce many diseases. Many previous studies focus on this circulating RAS system,
local RAS becomes a research hotspot these years. Related studies have shown that local RAS participates in a
series of physiological processes such as endometrial periodic changes, reproductive function regulation, and
pregnant uterine body homeostasis. And local RAS also participates in the pathological process such as
endometriosis (EMs), functional endometrial bleeding and endometrial cancer.
Key words: renin-angiotensin system (RAS); angiotensin; angiotensin receptor; endometrium
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