1. No category

UHID
Research
Groups
January 2010
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PREFACE
For centuries infectious diseases have threatened mankind, and on many occasions they
have changed history profoundly. Today, infectious diseases continue to pose enormous
challenges to human well being and medical science worldwide. While antibiotics, novel
therapeutics, vaccines, new genetic analyses, and sensitive diagnostic procedures have
improved our ability to prevent, treat, and control infectious diseases, their elimination will
occur only through extensive, collaborative national and international biomedical and
public health research.
The University Hospital for Infectious Diseases (UHID) is the leading infectious disease
clinical and research facility in Croatia and the region. Its infectious disease focus is
unique and provides the ability to manage patients harboring a wide variety of pathogens,
conduct research with modern diagnostic and analytical tools, teach undergraduate
students, and train postgraduate nursing and clinical specialists. This brochure is intended
to briefly inform readers about the members and activities of the research groups at the
UHID. The experts at UHID would be honored to discuss potential collaborations on
infectious disease challenges with colleagues worldwide.
Recently, thanks to the support of the Croatian Ministry of Sciences, Education and
Sports, a Central Diagnostic Laboratory and the first Croatian Biosafety Level 3 and
Biosafety Level 2+ Laboratory were constructed at the UHID. These laboratories will
facilitate the involvement of UHID scientists in collaborative projects. In addition, the
Ministry has supported the employment of 14 new PhD students at the Infectious Disease
Clinic, guaranteeing future clinical and research expertise.
In keeping with the longstanding mission of the UHID, its experts participate in many
national and international projects. This brochure describes some of the clinical and basic
research activities of UHID scientists in different areas including: Nosocomial Infections,
Endocarditis, HIV/AIDS, Hepatitis B,C,E, Papillomaviruses, Sexually Transmitted
Infections, Urinary Tract Infections, Respiratory Tract Infections (emphasis on Flu),
Antimicrobial Therapy and Resistance, Pediatric Infections / Diseases, Infections in the
Immunocompromised, Imunopathogenesis of Infections, Emerging and Re-emerging
Infectious Diseases, and Tropical / Parasitic diseases.
Modern UHID infectious disease research will build on a tradition of success. For example,
some human infectious diseases were discovered by UHID scientists.
a. Human infection with Bhanja virus.
Vesenjak-Hirjan J, Calisher CH, Beus I, Marton E. First natural clinical human Bhanja virus
infection. Zentralblatt fur Bakteriologie, Mikrobiologie und Hygiene. I. Abt. 1980; (suppl.
9):297-301. (Vesenjak-Hirjan J, Porterfield JS, Arslanagić E, editors. Arboviruses in the
Mediterranean countries. 6th FEMS Symposium. Supetar, Brač, 1978)
b. Human infection with Eperythrozoon
Puntaric V, Borcic D, Vukelic D, Jeren T, Burek V, Wikerhauser T, Richter B.
Eperythrozoonosis in man. Lancet 1986: 2(8511):868-9.
c. Human infection with Grahamella
Puntaric V, Borcic D, Bejuk D, Vrhovec B, Madic J, Busch K, Richter B. Haemotropic
bacteria in man. Lancet 1994;343(8893):359-60.
Professor Alemka Markotić, MD, PhD
Head, Research Department
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Facts about the University Hospital for Infectious Diseases "Dr. Fran Mihaljević"
Zagreb, Croatia
www.bfm.hr
The University Hospital for Infectious Diseases (UHID) is affiliated with the University of
Zagreb Medical School and is the leading institution for the treatment of infectious
diseases in Croatia. This tertiary care provider treats over 8,000 inpatients and 65,000
outpatients per year. Most patients are from Zagreb, but many are referred to the UHID
from throughout Croatia and neighboring countries.
History
The University Hospital for Infectious Diseases was founded in the Spring of 1893 as The
City Hospital for Contagious Diseases (CHCD). The impetus for the facility was the
increase of rapid travel in the late 19th century and the increased the risk for disease
transmission associated with the movement of people and goods. For example, the spread
of cholera through Europe and the Middle East presented great dangers to Croatia and its
neighbors. Gradually, the CHCD grew larger and admitted patients with classical infectious
diseases (diphtheria, scarlet fever, typhus exanthematicus, etc.). During the First World
War, the CHID had 800 beds, and served as civilian and a military hospital. In 1914, the
CHID had a primitive laboratory for the basic analysis of blood and urine. However, thanks
to the work of two distinguished clinicians, Dr. Steinhardt and Dr. Fran Mihaljević, the
UHID grew rapidly between 1920-30. (The UHID was named after Dr. Mihaljević in 1978).
In the 1950s hospital buildings were reconstructed and new buildings and wards were
established, including the first intensive care unit in Croatia. The UHID hospital became
affiliated with the Medical School of theUniversity of Zagreb in 1956 with the establishment
of the Department for Infectious Diseases. This Department has trained undergraduates,
postgraduates and medical students for more than fifty years. Laboratory and diagnostic
medicine capabilities developed rapidly in the 1970 and now include modern immunologic
and molecular medicine procedures. Rapid advances in research programs in many areas
of infectious disease have occurred in the past 20 years.
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Management structure
Capacity
232 beds (172 for adults, 60 for children)
Inpatients – 8,000 /year
Outpatients – 65,000 /year
Average daily census – 211 (162 adults, 49 children)
Average length of stay (days) – 10.52
Catchment Area
Approximately 1 million, the population of Zagreb. Croatia has a total population of 4.3 mil.
Staff
Total
Medical Staff
MD, specialists in infectious
diseases
MD, specialists in microbiology,
epidemiology, radiology,
cytology
Residents in infectious diseases
PhD students
BSc degree (clinical
biochemistry, molecular biology,
pharmacy, etc.)
Medical nurses, technicians
Administrative
and other non-medical staff
Total
4
415
46
Full
time
374
46
Part
time
41
-
9
9
-
5
14
16
5
14
16
-
329
228
288
228
41
-
643
602
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Medical services
Clinical Departments and Divisions
Clinical Department for Acute Respiratory Infections
Clinical Department for Urinary Tract Infections
Clinical Department for Gastrointestinal Infections
Clinical Department for Viral Hepatitis
Clinical Department for Infections in the Immunocompromised
Clinical Department for Adult Intensive Care and Neuroinfections
Clinical Department for Pediatric Infectious Diseases
Division for Newborns and Infants
Division for Young Children with PICU
Division for Preschool and School Children
Clinical Department for Exanthematous Diseases
Clinical Department for General Infectious Diseases
Department for Radiology and Ultrasound Diagnostics
Emergency Department
Research Department
Pharmacy
Medical Records Department
Outpatient departments:
Central Admissions Department - Day Hospital – Patients arriving for first examination
Polyclinics - Follow-up visits of previously hospitalized patients
Reference Centers of The Ministry of Health and Social Welfare
Reference Center for Diagnostics and Treatment of Infectious Diseases
Reference Center for Diagnostics and Treatment of Viral Hepatitis
Reference Center for Diagnostics and Treatment of HIV-infection
Reference Center for Urinary Tract Infections
Reference Center for Antibiotic Resistance Surveillance
Reference Center for Tropical and Traveler Diseases
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Central Diagnostic Laboratory (CDL)
New facility constructed and equipped for Clinical Laboratory Diagnostics:
Department for Clinical Microbiology
Division of Bacteriology and Hospital Infections
Division of Virology
Division of Parasitology
Department of Clinical Immunology
Department of Medical Biochemistry
Department of Diagnostic Hematology and Cytology
Department of Molecular Diagnostics and Flow Cytometry
The CDL Facility includes this new Biosafety Level 3 (BSL-3) Laboratory with Cell
Culture Unit (Research Department) and BSL-2+ Laboratory for Prion Diseases.
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Educational activities
The University Hospital for Infectious Diseases is a teaching hospital for:
- Undergraduate and Postgraduate students of Medicine (Department for Infectious
Diseases of the University of Zagreb Medical School)
- Students of Dental Medicine (Department for Infectious Diseases of the University
of Zagreb School of Dental Medicine),
- Medical doctors specializing in other medical fields - Clinical Microbiology,
Epidemiology, Internal Medicine, Neurology, Pediatrics, etc., (Department for
Infectious Diseases of the University of Zagreb Medical School)
- Medical nurses and technicians (University of Applied Health Studies, Zagreb,
Croatia).
Professional Societies of The Croatian Medical Association affiliated with UHID
Croatian Society for Infectious Diseases (incl. Section for Respiratory Tract Infections)
Croatian Society of Chemotherapy
Croatian Society of Urogenital and Sexually Transmitted Infections (incl. Section for
Chlamydia trachomatis, Section for Human Papillomavirus)
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Principal investigator
Professor Bruno Baršić, MD, PhD
Research team
Assistant Professor Suzana Bukovski, MD, PhD
Dragan Lepur, MD
PhD or postdoctoral students
Marko Kutleša, MD, Marija Santini, MD, Ana Pangerčić, MD, Vladimir Krajinović, MD
Address
Intensive Care Unit, University Hospital for Infectious Diseases, Mirogojska 8, Zagreb,
Croatia, tel. ++385 91 4012604, fax. ++385 1 2826 255; e-mail: bbarsic@bfm.hr
Research topics
1. Antimicrobial and other adjunctive therapy of critically ill infectious disease patients
a. Hypothermia in patients with bacterial and viral meningoencephalitis
Patients with low GCS and reduced CO2 reactivity measured by transcranial doppler are
included and subdued to hypothermia (33 0C) for 4 days. Measurements of cerebral blood
flow and optic nerve diameter, as well as lactate index are performed daily. Outcome>:
Glasgow Outcome Score
b. Timing of appropriate antibiotic treatment of ICU acquired blood stream infections
Evaluation of outcome of ICU treatment regarding timing of appropriate antimicrobial
treatment particularly in patients with nosocomial blood stream infections.
c. Are glycopetides still the best choice for the treatment of MRSA infections?
Observational study including patients with S. aureus infection. Correlation of outcome
with vancomycin MIC values. Comparison of vancomycin with other antibiotics (linezolid,
daptomycin).
2. Infective Endocarditis
a. Influence of early cardiac surgery on patients’ outcome
Observational study in patients with definite IE – comparison of outcome between early
surgery groups (within 14 days from diagnosis) with no surgery or postponed surgery.
b. Factors associated with development of endocarditis during staphylococcxal blood
stream infection
Observational study including patients with staphylococcal bacteremia. Comparing
patients with endocarditis and no endocarditis regarding cardiac diseases, and permanent
use of statins, acetylsalicylic acid, anticoagulants.
Ongoing or previous national projects
Nosocomial infections in ICU (previous)
Therapeutic aspects of care for critically ill patient
Ongoing or previous international projects
International Collaboration on Endocarditis (ICE) – Duke Medical Research Centre, Durham,
NC, Ralph Correy – Principal Investigator
EPIC II Study – Erasmus University Brussels – Jean Louis Vincent, Principal Investigator
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Collaboration with international institutions
Duke Research Center (ICE Study)
Teaching and educational involvement
School of Medicine Zagreb (Chair of the Department for Infectious Diseases)
International research experience and study visits
Mary Hitchcock Memorial Hospital Lebanon, NH
Selected publications
1. Santini M, Kutlesa M, Pangercic A, Barsic B. The importance of pathogens in sepsis:
Staphylococcus aureus story. Scand J Infect Dis. 2009 [Epub ahead of print]
2. Kutlesa M, Lepur D, Daković-Rode O, Schoenwald N, Barsic B. Severe late-onset
nosocomial pneumonia caused by Chlamydophila pneumoniae. Acta Clin Croat 2009
Jun;48(2):179-82.
3. Bae IG, Federspiel JJ, Miró JM, Woods CW, Park L, Rybak MJ, Rude TH, Bradley S,
Bukovski S, de la Maria CG, Kanj SS, Korman TM, Marco F, Murdoch DR, Plesiat P,
Rodriguez-Creixems M, Reinbott P, Steed L, Tattevin P, Tripodi MF, Newton KL, Corey
GR, Fowler VG Jr; International Collaboration on Endocarditis-Microbiology
Investigator. Heterogeneous vancomycin-intermediate susceptibility phenotype in
bloodstream methicillin-resistant Staphylococcus aureus isolates from an international
cohort of patients with infective endocarditis: prevalence, genotype, and clinical
significance. J Infect Dis 2009;200(9):1355-66.
4. Lepur D, Barsic B. Incidence of neurological complications in patients with native-valve
infective endocarditis and cerebral microembolism: an open cohort study. Scand J
Infect Dis. 2009;41(10):708-13.
5. Durante-Mangoni E, Bradley S, Selton-Suty C, Tripodi MF, Barsic B, Bouza E, Cabell
CH, Ramos AI, Fowler V Jr, Hoen B, Koneçny P, Moreno A, Murdoch D, Pappas P,
Sexton DJ, Spelman D, Tattevin P, Miró JM, van der Meer JT, Utili R; International
Collaboration on Endocarditis Prospective Cohort Study Group. Current features of
infective endocarditis in elderly patients: results of the International Collaboration on
Endocarditis Prospective Cohort Study. Arch Intern Med. 2008;168(19):2095-103.
6. Vince A, Lepej SZ, Barsic B, Dusek D, Mitrović Z, Serventi-Seiwerth R, Labar B.
LightCycler SeptiFast assay as a tool for the rapid diagnosis of sepsis in patients
during antimicrobial therapy. J Med Microbiol. 2008;57(Pt 10):1306-7.
7. Kutlesa M, Lepur D, Bukovski S, Lepur NK, Barsic B. Listeria monocytogenes
meningitis associated with rhabdomyolysis and acute renal failure. Neurocrit Care
2009;10(1):70-2.
8. Barsic B, Beus I, Marton E, Himbele J, Klinar I. Nosocomial infections in critically ill
infectious disease patients: results of a 7-year focal surveillance. Infection.
1999;27(1):16-22.
9. Meissner B, Kallenberg K, Sanchez-Juan P, Ramljak S, Krasnianski A, Heinemann U,
Eigenbrod S, Gelpi E, Barsic B, Kretzschmar HA, Schulz-Schaeffer WJ, Knauth M,
Zerr I. MRI and clinical syndrome in dura mater-related Creutzfeldt-Jakob disease. J
Neurol 2009;256(3):355-63.
10. Krajinović V, Tambić Andrasević A, Barsic B. Tricuspidal valve endocarditis due to
Yersinia enterocolitica. Infection 2007;35(3):203-5.
Other related web-links (personal web-sites, PubMed references, CROSBI or similar)
http://tkojetko.irb.hr/znanstvenikDetalji.php?sifznan=2888
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Principal investigator
Professor Josip Begovac, MD, PhD
Research team
Klaudija Višković, MD, PhD, Specialist in Radiology
Miroslav Lisić, MD, PhD, Associate Professor of Infectious Diseases
Davorka Lukas, MD, PhD, Assistant Professor of Infectious Diseases
Drago Turčunov, MD, PhD
Šime Zekan, MD
PhD or postdoctoral students
Kozić Sanja, BSc
Djaković-Rode Oktavija, MD
Marta Perović, MD
Address
HIV/AIDS Center, University Hospital for Infectious Diseases, Mirogojska 8, Zagreb, Croatia
tel. ++385 1 2826 150; fax. ++385 1 4678 235, e-mail: jbegovac@bfm.hr
Research topics
HIV/AIDS, Lipodystrophy, Dyslipidemia, Mediterranean diet, Streptococcal infections
Ongoing or previous national projects
Epidemiological, clinical and laboratory features of HIV infection in the era of highly active
antiretroviral treatment (HAART) in patients from Croatia
Ongoing or previous international projects
EUROSIDA
Collaboration with international institutions
Institute for Global Health, University of San Francisco
Teaching and educational involvement
Infectious diseases, University of Zagreb Medical School
International research experience and study visits
1996 Dartmouth Medical Center, USA
2003 Institute for Global Health, University of San Francisco
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Selected publications
1. Begovac J, Marton E, Lisic M, Beus I, Bozinovic D, Kuzmanovic N. Group A betahemolytic streptococcal toxic shock-like syndrome. Pediatr Infect Dis J 1990;9:369-370.
2. Begovac J, Bobinac E, Benic B, Desnica B, Maretic T, Basnec A, Kuzmanovic N.
Asymptomatic pharyngeal carriage of beta-haemolytic streptococci and streptococcal
pharyngitis among patients at an urban hospital in Croatia. Eur J Epidemiol 1993;9:405410.
3. Begovac J, Jeren T, Kuzman I, Jukic V, Ravlic Z, Andrasevic S. Health status of 1458
Croatian prisoners of war, 1991-1992. JAMA 1993;270:574-575.
4. Begovac J, Kuzmanovic N, Bejuk D. Comparison of clinical characteristics of group A
streptococcal bacteremia in children and adults. Clin Infect Dis 1996;23:97-100.
5. Bace A, Zrnic T, Begovac J, Kuzmanovic N, Culig J. Short-term treatment of pertussis with
azithromycin in infants and young children. Eur J Clin Microbiol Infect Dis 1999;18:296298.
6. Schonwald S, Begovac J, Skerk V. Urinary tract infections in HIV disease. Int J Antimicrob
Agents 1999;11:309-311.
7. Begovac J, Mihaljevic I, Perrin L. HIV-1 and HCV infections among antibody-negative
blood donors. N Engl J Med 2004;351:2232-2235; author reply 2232-2235.
8. Rode OD, Lepej SZ, Begovac J. Low seroprevalence of human herpesvirus 8 infection in
Croatia. Clin Infect Dis 2005;40:1208.
9. Begovac J, Zekan A, Skoko-Poljak D. Twenty years of human immunodeficiency virus
infection in Croatia-an epidemic that is still in an early stage. Coll Antropol 2006;30 Suppl
2:17-23.
10. Zekan S, Novotny TE, Begovac J. Unsafe sexual behavior among HIV-infected patients in
Croatia, 2006: prevalence and associated factors. AIDS Behav 2008;12:S86-92.
11. Turcinov D, Stanley C, Canchola JA, Rutherford GW, Novotny TE, Begovac J.
Dyslipidemia and adherence to the Mediterranean diet in Croatian HIV-infected patients
during the first year of highly active antiretroviral therapy. Coll Antropol 2009;33:423-430.
12. Turcinov D, Stanley C, Rutherford GW, Novotny TE, Begovac J. Adherence to the
Mediterranean diet is associated with a lower risk of body-shape changes in Croatian
patients treated with combination antiretroviral therapy. Eur J Epidemiol 2009;24:267-274.
13. Bozicevic I, Rode OD, Lepej SZ, Johnston LG, Stulhofer A, Dominkovic Z, Bacak V, Lukas
D, Begovac J. Prevalence of sexually transmitted infections among men who have sex
with men in Zagreb, Croatia. AIDS Behav 2009;13:303-309.
Other related web-links (personal web-sites, PubMed references, CROSBI or similar)
http://bib.irb.hr/lista-radova?autor=143475&period=2007
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Principal investigator
Professor Antun Beus MD, PhD
Director, UHID
Other key personnel
From UHID:
Boško Desnica, MD
Jasminka Granić, DVM, MSc
Nina Vicković, MD, MSc
Mirjana Balen Topić, MD, MSc
Nikola Makek, MD
From collaborative institutions_
Professor Dagny Stojčević, DVM, PhD, School of Veterinary Medicine, University of Zagreb
Professor Ivan Drinković, MD, PhD, Medical School, University of Zagreb
Address
Office of Director, Department for gastrointestinal diseases and parasitic diseases
University Hospital for Infectious Diseases, Mirogojska 8, Zagreb, Croatia
tel. ++385 1 2826 222
fax. ++385 1 4678 235
e-mail: antun.beus@mef.hr
Research topics
Echinococcosis therapy
Parasitic diseases
Tropical and travel medicine
Ongoing or previous national projects
2006-present Determination of the most effective echinococcosis therapy, funded by The
Croatian Ministry of Science, Education and Sport
Ongoing or previous international projects
2004-2009- MetaNET-SEE – Netzwerk akademischer Netzwerke, University Bielefeld,
Germany
International research experience and study visits
1980 – Tropical and travel medicine – Mexico City, Mexico
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Selected publications
1: Markotić A, Skerk V, Cvetko Krajinović L, Beus A. Is the clinical picture of
Schnitzler syndrome always Schnitzler syndrome? Clin Exp Rheumatol. 2009;27(3):507-9.
2: Desnica B, Beus A, Skuhala T, Topic MB, Vickovic N, Makek N. Myalgia and
swelling of interphalangeal joints as side-effect of prolonged azithromycin
therapy in patient with pelvic actinomycosis: case report. Scand J Infect Dis.
2007;39(2):186-7.
3: Topic A, Skerk V, Puntaric A, Milavec Puretic V, Beus A, Begovac J.
Azithromycin: 1.0 or 3.0 gram dose in the treatment of patients with asymptomatic
urogenital chlamydial infections. J Chemother. 2006 Feb;18(1):115-6.
4: Puljiz I, Beus A, Kuzman I, Seiwerth S. Electrocardiographic changes and
myocarditis in trichinellosis: a retrospective study of 154 patients. Ann Trop
Med Parasitol. 2005 Jun;99(4):403-11.
5: Skerk V, Schönwald S, Krhen I, Markovinović L, Beus A, Kuzmanović NS, Kruzić
V, Vince A. Aetiology of chronic prostatitis. Int J Antimicrob Agents. 2002
Jun;19(6):471-4.
6: Skerk V, Schönwald S, Strapac Z, Beus A, Francetić I, Krhen I, Lesko V,
Vuković J. Duration of clinical symptoms in female patients with acute urethral
syndrome caused by Chlamydia trachomatis treated with azithromycin or
doxycycline. J Chemother. 2001 Apr;13(2):176-81.
7: Skerk V, Schönwald S, Strapac Z, Beus A, Francetić I, Krhen I, Lesko V,
Vukovic J. Duration of clinical symptoms in female patients with acute urethral
syndrome caused by Ureaplasma urealyticum treated with azithromycin or
doxycycline. J Chemother. 2000 Dec;12(6):533-5.
8: Lukas D, Beus A. [Cholera threatens again]. Lijec Vjesn. 1994
Jul-Aug;116(7-8):169-74. Croatian.
9: Beus A. [Comparative study of thiabendazole and mebendazole in
strongyloidiasis]. Lijec Vjesn. 1989 Mar;111(3):98-101.
Other related web-links (personal web-sites, PubMed references, CROSBI or similar)
http://bib.irb.hr/lista-radova?autor=61516&period=2007
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Principal investigator
Professor Vitomir Burek, MD, PhD
Research team
Jadranka Horvat
Cvrlje Vesna
Banić Marko
Grgurević Ivica
Professor Ranko Ostojić, MD, PhD
Židovec-Lepej, PhD
Mikulić Radojka
Address
Department for Clinical Immunology, University Hospital for Infectious Diseases, Mirogojska 8,
10000 Zagreb, Croatia, tel: ++385 1 2826 162; fax: ++385 1 2826 151
e-mail: vitomir.burek@bfm.hr
Research topics
Viral hepattis C, B, coinfection B/C in the general population and selected populations in
Croatia
HIV infection
Ongoing or previous national projects
Immunologic aspects of viral hepatitis, Ministry of Science Republic of Croatia
Transmission of hepatitis B virus from mother asymptomatic carrier of Hepatitis Bs antigen to
newborn child, Ministry of Science Republic of Croatia
Immunologic characteristics of HIV infected individuals, Ministry of Science Republic of
Croatia
Ongoing or previous international projects
Vertical transmission of hepatitis B virus, consequences and possibility of protection,
NIH (National Institutes of Health), Bethesda, USA, 1985-1987, Foreign Research Agreement
No. JFP 611 US Department of Health, Education and Welfare, Public Health Service
Collaboration with international institutions
1. Max von Pettenkofer Institut, University of Munich, Germany
Viral hepatitis
Gürtel Gerhard
2. Biomedical Research Center, Immuno, Wiena, Austria
HIV infection
Gerencer Marijan
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International research experience and study visits
Study visit: Poland: Warsaw-Higienic Institute, Infective Clinic: Poznan-Infective Clinic
Study visit: London Radioisotopic and Labelled Reagent Microanalytical Methods, Medical
School
Study visit: Washington/ Bethesda (National Institute of Health – NIH), USA
Study visit: Atlanta, Center for Disease Control – CDC, USA
Study visit: Viena, Universität Klinik, Viena, Austria
Study visit: Paris, 1 eres Recontres Europeennes Est-Quest Toxicomanie, France
Study visit: Viena, Universitat Klinik, Viena, Austria
Study visit: Salluga, (Research center, Salluga), Italiy.
Study visit: Gottingen, George-August-Universitat, Klinik fur Neurologie, CJDForschungsgruppe), Germany
Selected publications
1. Burek V, Plavljanić Đ, Šlamberger S, Vitale B. Studies on the mechanism of allogeneic
disease in mice. The influence of bone marrow T lymphocytes on the differentiation and
proliferation of hemopoietic stem cells. Exp Hemat 1977;5:465-479.
2. Vitale B, Burek V, Plavljanić Đ. Influence of T lymphocytes on the process of differentiation
and proliferation of bone marrow cells. Transplant Proc 1977;9:269-272.
3. Burek V, Baće A, Kačić M, Belošević, Mravunac B. Prevalence of antibodies to hepatitis A
virus among urban children aged 0 - 7 years in Yugoslavia. J Infect 1985;10:71-75.
4. Burek V, Hudolin V, Sakoman S, Kovač D, Ficović F, Čepelja S, Petričević I, Schonwald S,
Soldo I, Borčić D. HTLV-III antibody in Yugoslav members of high risk groups for AIDS. Period
Biol 1986;88:68-69.
6. Burek B, Burek V, Košutić Z. Local Xenogeneic Graft-Versus-Host Reaction: A Measure of
T-Cell Function in Asymptomatic HBsAg Carriers. J Clin Lab Immunol 1988;27:69-72.
7. Burek V, Mišić-Mayerus LJ, Maretić T. Antibodies to Borrelia burgdorferi in Various
Population Groups in Croatia. Scand J Infect Dis 1992;24:683-684.
8. Burek V, Gerenčer M. Inhibition of Classical Complement Activation by Sera From HIV-1
Positive Patients. Clin Immunol Immunopathol 1996;81(2):114-121.
9. Gerenčer M, Burek V, Barett NP, Dorner F. Acquired Eficiency of Functional C1 Esterase
Inhibitor in HIV Type 1 – Infected Patients. J AIDS Res Hum Retrovirus 1997;13(10):813-815.
10. Gerenčer M, Burek V, Crowe BA, Barett np, Dorner F. The role of complement and gp
120-specific antibodies in virus lysis and CD4+ T cell depletion in HIV-1-infected patients.
Microb Pathogen 1998;25(5):252-266.
11. Burek V, Mikulić R. Reappearance of free HCVAg after immunosuppression with decrease
of anti-HCV spectrum. Irish J Med Sci. 2003;172:13.
12. Burek V, Mikulić R. HCV core antigen and the time of HCV infection. Int J Infect Dis. S42,
2004.
13. Gerenčer M, Burek V. Identification of HIV-1 proteaze cleavage site in human C1-inhibitor.
Virus Res 2004;105:97-100.
14. Romic Z, Derek L, Burek V, Petrovecki M, Unic A. Anty-cyclic citrullinated peptide and
rheumatoid factor in HIV positive patients. J Clin Laborat Anal 2009. (in press)
15. Burek V, Horvat J, Butorac K, Mukulic R. Viral Hepatitis B, C and HIV infection in Croatian
prisons. Epidemiology and Infection 2009. (in press)
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Principal investigator (group leader)
Professor Ilija Kuzman, MD, PhD
Research team
Ivan Puljiz, MD,PhD
Oktavija Đaković-Rode, MD, MSc
Professor Alemka Markotić, MD, PhD
Neala Schoenwald, MD, PhD
Klaudija Višković, MD, PhD
Renata Laškaj, PhD
PhD student: Tomislava Skuhala, MD
Address
Department for Respiratory Tract Infections, University Hospital for Infectious Diseases,
Mirogojska 8, 10 000 Zagreb, Croatia, tel: ++385 1 2826 118; fax: ++385 1 4578 235
e-mail: ilijakuzman@net.hr
Research topics
Investigation of the causative pathogens, clinical and laboratory parameters, severity of
clinical symptoms and treatment of pneumonia with the development of an algorithm for
diagnosis, assessment of disease severity, hospitalization and antibiotic use. This research is
a continuation of our previous research project.
Novelty in the research of pneumonia is aimed at explaining pathogenic and immunological
mechanisms, occurrence and outcome of disease. Therefore, the focus of our investigation is
the role and the effects of beta-chemokines and matrix metalloproteinases (MMPs) in the
pathogenesis of the disease.
- Beta-chemokines and matrix metalloproteinases most probably participate in complicated
pathogenic and immunologic mechanisms associated with the development and clinical
presentation of pneumonia. Our hypothesis based research aims to determine their roles in
the pathologies associated with organisms that frequently cause community-acquired
pneumonia (Streptococcus pneumoniae, Mycoplasma pneumoniae, Legionella pneumophila)
- In patients with pneumonia we record an elevated level of beta-chemokines (IL-8, MCP-1
and MIP-1β) in systemic circulation
- The level of beta-chemokines and matrix metalloproteinases in systemic circulation has a
very good correlation with the clinical course of disease . The clinical course of disease is
more severe in patients with higher levels of metalloproteinases.
- The values of these immunological indicators can be correlated with routine laboratory
findings, and also with interrelations
Other hypotheses:
- The growing resistance of pneumococcus to beta-lactam antibiotics is not today a barrier for
the treatment of pneumonia with penicillin and other beta-lactam antibiotics
- It is necessary to determine the criteria for severity of disease, hospitalization, when to
switch therapy and the duration of pneumonia treatment
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Ongoing or previous national projects
Pneumonia – diagnostic and treatment guidelines
Teaching and educational involvement
Croatia, Medical School, University of Zagreb
Bosnia and Herzegovina, University of Mostar, High Medical School, Department of
Infectology
Selected publications
1. Kuzman I, Soldo I, Schonwald S, Čulig J. Azithromycin for treatment of community
acquired pneumonia caused by Legionella pneumophila: A retrospective study. Scand J
Infect Dis 1995; 27:503-5.
2. Schonwald S, Kuzman I, Orešković K, Burek V, Škerk V, Car V, Božinović D, Čulig J,
Radošević S. Azithromycin: Single 1.5 dose in the treatment of patients with atypical
pneumonia syndrome – A randomized study. Infection 1999; 27:198-202.
3. Markotić A, Nichol ST, Kuzman I, Sanchez AJ, Ksiazek TG, Gagro A, Rabatić S, Zgorelec
R, Avšič-Županc T, Beus I, Dekaris D. Characteristics of Puumala and Dobrava infections
in Croatia. J Med Virol 2002; 66:542-51.
4. Puljiz I, Kuzman I, Markotić A, Turčinov D, Matić M, Makek N. Electrocardiographic
changes in patients with haemorrhagic fever with renal syndrome. Scand J Infect Dis
2005; 37:594-8.
5. Kuzman I, Puljiz I, Đaković-Rode O. Cure Q fever pneumonia with moxifloxacin: Case
report. Scand J Infect Dis 2005; 37:778-80.
6. Kuzman I, Đaković-Rode O, Oremuš M, Banaszak AM. Clinical efficacy and safety of a
short regimen of azithromycin sequential therapy vs standard cefuroxime sequential
therapy in the treatnment of community-acquired pneumonia: An international,
randomized, open-label study. J Chemother 2005; 17:636-42.
7. Puljiz I, Kuzman I, Đaković-Rode O, Schoenwald N, Miše B. Chlamydia pneumoniae and
Mycoplsma pneumoniae: Comparison of clinical, epidemiological characteristics and
laboratoty profiles. Epidemiol Infect 2006: 134:548-55.
8. Laškaj R, Dodig S, Čepelak I, Kuzman I. Gamma-glutamyltransferase activity and total
antioxidant status in serum and platelets of patients with community-acquired pneumonia.
Arch Med Res 2007; 38:424-31.
9. Kosor Krnić E, Gagro A, Draženović V, Kuzman I, Jeren T, Čečuk-Jeličić E, KerhinBrkljačić V, Gjenero-Margan I, Kaić B, Rakušić S, Sabioncello A, Markotić A, Rabatić S,
Mlinarić-Galinović G, Ddekaris D. Enumeration of haemagglutinin-specific CD8+ T cells
after influenza vaccination using MHC class I peptide tetramers. Scand J Immunol 2007;
67:86-94.
10. Laškaj R, Dodig S, Čepelak I, Kuzman I. Superoxide dismutase, copper and zinc
concentrations in platelet-rich plasma of pneumonia patients. Ann Clin Biochem 2009;
46:123-8.
Other related web-links (personal web-sites, PubMed references, CROSBI or similar)
http://bib.irb.hr/lista-radova?autor=142373&period=2007
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Principal investigator
Assistant Professor Davorka Lukas MD, PhD, DTM&H
Other key personnel
Tomislav Maretić, MD, PhD specialist in infectious diseases
Sanja Kozić, BSc
Professor Biserka Vukić Trošelj, Department for Infectious Diseases, Clinical Hospital
Rijeka
PhD students
Vanja Romih, MD
Teuta Skorin, BSc
Address
HIV/AIDS Center; Center for Tropical and Travel Medicine; University Hospital for
Infectious Diseases, Mirogojska 8, Zagreb, Croatia
tel. ++385 1 2826 222
fax. ++385 1 4678 235
e-mail: davorka.lukas@zg.t-com.hr
Research topics
Tropical and travel medicine, HIV/AIDS, Leishmaniasis (“Leishmaniasis in Balkan
countries” project preparations in progress)
Ongoing or previous national projects
“HIV Infection, Sexual Transmitted Infections and Risky Behavior in Croatian seamen” –
principal investigator
“Epidemiological, clinical and laboratory features of HIV infection in the era of highly active
anitretroviral treatment (HAART) in patients from Croatia” – research team member
Ongoing or previous international projects
EUROSIDA – research team member
Collaboration with international institutions
1. Mahidol – Oxford Tropical Medicine Research Unit, Bangkok, Thailand. Prof Nicholas
White
2. WHO, Dr Jorge Alvar, Leishmania control
3. Institute of Public Health, University of California, San Francisco, USA
Teaching and educational involvement
Infectious Diseases & Tropical Medicine, Medical School, University of Zagreb
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19
International research experience and study visits
1996 London School of Tropical Medicine and Hygiene (Diploma in Tropical Medicine and
Hygiene)
1997 Gambia, MRC Africa (Course: Medicine in Developing Countries)
1999 Karolinska Institute, Department of Immunology, Microbiology, Pathology and
Infectious Diseases, Division of Infectious Diseases, Huddinge University Hospital, Sweden
(Invited speaker – IMPI Seminar)
2004 Training in Clinical Research Center for AIDS Prevention Studies, University of
California, San Francisco, USA (Training in Clinical Research)
2009 Mahidol – Oxford Tropical Medicine Research Unit, Bangkok, Thailand. Prof Nicholas
White (Study visit)
Selected publications
1. Begovac J, Lukas D. Condylomata Lata of Secondary Syphilis. N Engl J Med
2005;352(7):708.
2. Begovac J, Lisić M, Lukas D, Maretić T, Kniewald T, Novotny T. Marked Improvement in
Survival among Adult Croatian AIDS Patients after the Introduction of Highly Active
Antiretroviral Treatment. Coll. Antropol 2006;30(1):175-179.
3. Begovac J, Gedike K, Lukas D, Lepej SZ. Late presentation to care for HIV infection in
Croatia and the effect of interventions during the Croatian Global Fund Project. AIDS Behav.
2008 Jul;12(4 Suppl):S48-53. Epub 2008 May 6.
4. Bozicevic I, Rode OD, Lepej SZ, Johnston LG, Stulhofer A, Dominkovic Z, Bacak V, Lukas
D, Begovac J. Prevalence of Sexually Transmitted Infections Among Men Who Have Sex
with Men in Zagreb, Croatia. AIDS Behav. 2008 Aug 9.
5. Maretić T, Perović M, Vince A, Lukas D, Dekumyoy P, Begovac J. meningitis and
Radiculomyelitis Caused by Angiostrongylus cantonensis. Emerg Infect Dis. 2009 Jun 6.
Other related web-links (personal web-sites, PubMed references, CROSBI or similar)
http://bib.irb.hr/lista-radova?autor=232202&period=2007
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Principal investigator
Associate Professor Alemka Markotić, MD, PhD
Research team
From UHID: Oktavija Rode, MD, MSc; Professor Ilija Kuzman, MD; PhD; Professor Višnja
Škerk, MD, PhD; Ivan Puljiz, MD, PhD
From other Croatian institutions: Professor Josip Margaletić, PhD (Faculty of Forestry,
Zagreb); Professor Nenad Turk, DVM, PhD (Faculty of Veterinary Medicine, Zagreb); Marica
Miletić Medved, MD, PhD (Public Health Institute of Brodsko-posavska County)
PhD students
Lidija Cvetko Krajinović, BSc
Ivan-Christian Kurolt, BSc
Ante Tadin, BSc
Dragan Ledina, MD, MSc (Department of Microbiology, Clinical Hospital Split)
Address
Research Department
University Hospital for Infectious Diseases, Mirogojska 8, 10000 Zagreb, Croatia
Tel: 385-1-2826-148
Mobile phone: 385-91-4012-648
Fax: 385-1-2826-148
e-mail: alemka.markotic@bfm.hr; alemka.markotic@gmail.com
Research topics
Molecular epidemiology of hantaviruses
Apoptosis and hantaviruses
Epidemiology and risk factors for zoonoses transmission (hantaviruses, borrelia, LCMV, TBE,
WNV)
Immunoreactions to hantaviruses and leptospires
Chronic sequelae and hemorrhagic fever with renal syndrome
Immunoreactions, chronic sequelae and zoonoses
Emerging and re-emerging infectious diseases
Clinical immunology and infectious diseases
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21
Ongoing or previous national projects
•
•
•
•
2002-2004 -3-D technology in the production of human native interferon and recombinant
viral proteins; funded by The Croatian Ministry of Science and Technology (P.I. Alemka
Markotić)
2002-2005 – Immunoreactions on intracellular pathogens; funded by The Croatian Ministry
of Science and Technology (P.I. Alemka Markotić)
2006-present – Immunoreactions to hantaviruses and leptospira, funded by The Croatian
Ministry of Science, Education and Sport (P.I. Alemka Markotić)
2007-present – Center for Emerging and Re-emerging infectious Diseases, funded by The
Croatian Ministry of Science and Technology (P.I. Alemka Markotić)
Ongoing or previous international projects
• October 1999-October 2000 – Role of the Cytokines and Chemokines in the Infection of
Human Cells with Hantaviruses, National Research Council (NRC) Award, USA; Molecular
Virology Department, US Army Medical Research for Infectious Diseases (USAMRIID),
Frederick, MD, USA
• 2001- Endemic Zoonoses in Croatia and Slovenia with special accent on hemorrhagic
fever with renal syndrome (P.I's. Full Member of Academy, Professor Dragan Dekaris,
Croatian Academy of Sciences and Arts and Full Member of Academy, Professor Dušan
Ferluga, Slovenian Academy of Sciences and Arts)
• 2003-2004 - Mechanisms of apoptosis in 293HEK cells infected with hantaviruses, funded
by the International Society of Infectious Diseases (ISID)-Small Grants (P.I. Dr. Alemka
Markotić)
• 2004-2009- MetaNET-SEE – Netzwerk akademischer Netzwerke, University Bielefeld,
Germany
• 2007 – present –Telemedicine in Emerging Infectious Diseases; University of Texas
Medical Branch (UTMB), Galveston, TX, USA
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22
Collaboration with international institutions
CENTER FOR EMERGING AND RE-EMERGING INFECTIOUS DISEASES
Emerging infectious disases (EID) are those that have recently appeared in the population,
while re-merging diseases (REID) are those that appear again and then spread in the
population. Many of the causative agents are dangerous pathogens, usually resistant to
existing drugs. Most are microorganisms that could be agents of bioterrorism.
The University Hospital for Infectious Diseases "Dr. Fran Mihaljević" together with national
and international partners from Europe and USA have organized into a virutual collaborative
core-center with the goal of developing a miltidisciplinary approach to EID/REID. The national
partners are the Institute of Immunology Zagreb, the Institute of Public Health Brodskoposavska County, Slavonski Brod, the Faculty of Forestry, the Faculty of Veterinarian
Medicine and the Croatian Academy of Sciences and Arts, Zagreb.
Specific aims of the project are:
(1) Diagnostics –The introduction and development of existing and new diagnostic tools for
EID/REID.
(2) Research – Studies on molecular epidemiology, immunopathogenesis, new therapies
and clinical characteristics of EID/REID.
(3) Education – Development and organization of national and international courses and
conferences on EID/REID topics; training of doctoral studies through existing and new
progams; continuous theoretical and practical education for experts and populations at risk in
various national and international frameworks and programs.
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23
Teaching and educational involvement
• 1992-1994 – Undergraduate study, Medical Microbiology, Department of Microbiology,
Medical School, University of Sarajevo, Bosnia and Herzegovina
• 2001- present -Postgraduate Study - Biomedicine, Medical School, University of Zagreb,
Croatia- courses:
Mechanisms of Allergy
Infection of Biomaterials
Pathogenesis of infectious diseases
• 2008- present –Undergraduate study in English – Infectious Diseases, Medical School,
University of Zagreb, Croatia
• 2002 – present -Postgraduate Study Biomedicine and Health, Medical School, University of
Osijek, Croatia – courses:
Pathogenesis of Viral and Bacterial Infections
Antimicrobial Therapy
• 2002 – present -Undergraduate study, School for Food and Technology, University of
Zagreb, Croatia, Lectures in Immunology
• 2003- present -Postgraduate study, Biomedicine, Medical School, University of Rijeka,
Croatia; Infections caused by hantaviruses
• 2010 – Postgraduate study, Biomedicine, Medical School, University of Mostar, Bosnia and
Herzegovina; Emerging and re-emerging Infectious Diseases
• 2010 – Undergraduate study, University Center for Forensic Sciences, Split, Croatia;
Bioterrorism and Biodefense
International research experience and study visits
October 1999 - October 2000 - National Research Council (NRC), Washington, USA,
Research Associatship Programs - Molecular Virology Department, US Army Medical
Research for Infectious Diseases (USAMRIID), Frederick, MD, USA
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24
Selected publications
1. Markotić A, Šarčević A, Hlača D, Barač V, LeDuc JW. Rats and hantavirus disease. Nature
Med 1995; 1(10):977.
2. Markotić A, LeDuc JW, Hlača D, Rabatić S, Šarčević A, Dašić G, Gagro A, Kuzman I,
Barač V, Avšič-Županc T, Beus I, Dekaris D. Hantaviruses are a likely threat to NATO
forces in Bosnia and Herzegovina and Croatia. Nature Med 1996; 2(3):269-270.
3. Markotić A, Dašić G, Gagro A, Sabioncello A, Rabatić S, Kuzman I, Zgorelec R, Smoljan I,
Beus I, Avšič Županc T, Dekaris D. Role of the blood mononuclear cell phenotype changes
in the pathogenesis of hemorrhagic fever with renal syndrome. Clin Exp Immunol 1999;
115:329-334.
4. Markotić A, Nichol ST, Kuzman I, Sanchez AJ, Ksiazek TG, Gagro A, Rabatić S, Zgorelec
R, Avšič Županc T, Beus I, Dekaris D. Characteristics of Puumala and Dobrava Infections
in Croatia. J Med Virol 2002; 66:542-551.
5. Markotić A, Kuzman I, Babić K, Gagro A, Nichol S, Ksiazek TG, Rabatić S, Dekaris D.
Double trouble: hemorrhagic fever with renal syndrome and leptospirosis. Scand J Infect
Dis 2002;34:221-224.
6. Markotić A. The Balkan syndrome. Lancet 2002; 359: 166.
7. Miletić Medved M, Markotić A, Cebalo Lj, Turković B, Avšič Županc T. Haemorrhagic feer
with renal syndrome in Croatia. Lancet 2002; 360: 415-416.
8. Markotić A, Hensley L, Geisbert T, Spik K, Schmaljohn C. Hantaviruses induce
cytopathic effect and apoptosis in continuous human embryonic kidney cells. J Gen Virol
2003; 84: 2197-2202.
9. Cvetko L, Markotić A, Plyusnina A, Margaletic J, Miletic-Medved M, Turk N, Milas Z,
Avsic-Zupanc T, Plyusnin A. Puumala virus in Croatia in the 2002 HFRS outbreak. J
Med Virol. 2005 Oct;77(2):290-4.
10. Cvetko L, Turk N, Markotic A, Milas Z, Margaletic J, Miletic-Medved M, Plyusnin A,
Baranton G, Postic D, Avsic-Zupanc T. Short report: dual infections with Puumala virus
and Leptospira interrogans serovar lora in a bank vole (Clethrionomys glareolus). Am J
Trop Med Hyg. 2006 Apr;74(4):612-4.
11. Cebalo Lj, Markotić A. "Chemokine Production Predominates in Human Monocytes
Infected with Tula Virus" Viral Immunology. 2007;20(1). 206-13.
12. Markotić A, Hensley L, Daddario K, Spik K, Anderson K, Schmaljohn C. Pathogenic
hantaviruses elicit different immunoreactions in THP-1 cells and primary monocytes and
induce differentiation of human monocytes to dendritic-like cells. Coll Antropol.
2007;31:1159-67.
13. Markotić A, Skerk V, Cvetko Krajinović L, Beus A. Is the clinical picture of Schnitzler
syndrome always Schnitzler syndrome? Clin Exp Rheumatol. 2009;27(3):507-9.
Other related web-links (personal web-sites, PubMed references, CROSBI or similar)
http://bib.irb.hr/lista-radova?autor=213111&period=2007
http://bib.irb.hr/lista-radova?sif_proj=143-1430115-0103&period=2007
http://www.nzz.hr/index.php?option=com_content&task=view&id=12&Itemid=53
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25
Principal investigator
Professor Višnja Škerk, MD, PhD
Research team
Associate Professor Alemka Markotić, MD, PhD
Professor Ognjen Kraus, MD, PhD and Goran Štimac, MD, PhD, Urology Department,
University Hospital “Sestre milosrdnice”, Zagreb
Professor Ranka Štern Padovan, MD, PhD, University Hospital “Rebro”, Zagreb
PhD students
Miram Pasini, MD – enrolled in doctoral studies
Martina Vargović, MD - enrolled in doctoral studies
Antea Topić, MD, MSc – “Detection of M.genitalium in males with chronic prostatitis
syndrome: prevalence, development of diagnostic criteria and determining the needs for
routine screening of the population“ (Doctoral dissertation in process)
Srđan Roglić, MD - “Comparison of clinical symptoms scored according to the National
Institutes of Health chronic prostatitis symptoms index and assessment of antimicrobial
treatment in patients with chronic prostatitis syndrome” (Master’ thesis in process)
Saša Andrašević, MD, MSc
Address
Department for Urogenital Tract Infections University Hospital for Infectious Diseases “Dr.
Fran Mihaljevic”, Mirogojska 8, 10 000 Zagreb, Croatia,
phone: ++385 1 2826 237; fax: ++385 1 2826 471, e-mail: vskerk@bfm.hr
Research topics
Urogenital infections, sexually transmitted diseases, prostatitis syndrome, chlamydial
infections, antmicrobial therapy
Ongoing or previous national projects (titles)
Principal Investigator in the following research projects of the Croatian Ministry of Science,
Education and Sports:
Past
Clinical and laboratory parameters of bacteremia and sepsis (301-488)
Urogenital infections caused by Chlamydia trahomatis (143-004)
Clinical significance of Ureaplasma urealyticum and Mycoplasma hominis (143-003)
Ongoing
Diagnostics and treatment of patients with prostatitis syndrome (143-1080002-0050)
Collaboration with international institutions
Research on prostatitis syndrome – collaboration with
Gianpaolo Perletti, Laboratory of Toxicology and Pharmacology, Università degli Studi
dell’Insubria, Busto A./Varese, Italia
Vittorio Magri, Urology and Urological Sonography Clinic, Azienda Ospedaliera Istituti Clinici
di Perfezionamento, Milano, Italia
Kurt G Naber, International Society of Chemotherapy
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26
Teaching and educational involvement
University of Zagreb Faculty of Dental Medicine - Infectious Disease Program
University of Zagreb Faculty of Medicine - Infectious Disease Program
Selected publications
1. Škerk V, Schönwald S, Strapač Z, Beus A, Francetić I, Krhen I, et al. Duration of clinical
symptoms in female patients with acute urethral syndrome caused by chlamydia
trachomatis treated with azithromycin or doxycycline. J Chemoth 2001 ;13(2):176-81.
2. Škerk V, Schönwald S, Krhen I, Markovinović L, Baršic B, Mareković I, et al. Comparative
analysis of azithromycin and clarithromycin efficacy and tolerability in the treatment of
chronic prostatitis caused by chlamydia trachomatis. J Chemoth 2002 ;14(4):384-9.
3. Škerk V, Schönwald S, Krhen I, Markovinovi L, Beus A, Kuzmanovi N-, et al. Aetiology of
chronic prostatitis. Int J Antimicrob Agents. 2002 ;19(6):471-4.
4. Škerk V, Schönwald S, Granić J, Krhen I, Baršić B, Mareković I, et al. Chronic prostatitis
caused by trichomonas vaginalis - diagnosis and treatment. J Chemoth 2002 ;14(5):537-8.
5. Škerk V, Schönwald S, Krhen I, Banaszak A, Begovac J, Strugar J, et al. Comparative
analysis of azithromycin and ciprofloxacin in the treatment of chronic prostatitis caused by
chlamydia trachomatis. Int J Antimicrob Agents. 2003 ;21(5):457-62.
6. Škerk V, Čajić V, Markovinović L, Roglić S, Zekan Š, Škerk V, et al. Etiology of chronic
prostatitis syndrome in patients treated at the university hospital for infectious diseases
»Dr. Fran Mihaljević « from 2003 to 2005. Coll Antropol. 2006 ;30(Suppl 2):145-9.
7. Škerk V, Krhen I, Lisić M, Begovac J, Roglić S, Škerk V, et al. Comparative randomized
pilot study of azithromycin and doxycycline efficacy in the treatment of prostate infection
caused by chlamydia trachomatis. Int J Antimicrob Agents. 2004 ;24(2):188-91.
8. Škerk V, Krhen I, Schonwald S, Cajic V, Markovinovic L, Roglic S, et al. The role of
unusual pathogens in prostatitis syndrome. Int J Antimicrob Agents. 2004 ;24(Suppl
1):S53-6.
9. Škerk V, Markovinović L, Zekan Š, Jakšić J, Lepej SZ, Markotić A, et al. The significance
of chlamydia trachomatis in urethritis and prostatitis - differences in therapeutic approach croatian experience. J Chemoth 2009 ;21(1):63-7.
10. Škerk V, Roglić S, Cajić V, Markotić A, Radonić A, Škerk V, et al. Comparison of clinical
symptoms scored according to the national institutes of health chronic prostatitis
symptoms index and assessment of antimicrobial treatment in patients with chronic
prostatitis syndrome. J Chemoth 2009 ;21(2):181-7.
Other related web-links (personal web-sites, PubMed references, CROSBI or similar)
http://bib.irb.hr/lista-radova?autor=171634&period=2007
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Principal Investigator (Group Leader)
Associate Professor Arjana Tambic Andrasevic, MD, PhD
Research team
Assist. Prof. Suzana Bukovski, MD, PhD
Višnja Kovačević, MD, MSc
Iva Butić, MD
Silvija Šoprek, MD
Irina Cazin, MD
PhD students
Marija Gužvinec, BSc
Marko Jelić, BSc
Address
Department of Clinical Microbiology, University Hospital for Infectious Diseases
Mirogojska 8, 10000 Zagreb, Croatia, tel. ++385 1 2826 282; fax ++385 1 2826 280
e-mail: arjana.tambic@bfm.hr
Research topics
Bacterial resistance to antibiotics
Rational antibiotic prescribing
Hospital care associated infections
Ongoing or previous national projects
1991 – 1995: Croatian Ministry of Health and Technology project "The significance of
P-fimbriae detection in choosing therapy for urinary tract infection" (project No. 3-01199 ).
1998 – 2006: Croatian Ministry of Health and Technology project “Principles of
antimicrobial agents use” (project No. 108 195).
2007 on: Croatian Ministry of Health and Social Welfare project “Detection and
characterization of causative agents in bacterial meningitis and pneumonia” (project
No. 143-1080002-0101).
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Ongoing or previous international projects
1996 – 1999 The British Council Academic Links and Interchange Scheme – ALIS
project “Comparison of epidemiologically unrelated strains of Staphylococcus aureus
that express similar phenotypic characteristics – testing new methods in
epidemiological typing”.
2001 - 2004 The British Council Academic Links and Interchange Scheme – ALIS
project “Antiobiotic resistance surveillance and detection of resistance mechanisms in
bacteria causing human infections”.
2006 - 2008 The MATRA project „Antibiotic resistance surveillance in human medicine“
2001 – 2009 The European Antibiotic Resistance Surveillance System (EARSS)
2001 – 2010 The European Surveillance of Antibiotic Consumption (ESAC)
Collaboration with international institutions
United Medical and Dental Schools of Guy’s and St. Thomas’s Hospitals, London, UK
two ALIS projects on staphylococcal typing and antibiotic resistance; leaders of the project: A.
Tambic Andrasevic from the Croatian side and G.L. French from the British side
National Medicines Institute, Warsaw, Poland
Research topics: typing of bacterial pathogens; detection of antibiotic resistance mechanisms
Contact persons from the Croatian side: A. Tambic Andrasevic, S. Bukovski, M. Guzvinec
Contact persons from the Polish side: W. Hryniewicz, M. Gniadkowski, R. Izdebski, J. Fiett
Teaching and educational involvement
Medical School, Zagreb
Medical School, Osijek
International research experience and study visits
A. Tambic Andrasevic:
January 9 – August 8, 1995 "honorary registrar" at Guy's and St. Thomas's Hospital
NHS Trust and "lecturer" at the Microbiology department of the United Medical and
Dental Schools (UMDS) of Guy's and St. Thomas's Hospitals, London
October 14 – November 24, 1996, UMDS Guy's and St. Thomas's
November 2 – 16, 1997, Great Ormond Street Hospital for Children
August 28 – September 21, 1998, UMDS Guy's and St. Thomas's
May 8 – 13, 2006, study visit to the Netherlands
June 24 – July 8, 2006, Universitats Klinik Freiburg, Freiburg iBr, Germany
M. Guzvinec:
May 26-28, 2006: 36 th ESCMID Postgraduate Course on “Detection and
characterization of metallo-beta-lactamases”, Verona, Italy
April 29 – May 4, 2007: 40th ESCMID Postgraduate Education Course on Bacterial
Molecular Typing, Oeiras, Portugal
June 15–21, 2008: 7th Workshop “Prof. V. J. Benedi”: Mechanisms of Antimicrobial
Resistance. A practical Approach. (ESCMID Postgraduate Education Course), Palma
de Mallorca, Spain
September 28 – December 11, 2009: short-term FEMS research visit to the
Department of Molecular Microbiology, National Medicines Institute in Warsaw, Poland
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Selected publications
1. Tambić A, Power EGM, Tambić T, Snur I, French GL. Epidemiological Analysis of
methicillin-resistant Staphylococcus aureus in a Zagreb Trauma Hospital using a
randomly amplified polymorphic DNA-typing method. Eur J Clin Microbiol Infect Dis
1999; 18: 335-40.
2. Pankuch GA, Bozdogan B, Nagai K, Tambić Andrašević A, Schoenwald S, Tambić T,
Kalenić S, Pleško S, Tepeš N, Kotarski Z, Payerl Pal M, Appelbaum PC. Incidence,
epidemiology and characteristics of quinolone-nonsusceptible S. pneumoniae in
Croatia. Antimicrob Agents Chemother 2002; 46: 2671-5
3. Tambić Andrašević A, Tambić T, Kalenić S, Janković V. Surveillance for antibiotic
resistance in Croatia. Emerg Infect Dis 2002;8:14-18.
4. Nagai K, Appelbaum PC, Davies TA, Kelly LM, Hoellman DB, Tambic Andrasevic A,
Drukalska L, Hryniewicz W, Jacobs MR, Kolman J, Miciuleviciene J, Pana M,
Setchanova L, Thege MK, Hupkova H, Trupl J, Urbaskova P. Susceptibilities to
telithromycin and six other agents and the prevalence of macrolide resistance due to L4
ribosomal protein mutation among 992 Pneumococci from 10 Central and Eastern
European Countries. Antimicrob Agents Chemother 2002; 46: 371-7.
5. Malbruny B, Nagai K, Coquemont M, Bozdogan B, Tambic Andrašević A, Hupkova H,
Leclercq R, Appelbaum PC. Resistance to macrolides in clinical isolates of
Streptococcus pyogenes due to ribosomal mutations. J Antimicrob Ther (JAC),
2002;49:935-9.
6. Barsic B, Tambic A, Santini M, Klinar I, Kutlesa M, Krajinovic V. Antibiotic resistance
among nosocomial isolates in a Croatian intensive care unit – results of a twelve-year
focal surveillance of nosocomial infections. J Chemother 2004;16:273-281.
7. Giakkoupi P, Tambic-Andrasevic A, Vourli S, Skrlin J, Sestan-Crnek S, Tzouvelekis
LS, Vatopoulos AC. Transferable DHA-1 cephalosporinase in Escherichia coli. Int J
Antimicrob Agents 2006;27(1):77-80. Epub 2005 Dec 13.
8. Larissa Grigoryan, Flora M. Haaijer-Ruskamp, Johannes G.M. Burgerhof, Reli
Mechtler, Reginald Deschepper, Arjana Tambic-Andrasevic, et al. Self-medication with
Antimicrobial Drugs in Europe. Emerg Inf Dis 2006;12:452-9.
9. Krzysztori-Russjan J, Tambic Andrasevic A, Bukovski S, Sabat A, Hryniewicz W. First
community-acquired methicillin-resistant Staphylococcus aureus (MRSA) strains in
Croatia. Clin Micro Inf Dis (CMI) 2006; 12: 695-699.
10. Gužvinec M, Tešović G, Tambić-Andrašević A, Židovec-Lepej S, Trošelj Vukić B,
Begovac J. The epidemiology of invasive Streptococcus pneumoniae disease in
Croatian children. Med Sci Monit, 2008; 14: PH59-64
Other related web-links (personal web-sites, PubMed references, CROSBI or similar)
http://bib.irb.hr/lista-radova?autor=172380&period=2007
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Principal investigator
Assistant Professor Goran Tešović, MD, PhD
Research team
Department for Pediatric Infectious Diseases: Branko MIše, Srđan Roglić , Tihana Kniewald
Collaborators from other Departments at the University Hospital for Infectious Diseases:
Snježana Židovec Lepej, Arjana Tambić Andrašević, Marija Gužvinec, Božica Sokolić
PhD or Postdoctoral Students
Anamarija Čavčić, MD
Address
Department for Pediatric Infectious Diseases, University Hospital for Infectious Diseases “Dr.
Fran Mihaljevic”, Mirogojska 8, 10 000 Zagreb, Croatia
phone: ++ 385 1 2826 156; fax: ++ 385 1 2826 158, e-mail: gtesovic@bfm.hr
Research topics
• The role of cytokines in the pathogenesis of viral CNS infections in children.
Seroepidemiology of invasive pneumococcal disease.
• New methods in establishing the true incidence of invasive pneumococcal diseases in
childhood
• Connatal CMV infection – neurodevelopmental outcome
Ongoing or previous national projects
Project title: New methods in diagnostics of acute non-bacterial CNS inflammations in
children (funded by the Croatian Ministry of Science, Education and Sports, project code 1080000000-3485), project period 2008-2011
Role in the project: Principal Investigator
Project title: Neurodevelopmental outcome in children with intrauterine growth retardation
and/or hypoxia , funded by the Croatian Ministry of Science, Education and Sports, project
code 072-1081870-0025, project period 2007-2009, principal investigator Vlatka Mejaški
Bošnjak
Role in the project: Investigator
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Teaching and educational involvement (list the programs or Universities)
University of Zagreb School of Medicine, Zagreb
Study of Medicine, Infectious Diseases
Post-graduate studies in infectious diseases, epidemiology and pediatrics (pediatric
infectious diseases)
Post-graduate PhD studies (pathogenesis of CNS infections)
Selected publications
1. Kutlesa M, Tesović G, Knezović I, Mise B, Visković K, Barisić N. Ischemic stroke
associated with adenoviral infection in a 4-year old boy. Wien Klin Wochenschr.
2009;121(23-24):776-9.
2. Guzvinec M, Tesović G, Tambić-Andrasević A, Zidovec-Lepej S, Vukić BT, Begovac J.
The epidemiology of invasive Streptococcus pneumoniae infections in Croatian
children.Med Sci Monit. 2008 Dec;14(12):PH59-64.
3. Tesović G, Poljak M, Lunar MM, Kocjan BJ, Seme K, Vukić BT, Sternak SL, Cajić V,
Vince A. Horizontal transmission of the Leningrad-Zagreb mumps strain: A report of
three cases. Vaccine. 2008;26(16):1922-5.
4. Lepej SZ, Tesovic G, Sternak SL, Jeren T. Naive and memory CD4+ T-cells in the
cerebrospinal fluid of children with aseptic meningitis following measles-mumps-rubella
vaccination and enteroviral meningitis. Immunol Invest. 2007;36(3):321-35.
5. Tesović G, Lesnikar V. Aseptic meningitis after vaccination with L-Zagreb mumps
strain--virologically confirmed cases. Vaccine. 2006 Sep 29;24(40-41):6371-3.
6. Santak M, Kosutić-Gulija T, Tesović G, Ljubin-Sternak S, Gjenero-Margan I, BeticaRadić L, Forcić D. Mumps virus strains isolated in Croatia in 1998 and 2005:
Genotyping and putative antigenic relatedness to vaccine strains. J Med Virol.
2006;78(5):638-43.
7. Forcic D, Ivancic J, Baricevic M, Mahovlic V, Tesovic G, Bozinovic D, Gjenero Margan
I, Mazuran R. Genetic characterization of wild type measles virus isolated in Croatia
during the 2003-2004 outbreak. J Med Virol. 2005;75(2):307-12.
8. Forčić D, Baricević M, Zgorelec R, Kruzić V, Kaić B, Marina BM, Sojat LC, Tesović G,
Mazuran R. Detection and characterization of measles virus strains in cases of
subacute sclerosing panencephalitis in Croatia. Virus Res. 2004;99(1):51-6.
9. Vukelic D, Bozinovic D, Morovic M, Tesovic G, Ruzic Sabljic E, Barisic N, Knezovic I.
Opsoclonus-myoclonus syndrome in a child with neuroborreliosis. J Infect. 2000
Mar;40(2):189-91.
10. Tesović G, Begovac J, Baće A. Tesović G, Begovac J, Baće A. Aseptic meningitis after
measles, mumps, and rubella vaccine. Lancet. 1993 Jun 12;341(8859):1541.
Other related web-links (personal web-sites, PubMed references, CROSBI or similar)
CROSBI: http://bib.irb.hr/lista-radova?sif_proj=108-0000000-3485&print=true
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Principal investigator
Professor Adriana Vince, MD, PhD
Research team
Department of Viral Hepatitis:
Ivan Kurelac, MD, PhD
Vjeran Čajić, MD
Collaborators from other Departments at the University Hospital for Infectious Diseases:
Snježana Židovec Lepej, Sanja Kozic, Bruno Baršić, Josip Begovac, Tomislav Maretić
PhD students
Davorka Dušek, MD
Jelena Budimir, MD
Neven Papić, MD
Address
University Hospital for Infectious Diseases “Dr. Fran Mihaljevic”, Mirogojska 8, 10 000 Zagreb,
Croatia, tel. ++ 385 1 2826 403; fax: ++ 385 1 2826 131, e-mail: avince@bfm.hr
Croatian Reference Center for Viral Hepatitis at the University Hospital for Infectious
Diseases, Zagreb consists of:
Outpatient Clinics for Viral Hepatitis (3800 patient visits per year)
Department of Viral Hepatitis (50 hospitalised patients with hepatitis B and 250 patients with
hepatitis C per year)
Laboratory for serological diagnostics of viral hepatitis
Department of cellular immunity and molecular diagnostics
External collaborators of the Reference center:
Liver transplantation unit, Clinical Hospital Merkur, Zagreb
National centers for IVDU treatment and care
Department of molecular genetics, Faculty of Natural Sciences and Mathematics, University
of Zagreb
NGO HEPATOS, NGO ABC Hepatitis
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Research topics
• Seroepidemiology and molecular epidemiology of viral hepatitis
• Immunopathogenesis of hepatitis B and C
• Clinical research with emphasis on treatment of hepatitis C
• Infections in immunocommpromised hosts (transplant patients, hemato-oncology
patients), human papillomaviruses, molecular diagnostics of viral infections
Ongoing or previous national projects
Project title: Immunopathogenesis of hepatitis B and C, funded by the Croatian Ministry of
Science, Education and Sports, project code 143-0000000-0117, project period 2007-2009
Role in the project for A. Vince: Principal Investigator
Project title: Leukemia and stem cell transplantation, funded by the Croatian Ministry of
Science, Education and Sports, project code 108-1081872-1913, project period 2007-2009,
principal investigator: B. Labar
Role in the project for A. Vince: Investigator
Project title: Molecular diagnostics of EBV and CMV infections, funded by the Croatian
Ministry of Science, Education and Sports, project code 0143001, project period 2002-2006
Role in the project for A. Vince: Principal Investigator
Ongoing or previous international projects
1. Project title: WHO GRASP Prediction of clinical rules in diagnosis of streptoccocal
pharyngits in children, project duration 2001-2003,
Role in the project for A. Vince: National Coordinator
2. Project title: Optimization of methods for HCV RNA isolation from the blood, bilateral
projects between Croatia and Austria, funded by the Croatian Ministry of Science, Education
and Sports and Austrian Ministry of Science, project duration 2002-2006
principal investigator for Slovenia: H. Kessler
principal investigator for Croatia: A. Vince
Collaboration with international institutions
Collaborations with other international institutions:
1. Department of Gastroenterology and Hepatology, Medical Faculty Hannover, Prof. Heiner
Wedemeyer
2. Laboratory for Molecular Virology and Slovenian Reference center for AIDS, Medical
Faculty, University of Ljubljana, Slovenia, Prof. Mario Poljak
3. Institute of Hygiene, Karl Franz Medical School, Graz, Austria, Prof. Harald Kessler
4. Department of Epidemiology, UCLA School of Public Health, Los Angeles, Anne W.
Rimoin, Ph.D., M.P.H, Director, UCLA DRC Research Program
5. EASL member (European Association for Study of Liver)
6. UEMS ID secretary/treasurer (European Assoc.of Medical Specialties-ID section)
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Teaching and educational involvement
University of Zagreb School of Medicine, Zagreb, Croatia
Graduate and post-graduate studies in infectious diseases (infectious diseases diagnostics,
viral hepatitis, cytology,) and Medical studies in English
Faculty of Veterinary Medicine, University of Zagreb
University of Ljubljana, Slovenia; University of Sarajevo, Bosnia
International research experience and study visits
1996-Dartmouth Medical School, NH
1997 Roche Diagnostics Centre, Branchburg
1998, 2001, 2003, 2004 - Graz, Austria, Karl-Franz University
2007-CDC , Atlanta
Selected publications
1. Seme K, Lepej SZ, Lunar MM, Iscic-Bes J, Planinic A, Kocjan BJ, Vince A, Poljak M.
Digene HPV Genotyping RH Test RUO: comparative evaluation with INNO-LiPA HPV
Genotyping Extra test for detection of 18 high risk and probable high risk human
papillomavirus genotypes. J Clin Virol 2009;46:176-9.
2. Cavlek TV, Margan IG, Lepej SZ, Kolaric B, Vince A. Seroprevalence, risk factors and
hepatitis C virus genotypes in groups with high-risk sexual behavior in Croatia. J Med Virol
2009;81:1348-53.
3. Poljak M, Kocjan BJ, Kovanda A, Lunar MM, Židovec Lepej S, Planinic A, Seme K, Vince
A. Human papillomavirus genotype specificity of hybrid capture 2 low-risk probe coctail. J Clin
Microbiol 2009;47:2611-5
4. Deterding K, Constantinescu I, Nedelcu FD, Gervain J, Nemecek V, Srtunecky O, Vince A,
et al. Prevalence of HBV genotypes in Central and Eastern Europe. J Med Virol 2008;80:
1707-11.
5. Rimoin AW, Walker CL, Chitale RA, Hamza HS, Vince A, et al. Variation in clinical
presentation of childhood group A streptococcal pharyngitis in four countries. J Trop Pediatr
2008;54:308-312.
6. Tešović G, Poljak M, Lunar MM, Kocjan BJ, Seme K, Vukić BT, Sternak SL, Čajić V, Vince
A. Horizontal transmission o the Leningrad-Zagreb mumps vaccine strain. A report of three
cases. Vaccine 2008; 26:1922-5.
7. Vince A, Lepej SZ, Kurelac I, Barsic B, Kozic S, Klinar I, Zarkovic K. Virological and
immunological characteristics of fatal Epstein-Barr mononucleosis in a 17-year-old Caucasian
male presenting with meningoencephalitis and hemophagocytic syndrome. J Neurovirol
2007;13:389-396.
8. Židovec Lepej S, Grgić I, Poljak M, Iščić-Beš J, Škerk V, Vince D, Dušek D, Vince A.
Detection of human papillomavirus genotypes 16/18/45 by hybrid capture hybridisation
genotyping probe in clinical specimens: the first report. J Clin Virol 2007;40:171-172.
9. Lepej Židovec S, Mišić.Majerus L, Jeren T, Rode OD, Remenar A, Šporec V, Vince A.
Chemokines CXCL10 and CXCL11 in the cerebrospinal fluid of patients with tick-borne
encephalitis. Acta Neurol Scand 2007;115:109-114.
10. Vince A, Iščić-Beš J, Židovec Lepej S, Baća-Vrakela I, Bradarić N, Kurelac I, Vince DB.
Distribution of hepatitis C virus genotypes in Croatia: a 10 year retrospective study of four
geographic regions. Coll Antropol 2006; 30: 139-143.
Other related web-links (personal web-sites, PubMed references, CROSBI or similar)
http://bib.irb.hr/lista-radova?sif_proj=143-0000000-0117&period=2007
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Principal investigator
Snježana Židovec Lepej, PhD, Senior Scientific Associate
Research team
Department of Cellular Immunology and Molecular Diagnostics staff: Ivana Baca Vrakela,
BSc; Ivana Grgic, BSc; Janja Iscic Bes, BSc; Natasa Kutela, BSc; Jasna Matanovic
Collaborators from other Departments at the University Hospital for Infectious Diseases: Josip
Begovac, Adriana Vince, Goran Tešović, Bruno Baršić, Oktavija Đaković Rode
PhD students
Ana Planinić, BSc
Lana Gorenec, BSc
Address
Department of Cellular Immunology and Molecular Diagnostics, University Hospital for
Infectious Diseases “Dr. Fran Mihaljevic”, Mirogojska 8, 10 000 Zagreb, Croatia
tel: ++ 385 1 2826 270; fax: ++ 385 1 2826 131, e-mail: snjezana.zidovec.lepej@bfm.hr
Research topics
Immunology of infectious diseases, cytokines, antigen-specific immunity, HIV, molecular
virology, molecular diagnostics
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Ongoing or previous national projects
Project title: Immune reconstitution and resistance to antiretroviral drugs in HIV-infected
persons from Croatia (funded by the Croatian Ministry of Science, Education and Sports,
project code 143-1080116-0097), project period 2007-2012
Role in the project for S. Zidovec Lepej: principal investigator
Project title: Immunopathogenesis of hepatitis B and C, funded by the Croatian Ministry of
Science, Education and Sports, project code 143-0000000-0117, project period 2007-2009,
principal investigator Adriana Vince
Role in the project for S. Zidovec Lepej: investigator
Project title: Cellular immunity in tick-borne encephalitis, funded by the Croatian Ministry of
Science, Education and Sports, project code 0143999, project period 2003-2006, principal
investigator Tatjana Jeren
Role in the project for S. Zidovec Lepej: investigator
Project title: Characteristics of HIV-infection in Croatia at the time of HAART, funded by the
Croatian Ministry of Science, Education and Sports, project code 108026, project period
2001-2006, principal investigator Josip Begovac
Role in the project for S. Zidovec Lepej: investigator
Project title: Mechanisms of immune reactions and immunomodulation, funded by the
Croatian Ministry of Science, Education and Sports, project code 3-01-127, project period
1993-1995, principal investigators Dragan Dekaris and Vlatko Silobrčić
Role in the project for S. Zidovec Lepej: investigator
Ongoing or previous international projects
1. Project title: EuropeHIVResistance (http://www.europehivresistance.org), funded by the
European Union, 6th framework, pribcipal investigators Charles Boucher and Annemarie
Wensing, project duration 2003-2009, extention 2010-01-21
Role in the project for S. Zidovec Lepej: National Coordinator
2. Project title: Molecular epidemiology of HIV and resistance to antiretroviral drugs, bilateral
projects between Croatia and Slovenia, funded by the Croatian Ministry of Science, Education
and Sports and Slovenian Ministry of Science, project duration 2009-2011
principal investigator for Slovenia: Mario Poljak
principal investigator for Croatia: S. Zidovec Lepej
Collaborations with international institutions
1. Collaborator Ivana Bozicevic, WHO Collaborative Center for Capacity building in HIV
Surveillance, Andrija Stampar School of Public Health, Medical School, University of
Zagreb, Croatia, http://www.surveillancezagreb.org
- educational activities focusing on immunological and virological aspects of HIV infection
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Teaching and educational involvement
1. Faculty of Natural Science and Mathematics, University of Zagreb, Croatia
- Graduate studies in molecular biology (molecular techniques in diagnostics)
- Post-graduate studies in biomedicine (immunology, cytokines, antiviral immunity)
2. University of Zagreb School of Medicine, Zagreb, Croatia
Post-graduate studies in infectious diseases (infectious diseases diagnostics, viral hepatitis,
cytology)
Selected publications
1. Seme K, Lepej SZ, Lunar MM, Iscic-Bes J, Planinic A, Kocjan BJ, Vince A, Poljak M.
Digene HPV Genotyping RH Test RUO: comparative evaluation with INNO-LiPA HPV
Genotyping Extra test for detection of 18 high risk and probable high risk human
papillomavirus genotypes. J Clin Virol 2009;46:176-9.
2. Cavlek TV, Margan IG, Lepej SZ, Kolaric B, Vince A. Seroprevalence, risk factors and
hepatitis C virus genotypes in groups with high-risk sexual behavior in Croatia. J Med Virol
2009;81:1348-53.
3. Poljak M, Kocjan BJ, Kovanda A, Lunar MM, Židovec Lepej S, Planinic A, Seme K, Vince
A. Human papillomavirus genotype specificity of hybrid capture 2 low-risk probe coctail. J Clin
Microbiol 2009;47:2611-5
4. Božičević I, Đaković Rode O, Židovec Lepej S, Johnston LG, Stulhofer, A, Dominiković Z,
Bačak V, Lukas D, Begovac D. Prevalence of sexually-transmitted infections and sexual risk
behaviours aomong men who have sex with men in Zagreb, Croatia. AIDS Behav
2009;13:303-9
5. Begovac J, Gedike K, Lukas D, Židovec Lepej S. Late presentation to care for HIV infection
in Croatia and the effect of interventions during the Croatian Global Fund Project. AIDS
Behav 2008:12(suppl 4): S48-S53.
6. Lepej Židovec S, Mišić.Majerus L, Jeren T, Rode OD, Remenar A, Šporec V, Vince A.
Chemokines CXCL10 and CXCL11 in the cerebrospinal fluid of patients with tick-borne
encephalitis. Acta Neurol Scand 2007;115:109-114.
7. Židovec Lepej S, Grgić I, Poljak M, Iščić-Beš J, Škerk V, Vince D, Dušek D, Vince A.
Detection of human papillomavirus genotypes 16/18/45 by hybrid capture hybridisation
genotyping probe in clinical specimens: the first report. J Clin Virol 2007;40:171-172.
8. Đikić D, Židovec Lepej S, Remenar A, Horvat-Knežević A, Benković V, Lisičić D, Sajli L,
Springer O. The effects of prometryne on subchronically treated mice evaluated by single cell
gel electroforesis (COMET) assay. Environmental Toxicology and Pharmacology. 2008;60:3543.
9. Lepej Židovec S, Mišić-Majerus L, Jeren T, Rode OD, Remenar A, Šporec V, Vince A.
Chemokines CXCL10 and CXCL11 in the cerebrospinal fluid of patients with tick-borne
encephalitis. Acta Neurol Scand 2007;115:109-114
10. Židovec Lepej S, Grgić I, Poljak M, Iščić-Beš J, Škerk V, Vince DB, Dušek D, Vince A.
Detection of human papillomavirus genotypes 16/18/45 by hybrid capture hybridisation
genotyping probe in clinical specimens: the first report. J Clin Virol 2007;40:171-2.
Other related web-links (personal web-sites, PubMed references, CROSBI or similar)
CROSBI: http://bib.irb.hr/lista-radova?sif_proj=143-1080116-0097&period=2007
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