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BIOSTATISTICS GRADUATE PROGRAM
Graduate Student Biosketches
Laurel Bastone
Admitted: 2001
Education:
MS (Biostatistics), Columbia University, 2001
BA (Comparative Literature), Yale University, 1999
Research Interests:
Statistical genetics.
Publications:
Bastone L., Reilly M., Rader DJ, Foulkes AS. MDR and PRP: A comparison of methods for high-order
genotype-phenotype associations. Hum Hered. 2004; 58(2):82-92.
Contact: lbastone@cceb.upenn.edu
Bing Cai
Admitted: 2004
Education:
MS (Biostatistics), McGill University, 1999
MS (Virology), Wuhan University, China, 1989
BS (Biochemistry), Wuhan University, China, 1986
Research Interests:
Statistical genetics and pharmacogenetics, pharmacoepidemiology, statistical computing and data mining,
longitudinal data analysis; clinical trials.
Publications:
Cai B., Zhu JH, Hu QL, Esposito J, Hou YD: Expression of rabies virus glycoprotein with vaccinia virus Tiantan
Strain. Chinese Journal of Microbiology and Immunology. (1993) Vol. 12(2): 118-120.
Cai B., Zhu JH, Hu QL, Ying BL, Wang JL: Immunoeffects of recombinant rabies vaccine on dogs. Chinese
Journal of Zoonoses. (1993) Vol.13(2):118-120.
Suissa S, Ernst P, Benayoun S, Baltzan M, Cai B.: Low-dose inhaled corticosteroids and the prevention of death
from asthma. New England Journal of Medicine (2000) 343(5):332-336.
Ernst P, Cai B, Blais L, Suissa S: The early course of newly diagnosed asthma. Am.J.Med. (2002) 112 (1):44-8.
Watson D, Rhodes T, Cai B., H.Guess: Lower risk of thromboembolic cardiovascular events with naproxen
among patients with rheumatoid arthritis. Archives of Internal Medicine (2002) 162
(10):1105-10.
Contact: bcai@cceb.upenn.edu
Jing Cheng
Admitted: 2002
Education:
MS (Nutrition), Cornell University, 2002
B.M. (Preventive Medicine), West China University of Medical Sciences, 1994
Research Interests:
Causal inference, randomized clinical trials, longitudinal data analysis, sample survey design and analysis
Publications:
Cheng J. and Small D. “Bounds on causal effects in three-arm trials with
noncompliance.'' Submitted to Journal of the Royal Statistical Society, Series B (invited revision).
Small D, Ten Have T, Joffe M, Cheng J. “Random effects logistic models for analyzing efficacy of a longitudinal
randomized treatment with non-adherence.'' Statistics in Medicine. In press.
Yang D., Cheng J. and An Z., "The Principles and Methods to Establish the
Diagnosis Criterion of Primary Osteoporosis", Chinese Journal of Osteoporosis, 1999: 5(2): 36-40.
Contact: jcheng@cceb.upenn.edu
Sumedha Chhatre
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Admitted: 2004
Education:
PhD (Urban Planning), University of Louisville, 2000
MS (International Development), University of Pennsylvania, 1993
BE (Civil Engineering), Bangalore University, India, 1986
Research Interests:
Large database analysis, longitudinal data analysis, randomized clinical trials; survival analysis.
Contact: schhatre@cceb.upenn.edu
Shaokun Chuai
Admitted: 2005
Education:
MS (Biophysics), Institute of Biophysics, Chinese Academy of Science, 2000
MS (Statistics), Texas A&M University, 2002
BS (Biochemistry), Nan-Kai University, 1997
Research Interests:
Statistical genetics, clinical trial design, microarray data analysis, health economics, cancer epidemiology.
Publications:
Kauff ND, Mitra N, Robson ME, Hurley KH, Chuai S, Goldfrank D, Wadsworth E, Lee J, Cigler T, Borgen PI,
Norton L, Barakat RR, Offit K. “Risk of Ovarian Cancer in BRCA1 and BRCA2 Mutation Negative Hereditary
Breast Cancer Families” J Natl Cancer Inst. 2005; 97: 1382-1384.
Mitra N, Ye TZ, Smith A, Chuai S, Kirchhoff T, Peterlongo P, Nafa K, Phillips MS, Offit K, Ellis NA. “Localization
of Cancer Susceptibility Genes by Genome-wide Single-Nucleotide Polymorphism Linkage-Disequilibrium
Mapping” Cancer Res. 2004 Nov 1;64(21):8116-25.
Peterlongo P, Mitra N, Chuai S, Kirchhoff T, Palmer C, Huang H, Nafa K, Offit K, Ellis NA. “Colorectal cancer risk
in individuals with biallelic or monoallelic mutations of MYH” Int J Cancer. 2005 Apr 10;114(3):505-7.
Sarkaria IS, Pham DK, Ghossein RA, Talbot SG, Hezel M, Dudas ME, Ebright MI, Chuai S, Memoli N,
Venkatraman ES, Miller VA, Kris MG, Zakowski MF, Rusch VW, Singh B. “SCCRO Expression Correlates With
Invasive Progression in Bronchioloalveolar Carcinoma” Ann Thorac Surg 2004; 78: 1734-1741.
Liu J, Liu Z, Chuai S, Shen X . (2003) “Phospholipase C and phosphatidylinositol 3-kinase signaling both are
involved in the exogenous arachidonic acid-stimulated respiratory burst in human neutrophils” J.Leukocyte Biol.
Vol.74, No.3.
Contact: schuai@cceb.upenn.edu
Shoshana Daniel
Admitted: 2004
Education:
MS (Biostatistics), Columbia University, 2004
BS (Biological Basis of Behavior), University of Pennsylvania, 2002
Research Interests:
Randomized clinical trials with neurological and genetic applications, specifically in Alzheimer’s and diabetes.
Contact: sdaniel@cceb.upenn.edu
J. Mark Donovan
Admitted: 2000
Education:
MS (Statistics), Northwestern University, 1990
BS (Mathematics), University of Delaware, 1986
Research Interests:
Clinical trials; diagnostics; oncology; clinical trial logistics.
Publications:
Donovan JM, Elliott MR, Heitjan DF (2005). Predicting Event Times in Clinical Trials When Treatment Arm is
Masked. Journal of Biopharmaceutical Statistics, in press.
Hauck FR, Herman SM, Donovan JM, Iyasu S, Merrick Moore C, Donoghue E, Kirschner RH, Willinger M.
(2003). Sleep environment and the risk of sudden infant death syndrome in an urban population: the Chicago
Infant Mortality Study. Pediatrics. 111:5, p. 1207-1214.
Hauck FR, Merrick CA, Donovan M, Herman SM, Kalelkar M, Christoffel KK, Hoffman MA (2002). A
Comprehensive Study of Sudden Unexpected Postneonatal Infant Deaths: The Chicago Infant Mortality Study.
Pediatrics. 110:4, p. 772-80.
Binns HJ, Senturia YD, LeBailly S, Donovan M, Christoffel KK, and the PPRG (1996). Growth of Chicago-area
infants, 1985 through 1987. Not what the reference curves predict. Archives of Pediatrics and Adolescent
Medicine 150:8, p. 842-9.
Senturia YD, Christoffel KK, Donovan M, and the PPRG (1996). Gun storage patterns in U.S. homes with
children. A pediatric practice-based survey. Archives of Pediatrics and Adolescent Medicine 150:3, p. 265-9.
Contact: jdonovan@cceb.upenn.edu
Angelo Elmi
Admitted: 2004
Education:
BS (Mathematics and Economics), State University of New York, Albany, 2003
Research Interests:
Mental health disorders; cancer; genetics; AIDS.
Contact: aelmi@cceb.upenn.edu
Long Long Gao
Admitted: 2000
Education:
MS (Clinical Epidemiology), University of Pennsylvania, 2000
BM (Preventive Medicine), Shanghai Medical University, 1991
Research Interests:
Longitudinal data analysis; clinical trials; noncompliance; missing data.
Contact: lgao@cceb.upenn.edu
Mengye Guo
Admitted: 2003
Education:
MS ( Biostatistics) University of Pennsylvania, 2005
BS (Mathematics), Peking University, 2003
Research Interests:
Developing, implementing and applying Bayesian tests in pharmacogenetics trials in nicotine dependence;
longitudinal data analysis; missing data; design.
Contact: mguo@cceb.upenn.edu
Rachel Hammond
Admitted: 2004
Education:
MS (Mathematics), Drexel University, 2004
BS (Mathematics/Education), Pennsylvania State University, 2001
Research Interests:
Medical research relating to cancer; HIV; Bayesian analysis and MCMC.
Contact: rhammond@cceb.upenn.edu
Carin Kim
Admitted: 2002
Education:
MS (Biostatistics), Columbia University, 2002
MS (Biochemistry and Biophysics), Rensselaer Polytechnic Institute, 1998
BS (Biochemistry and Mathematics), Iowa State University, 1997
Research Interests:
Nonlinear modeling of tumor xenograft data
Contact: cakim@cceb.upenn.edu
Hanjoo Kim
Admitted: 2005
Education:
BS (Statistics), George Washington University, 2005
Research Interests:
Longitudinal data analysis; clinical trials; missing data.
Contact: hkim@cceb.upenn.edu
Michelle Korenblit
Admitted: 2005
Education:
BS (Mathematics/Psychology), Carnegie Mellon University, 2005
Research Interests:
Cancer research; brain imaging with fMRI; microarrays.
Contact: mkorenbl@cceb.upenn.edu
Robert Krafty
Admitted: 2002
Education:
MA (Mathematics), University of Pennsylvania, 2002
BS (Mathematics), SUNY Stony Brook, 2000
Research Interests:
Imaging; spatial statistics; Bayesian modeling and analysis.
Contact: rkrafty@cceb.upenn.edu
Milena Kurtinecz
Admitted: 2005
Education:
MA (Applied Statistics), York University (Toronto), 2002
BS (Mathematics), Babes-Balyai University (Romania), 1997
Research Interests:
Optimal design; dose-response modeling; PK/PD; nonlinear regression.
Contact: mkurtin@cceb.upenn.edu
Benjamin Leiby
Admitted: 2001
Education:
BA (Mathematics), Messiah College, 1998
Research Interests:
Latent-variable and latent-class models; longitudinal data analysis; nonlinear models.
Publications:
Propert, KJ, McNaughton-Collins, M, Leiby, BE, O’Leary, MP, Litwin, MS, and the Chronic Prostatitis
Collaborative Research Network (CPCRN). A prospective study of symptoms and quality of life in men with
chronic prostatitis/chronic pelvic pain syndrome: the NIH Chronic Prostatitis Cohort Study. Journal of Urology.
To appear.
Calhoun EA, Collins MM, Pontari MA, O’Leary MP, Leiby BE, Landis JR, Kusek JW, Litwin MS, the CPCRN.
The Economic Impact of Chronic Prostatitis. Archives of Internal Medicine. 2004; 164(11):1231-6.
Legro RS, Urbanek M, Kunselman AR, Leiby BE, Dunaif A. Self-selected women with polycystic ovary
syndrome reproductively and metabolically abnormal and undertreated. Fertility and Sterility, 78: 51-57, 2002.
Manni A, Fischer S, Franks M, Washington S, De Arment R, Griffith J, Demers L, Verderame M, Leiby B,
Mauger D. S-adenosylmethionine decarboxylase overexpression reduces invasiveness and tumorigenicity in
nude mice of MCF-7 breast cancer cells. International Journal of Oncology 2001; 19: 317-323.
Bixler EO, Vgontzas AN, Lin HM, Ten Have T, Leiby BE, Vela-Bueno A, Kales A. Association of Hypertension
and Sleep-Disordered Breathing. Arch Intern Med. 2000; 160:2289-2295.
Contact: bleiby@cceb.upenn.edu
Caiyan Li
Admitted: 2005
Education:
BS (Mathematics), Peking University, 2005
Research Interests:
Protein secondary structure; genetic analysis.
Contact: cli@cceb.upenn.edu
Julia Lin
Admitted: 2001
Education:
BS (Psychology and Statistics), Carnegie Mellon University, 2000
Research Interests:
Causal models in behavioral health.
Contact: jlin@cceb.upenn.edu
Tao Liu
Admitted: 2003
Education:
MS (Statistics), Iowa State University, 2002
MS (Civil Engineering), Iowa State University, 2001
BS (Environmental Engineering), Tsinghua University, 1999
Research Interests:
Incomplete data; correlated survival data/competing risks; clinical trial design.
Contact: tliu@cceb.upenn.edu
Ziyue Liu
Admitted: 2004
Education:
Master (Medicine), Sun Yat-Sen University, 1997
MS (Biomathematics), North Carolina State University, 2004
Bachelor (Medicine), Sun Yat-Sen University, 1995
Research Interests:
Clinical-related issues.
Contact: zliu@cceb.upenn.edu
Michal Magid-Slav
Admitted: 2004
Education:
MS (Biotechnology), University of Pennsylvania, 2001
MS (Life Science), Weizmann Institute, 1999
BS (Life Science), Tel-Aviv University, 1996
Research Interests:
Statistical methods for genomics and clinical data.
Contact: mmagidsl@cceb.upenn.edu
Roger Mansson
Admitted: 2003
Education:
MS (Mathematical Statistics), Lund University (Sweden), 1998
Research Interests:
Clinical trials; incomplete data; computer intensive methods; longitudinal data analysis.
Contact: rmansson@cceb.upenn.edu
Robin Mogg
Admitted: 2002
Education:
MS (Statistics), University of Wisconsin, 2000
BS (Molecular Biology), University of Wisconsin, 1995
Research Interests:
Statistical methods for longitudinal data; generalized linear mixed models.
Contact: rmogg@cceb.upenn.edu
Michael Rambo
Admitted: 2004
Education:
BS (Mathematics), Alabama A&M University, 2001
Research Interests:
Applications in public health.
Contact: mrambo@cceb.upenn.edu
Kosha Ruparel
Admitted: 2005
Education:
MS (Engineering), University of Pennsylvania, 2004
BS (Engineering), Nirma Institute of Technology, India, 2000
Research Interests:
Applications in clinical trials for brain research.
Contact: kruparel@cceb.upenn.edu
Xiaoli Shi
Admitted: 2005
Education:
BS (Medicine), Peking University, 2002
Research Interests:
Clinical trial design and analysis; statistical genetics; longitudinal data analysis.
Contact: xshi@cceb.upenn.edu
Wenguang Sun
Admitted: 2003
Education:
MS ( Biostatistics) University of Pennsylvania, 2005
BS (Statistics), Peking University, 2003
Research Interests:
Longitudinal data analysis; Bayesian methods; nonparametric modeling.
Contact: wsun@cceb.upenn.edu
Valerie Teal
Admitted: 2004
Education:
MS (Material Sciences and Engineering), Massachusetts Inst. of Technology, 1984
BS (Material Sciences and Engineering), Massachusetts Inst. of Technology, 1983
Research Interests:
Randomized clinical trials; mental health; aging.
Contact: vteal@cceb.upenn.edu
Peter Wahl
Admitted: 2004
Education:
MLA (Liberal Arts), University of Pennsylvania, 2004
BA (Economics), Cornell University, 1992
Research Interests:
Randomized clinical trials in cancer; cost-effectiveness analysis; microarrays.
Publications:
Bavaria JE, Pochettino A, Kotloff R, Rosengard BR, Wahl PM, Palevsky H, Kaiser LR. Effect of Volume
Reduction on Lung Transplant Timing and Selection for COPD. J Thorac Cardiovasc Surg 1998;115:9-18.
Shrager JB, Kim DK, Hashmi YJ, Lankford EB, Wahl P, Stedman HH, Levine S, Kaiser LR. Lung Volume
Reduction Surgery Restores the Normal Diaphragmatic Length-Tension Relationship in Emphysematous Rats. J
Thorac Cardiovasc Surg 2001:121(2):217-24.
Bloom BS, Jayadevappa R, Wahl P, Cacciamani J. Time Trends in Cost of Caring for People with
Gastroesophageal Reflux Disease. Am J Gastroent 2001; 96(8) [Suppl]:S64-9.
Kesmodel SB, Karakousis GC, Botbyl JD, Canter RJ, Lewis RT, Wahl PM, Alavi A, Elder DE, Ming ME, Guerry D,
Gimotty PA, Fraker DL, Czerniecki BJ, Spitz FR. Mitotic Rate as a Predictor of Sentinel Lymph Node Positivity in
Patients with Thin Melanomas. Ann Surg Onc 2004; 12(6): 1-10.
Gimotty PA, Guerry D, Ming M, Xu X, Wahl PM, Hotz S, VanBelle P, Raines S, Elder DE. The Biologic and
Prognostic Significance of Ki67 Expression, Mitotic Rate and Tumorigenicity in Thin Invasive Cutaneous
rd
Melanoma. Presented in part at the 93 Annual Meeting of the American Association for Cancer Research, San
Francisco CA, April 2002 and submitted to the J Clin Onc February 2005.
Contact: pwahl@cceb.upenn.edu
Hong Wan
Admitted: 2005
Education:
MS (Ecology), Peking University, 2001
MS (Biostatistics), University of Minnesota, 2004
BS (Biology), Peking University, 1998
Research Interests:
Clinical trials; breast cancer.
Contact: hwan@cceb.upenn.edu
Chia-Hao Wang
Admitted: 2005
Education:
BS (Computer Science), Rutgers University, 2005
Research Interests:
Breast cancer research.
Contact: cwang@cceb.upenn.edu
Hao Wang
Admitted: 2004
Education:
MS (Statistics), University of California, Davis, 2000
MS (Chemistry), Institute of Chemistry, Chinese Academy of Sciences, 1994
BS (Chemistry), Wuhan University, 1991
Research Interests:
Adaptive design of dose escalation trials; outcomes research; Bayesian statistics; methods for longitudinal and
correlated data; biomarkers.
Publications:
Rogatko, A, Babb, JS, Wang H, Slifker, MJ, Hudes, GR. Patient Characteristics Compete with Dose as Predictors
of Acute Treatment Toxicity in Early Phase Clinical Trials. Clin Cancer Res. 2004;10(14):4645-51
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Schonll RA, Rothman RL, Wielt DB, Lerman C, Pedri H, Wang H, Babb J, Miller SM, Movsas B, Sherman E,
Ridge JA, Uger M, Langer C, Goldberg M, Scott W, Cheng J. A randomized pilot study of cognitive-behavioral
therapy versus basic health education for smoking cessation among cancer patients. Ann Behav Med.
2005;30(1):1-11.
Berger AC, Farma J, Scott WJ, Freedman G, Weiner L, Cheng JD, Wang H, Goldberg M. Complete Response to
Neoadjuvant Chemoradiotherapy in Esophageal Carcinoma Is Associated With Significantly Improved Survival. J
Clin Oncol. 2005;23(19):4330-7
Carlini LE, Meropol NJ, Bever J, Andria ML, Hill T, Gold P, Rogatko A, Wang H, Blanchard RL. UGT1A7 and
UGT1A9 Polymorphisms Predict Response and Toxicity in Colorectal Cancer Patients Treated with
Capecitabine/Irinotecan. Clin Cancer Res. 2005;11(3):1226-36.
Cheng JD, Valianou M, Canutescu AA, Jaffe EK, Lee HO, Wang H, Lai JH, Bachovchin WW, Weiner LM.
Abrogation of fibroblast activation protein enzymatic activity attenuates tumor growth. Mol Cancer Ther.
2005;4(3):351-60.
Contact: hwang@cceb.upenn.edu
Xiaoying Wu
Admitted: 2005
Education:
MS (Computer Science), Drexel University, 2003
BS (Medicine), Xiangya School of Medicine, Central South University, 1996
Research Interests:
Statistical computing; imaging; longitudinal analysis; clinical trials.
Publications:
C. Davatzikos, D. Shen, R.C. Gur, X. Wu, F. Yong, P. Hughett, B.I. Turetsky and R.E. Gur, “Whole-Brain
Morphometric Study of Schizophrenia Reveals a Spatially Complex Set of Focal Abnormalities”, Arch Gen
Psychiatry. 2005; 62:1218-1227
Contact: xwu@cceb.upenn.edu
Lingfeng Yang
Admitted: 2002
Education:
MS (Biostatistics), University of Minnesota, 2002
BS (Genetics), Fudan University, 1998
Research Interests:
Latent class modeling; clinical trials; correlated data analysis.
Publications:
Vaccaro O, Eberly LE, Neaton JD, Yang L, Riccardi G, and Stamler J.,
Impact of Diabetes and Previous Myocardial Infarction on Long-term Survival: 25-Year Mortality Follow-up of
Primary Screenees of the Multiple Risk Factor Intervention Trial, Archives of Internal Medicine, 164: 1438 –
1443, 2004
Eberly LE, Ockene J, Sherwin R, Yang L, and Kuller L. Pulmonary function as a predictor of lung cancer
mortality in continuing cigarette smokers and in quitters, International Journal of Epidemiology, 32(4):592-599,
2003.
Eberly LE, Cohen JD, Prineas R, and Yang L. The impact of incident
Diabetes Mellitus and incident non-fatal cardiovascular disease on 18
year mortality: The Multiple Risk Factor Intervention Trial experience,
Diabetes Care, 26(3):848-854, 2003.
Contact: lyang@cceb.upenn.edu
Huaging Zhao
Admitted: 2002
Education:
MA (Applied Statistics), University of Pittsburgh, 1993
BS (Management), Jilin Institute of Engineering, 1986
Research Interests:
Compliance in longitudinal clinical trials; predictive modeling; diagnostic tests.
Publications:
Cnaan A, Zhao H, Silber JH: Measuring compliance and its effect on analyses in longitudinal clinical trials. ASA
Proceedings of the Section on Biometrics. P591-595, 2002.
Aplenc R, Zhao H, Rebbeck TR, Propert KJ: Group sequential methods and sample size savings in biomarkerdisease association studies. Genetics 163: 1215-1219, 2003.
Smith-Whitley K, Zhao H, Hodinka RL, Kwiatkowski J, Cecil R, Cecil T, Cnaan A, Ohene-Frempong K: The
epidemiology of human arvovirus B19 in children with sickle cell disease: Blood. 103(2):422-7, 2004.
Silber JH, Cnaan A, Clark BJ, Paridon SM, Chin AJ, Rychik J, Hogarty AN, Cohen MI, Barber G, Rutkowski M,
Kimball TR, Delaat C, Steinherz LJ, Zhao H: Enalapril to prevent cardiac function decline in long-term survivors of
pediatric cancer exposed to anthracyclines. Journal of Clinical Oncology 22(5):820-8, 2004.
Morowitz MJ, Barr R, Wang Q, King R, Rhodin N, Pawel B, Zhao H, Erickson SA, Sheppard GS, Wang J, Maris
JM, Shusterman S.: Methionine aminopeptidase 2 inhibition is an effective treatment strategy for neuroblastoma
in preclinical models. Clin Cancer Res. 2005 Apr 1;11(7):2680-5.
Contact: hzhao@cceb.upenn.edu