1. No category

Cover Sheet for Bids
(All sections must be completed)
Name of JISC Initiative:
Universities Modernisation Fund Cloud Computing
Programme
Name of Lead Institution:
University of Leicester
Name of Proposed Project:
BRISSkit: Biomedical Research Infrastructure Software
Service kit
Name(s) of Project Partners(s)
University Hospitals Leicester Trust
(except commercial sector – see below)
This project involves one or more
commercial sector partners
YES
Name(s) of any commercial partner company(ies)
Obiba Software Foundation; Charles Beagrie Consultants
Full Contact Details for Primary Contact:
Name:
Dr Jonathan Tedds
Position: Senior Research Liaison Manager
Email:
jat26@leicester.ac.uk
Tel:
01162525287
Address: IT Services, Computer Centre, University of Leicester, Leicester LE1 7RH
Length of Project:
12 months
Project Start Date:
1st April 2011
Total Funding Requested from JISC:
Project End
Date:
31st March 2012
£816,096
Funding requested from JISC broken down across Financial Years (Apr-March)
Apr11 – March12
£816,096
Total Institutional Contributions:
£48,875
Outline Project Description
BRISSkit will develop a national shared service brokered by JANET to host, implement and deploy
biomedical research database applications that support the management and integration of tissue
samples with clinical data and electronic patient records. We are uniquely positioned to tackle this
through our experience in developing the pioneering open source IT infrastructure for the
Biomedical Research Informatics Centre for Cardiovascular Science in the NIHR Leicester
Cardiovascular Biomedical Research Unit (BRU). Anonymised versions of patient sensitive
databases are hosted for University researchers on a VMware platform implemented by the
University of Leicester IT Research Computing Service. We will work across the range of
stakeholders in clinical, University and international biomedical research to deploy appropriate,
secure, affordable and reliable services in this key strategic area for the UK.
I have looked at the example FOI form at Appendix A YES
and included an FOI form in this bid
I have read the Funding Call and associated Terms
and Conditions of Grant at Appendix B
For FE institutions only: Please tick this box if you
are an FE institution in England, please tick this
box to confirm that you meet the eligibility
requirement of teaching HE to more than 400 FTE
o
o
1
YES
1. University of Leicester IT Strategy and the JISC University Modernisation Fund Cloud
Computing Programme
1.1.
The University of Leicester (UoL) and University Hospitals Trust Leicester (UHL) believe that the
effective management of research data is a critical success factor. We recognise the huge opportunity that
could result from more effective sharing and dissemination of data across biomedical research disciplines
and between institutions and other Hospital Trusts. We also note the potential of cloud based infrastructure
and shared services to contain costs and are keen to demonstrate that these opportunities can be exploited
in a secure manner without exposing our organisations to significant risk. We therefore warmly welcome
the JISC University Modernisation Fund (UMF) Cloud Computing Programme and wish to build on current
working prototypes created for our Biomedical Research Informatics Centre for Cardiovascular Science
(BRICCS) project 1 to create a full production service in a shared services/cloud environment for the benefit
of the whole biomedical research sector.
1.2.
The University of Leicester has already taken a number of strategic actions to support the research
data management needs of its researchers and promote the long-term preservation and dissemination of
the data they produce. It has also given its central IT Service a clear mandate to provide comprehensive
information management services to underpin all aspects of the University’s mission, including its research,
in the most cost-effective manner possible.
1.3.
Within the central IT Service, it has created a ‘Research Computing Services’ (RCS) team (in 2008)
whose aim is to support the needs of researchers in particular. This is now staffed with six IT professionals
(all with research backgrounds) and one full-time project manager. The team launched a new £2m High
Performance Computing facility in 2010 and has gone on to pilot various server and database hosting
services on a ‘local cloud’ of virtualised infrastructure including for the BRICCS project which is the subject
of this proposal.
1.4.
The University was a Pathfinder for the UK Research Data Service (UKRDS). This provided an
excellent opportunity to engage a wide range of researchers in requirements gathering and generate
enthusiasm for solving the data management challenge at Leicester. Through this initiative we have
established the role of ‘Research Liaison Manager’ which has built effective relationships with a wide range
of research teams and helped us to identify, define and prototype the services that they need at institutional
level. One such example is the LAMP Hosting Service which provides a common infrastructure stack
(Linux, Apache, MySQL and PHP) running on VMWare for hosting research applications. This is the
proposed infrastructure for the project which is the subject of this proposal.
1.5.
The services implemented or envisaged have been agreed within the regular governance structure
of the institution through the Research Computing Management Group, chaired by the PVC Research &
Enterprise (Prof Kevin Schurer) and its parent group the Information and Communications Technology
Committee.
1.6.
The Research Liaison Manager has also developed a keen understanding of the cultural issues and
other inhibitors that could prevent the exploitation of services that are, or will be, available nationally or
internationally.
1.7.
The University’s governing body has also highlighted the need to ensure the integrity of its research
data, particularly where that data is sensitive. Another key role of the IT Research Liaison Manager has
been to map sensitive and confidential data across the institute in order to prioritise where intervention and
support is needed most urgently and develop a co-ordinated and rigorous institutional policy having wider
application nationally.
1
http://www2.le.ac.uk/projects/bru/researchers/briccs
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o
2
1.8.
The JISC MRD funded interdisciplinary HALOGEN project made a good template for effective
partnership with the research community and successfully engaged the Wellcome Trust in practical
endorsement of its aims. The HALOGEN project (History, Archaeology, Linguistics, Onomastics and
GENetics) supported the data management needs of the researchers involved and thus provided a context
in which to establish organisational best practice in terms of the storage and management of diverse crossdisciplinary research data. The project covered all phases of the project life cycle from requirements
analyses through to the implementation of a practical, cost effective solution to meet the needs of the
research team for data access, sharing, curation and preservation. The solution was designed to exploit the
existing research storage assets within the University in terms of hardware, software and technical
expertise both within IT Services and other centres of excellence within the University. Extensive use of
DCC developed tools was made and, through collaboration with other Pathfinder institutions, policies,
procedures and organisational constructs were implemented in an emerging coherent national framework.
2. The University Hospitals Leicester Trust (UHLT) and the BRICCS project
2.1.
The Biomedical Research Informatics Centre for Cardiovascular Science (BRICCS): BRICCS is a
core component of the NIHR Leicester Cardiovascular BRU, itself a joint initiative of the UoL and the
UHLT2. BRICCS aims to capture and code clinical information about patients with cardiovascular disease
seen in UHL specifically for research purposes and for facilitating recruitment of patients into new studies.
A database of cardiovascular samples will be combined with patient records and related research data in a
secure Hospitals Trust database. The University in turn hosts an anonymised mirror of this dataset for use
by University researchers, updated nightly, using the LAMP Hosting Service originally designed for a
smaller scale bioinformatics research computing cluster in Genetics and developed to support the JISC
MRD Halogen database. BRICCS initial emphasis was on setting up sample tracking software and the
storage and annotation of the data sets in a simple, user friendly form for a range of Trust and University
researchers.
2.2.
UHLT already collects a large amount of information on patients, both of a generic nature and more
detailed information on specific groups of interest. BRICCS has developed a dedicated research database
with a core set of information on each subject, including known cardiovascular conditions and risk factors,
and establish linkages with other databases, including results of hospital investigations, to primary care and
to national registers. The programme was rolled out initially over two years from late 2009. The Trust sees
this development as a key component of its future R&D strategy and as a forerunner of similar
developments in other disease areas.
2.3.
The BRICCS development team is led academically by Prof Leong Ng who has considerable
relevant experience, having developed the Leicester CCU research database over the last 15 years on
over 10,000 subjects (e.g. Blackledge et al. BMJ 2003; Khan SQ et al. Circulation 2007). Prof Paul Burton
who has vast experience in the design and harmonization of large scale databases and clinical biorepositories, including UK Biobank and FP6 funded PHOEBE project will play a key advisory role. A senior
Trust manager with IMT expertise (Maureen Collins, seconded full-time) will manage the Trust team within
project.
2.4.
The Leicester Cardiovascular Bioresource (LCB) is being developed in parallel with BRICCS to
collect and store plasma, DNA and other biological samples (e.g. vascular tissues) from selected groups of
patients being investigated and treated in UHLT. It is planned to collect, in the first 5 years, in excess of
20,000 new samples, each linked to patient information available via BRICCS. Given its scale and the
mixed ethnic population base, LCB will become a major resource, contributing both to our local
programmes (particularly in genomics), as well as building national capacity in this field.
2.5.
As in the case of BRICCS, development of LCB will be managed by a dedicated team headed by an
academic (Prof Alison Goodall) and supported by a full-time scientific manager funded by the University
(Manish Maisuria). LCB follows best practice for tissue banks, as defined in international guidelines such as
those of the Confederation of Cancer Biobanks (http://www.ncri.org.uk/ccb).
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3. Proposal and Work Plan
3.1.
Project Objectives
3.1.1. The primary objective is to design, deliver and begin to exploit a data hosting service for
researchers in the field of Bioinformatics. Sensitive, attributable clinical data will be hosted on infrastructure
managed by UHLT. De-identified versions of this data will be replicated to a cloud based infrastructure and
made available to researchers. This will establish best practice for similar initiatives both within the
UoL/UHLT and nationally.
3.1.2. In achieving this, the following additional learning objectives will be met.

A service delivery model and policies for supporting successful research using this approach will be
established.

The costs and benefits of undertaking research using this service will be established

The strengths, weaknesses, threats and opportunities associated with using this approach will be
assessed
3.2.
Partners and Methodology
The solution will be developed collaboratively to meet the requirements of the UoL Departments of
Cardiovascular Sciences, Genetics & Health Sciences as well as the UHLT. Maximum benefit will also be
gained by sharing experience with others notably the DCC and the other institutions who are part of the
UMF cloud computing programme, brokered by Charles Beagrie Ltd.
4. Timetable of Technical Work Packages and Deliverables
Months 
04 05 06 07 08
Workpackage 
11 11 11 11 11
WP1 – Project Management
Project set-up and detailed project plan
D1.1
Six monthly report and revised project plan
JISC Programme level activity and
reporting to funder; final report
WP2 – Project infrastructure
Code repository, automatic build system,
D2.1
web sites, issue tracking
Virtual Machine test facilities
D2.2
WP3 – Deployment Infrastructure
Deployment Architecture Document
D3.1
Artifact repository for auto-deployment use
D3.2
(project test version only)
Generic System Administration Programs,
D3.3
Scripts and Facilities for auto deployment
09
11
Revised Deployment Architecture
Document
11
11
12
11
01
12
02
12
03
12
D1.2
D1.3
D3.4
WP4 – Tissue Management “in a box” (Target Application: caTissue)
Developing the use case: submission of
D4.1
multiple samples (already prototyped)
Package the API developed in D4.1 so it is
D4.2
o
o
10
11
4
Months 
04 05 06 07 08 09 10
Workpackage 
11 11 11 11 11 11 11
extensible to other collection protocols
Customization for the UK locale
Deployment Scripts for auto deployment
D4.4
Document the integration of laboratory
D4.5
equipment
Enable the grid aspect of caTissue
WP5 – Data Capture “in a box” (Target Applications: Onyx and REDCap)
Packaged Ontology
D5.1
Principles and Practices of Questionnaire
Design Document
Package existing design tools (onyx GUI
D5.3
questionnaire builder)
Components for Data Export (driven by
D5.4
Ontology)
Deployment Scripts for auto deployment
D5.5
WP6 – Data Capture from Clinical Systems (into the Data Warehouse)
Define standard web services for export
D6.1
Provide example web services for export /
import
Document use of the packaged ontology
WP7 – Biomedical Data Warehouse “in a box” (Target Application: i2b2)
Server side customization for the UK locale
D7.1
Client customization for the UK locale:
D7.2
workbench and web client
Deployment Scripts for auto deployment
D7.3
Enhance forthcoming ontology pull cell for
UK, to use TRUD
Component pipeline with web services for
Data Import (driven by Ontology)
WP8 - E3 “End-to-End engineering”
Integration of caTissue with i2b2
D8.1
Revised Deployment Architecture
Document for clinical contexts
Revised deployment procedures for clinical
contexts
Glue scripts for complete end-to-end install
of components
Glue scripts for daily end-to-end running of
the system
Facilitating Data sharing – SHRINE
WP9 – Evaluation and Deployment
Workshop-1 with infrastructure providers.
D9.1
Any one component. Deploy & use in day.
Workshop-2 with domain users: Tissue
Management. Deploy & use in day.
Workshop-3 with domain users: Data
Capture. Deploy & use in day.
Workshop-4 with domain users: Data
Warehouse. Deploy & use in day.
o
o
5
11
11
12
11
01
12
02
12
03
12
D4.3
D4.6
D5.2
D6.2
D6.3
D7.4
D7.5
D8.2
D8.3
D8.4
D8.5
D8.6
D9.2
D9.3
D9.4
Months 
Workpackage 
Workshop-5 with infrastructure providers.
All components. Deploy & use in day.
Setup repository and install components
with infrastructure providers.
Packaged documentation plus multimedia
HOWTO videos.
4.1.
04
11
05
11
06
11
07
11
08
11
09
11
10
11
11
11
12
11
01 02
12 12
D9.5
03
12
D9.6
D9.7
List of Technical Deliverables
D3.1: Deployment Architecture Document [end 31.5.11]
D3.2: Artifact repository for auto-deployment use (project test version only) [end 13.5.11].
D3.3: Generic System Administration Programs, Scripts and Facilities for auto deployment [end 13.7.11]
D4.1: Developing the use case: submission of multiple samples [end 27.7.11]
D4.2: Package the API developed in D4.1 so it is extensible to other collection protocols [end 25.8.11]
D4.3: Customization for the UK locale [end 28.12.11]
D4.4: Deployment Scripts for auto deployment [end 28.6.11]
D4.5: Document the integration of laboratory equipment [end 2.9.11]
D4.6: Enable data sharing via grid for caTissue [end 5.1.12]
D5.1: Packaged Ontology [end 29.9.11]
D5.2: Principles and Practices of Questionnaire Design Document [end 1.12.11]
D5.3: Package existing design tools [end 8.8.11]
D5.4: Components for Data Export [end 5.9.11]
D5.5: Deployment Scripts for auto deployment [end 4.7.11]
D6.1: Define standard web services for export [end 5.8.11]
D6.2: Provide example web services for export / import [end 2.11.11]
D6.3: Document use of the packaged ontology [end 6.12.11]
D7.1: Server side customization for the UK locale [end 5.8.11]
D7.2: Client customization for the UK locale: workbench and web client [end 12.10.11]
D7.3: Deployment Scripts for auto deployment [end 4.7.11]
D7.4: Enhance forthcoming ontology pull cell for UK, to use TRUD [end 2.11.11]
D7.5: Component pipeline with web services for Data Import (driven by Ontology) [end 9.1.11]
D8.1: Integration of caTissue with i2b2 [end 8.9.11]
D8.2: Revised Deployment Architecture Document for clinical contexts [end 10.2.12]
D8.3: Revised deployment procedures for clinical contexts [end 10.2.12]
D8.4: Glue scripts for complete end-to-end install of components [end 15.3.12]
D8.5: Glue scripts for daily end-to-end running of the system [end 15.3.12]
D8.6: Facilitating Data sharing – SHRINE [end 15.3.12]
4.2.
Project Management and Governance
4.2.1. The project will be managed using the PRINCE2 methodology in line with UoL project management
standards with additional reporting on a six-monthly basis to align with JISC requirements.
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4.2.2. The core Project Team will be coordinated by Dr Jonathan Tedds (PI) and work under the direction
of Mary Visser (Director, ITS) and Dr Chris Rudge (Manager, Research Computing Services ITS). The
technical project will be managed by a full-time Senior Project Manager in IT Services for UoL (David
Carter) and will include key personnel from each partner and department involved as below.
4.2.3. Design and delivery of the solution will be undertaken by staff with relevant expertise as below (a
total of approximately 10.6 FTE over 12 months).
4.2.4. Regular reviews will be undertaken of progress, actions, risks, issues, deliverables and plans with
reports to the Project Board. The Team will meet at least fortnightly or as required. The membership of the
technical team will flex in line with the demands of the project. Information on key staff that will support the
requirements analyses and design phases is detailed in the table below.
Name
Dr Jonathan
Tedds
Project Role
PI and
Project
Coordinator
David Carter
Project
Manager
Jeff Lusted
Senior Java
Programmer
Dr Jon
Wakelin
Dr Chris
Rudge
Software
Developer
Research
Computing
Services
Manager
Database
Architect
Web
Services
Architect
Research to
Clinical
Ontological
mapping
Liam Gretton
Stuart
Poulton
Dr Tim Beck
Dr Rob Free
Clinical
database
architect
Carl Nelson
Maureen
Collins
Data Security
specialist
UHLT IT
architect
Manish
Manager
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Experience
>18 years experience in research; managed UK and EU FP6 work
programmes to develop e-science research tools for astrophysics users
at UoL and other European Space Agency funded universities.
Currently Senior Research Liaison Manager with UoL IT Services.
>20 years with a successful track record as an IT infrastructure
Programme Manager in the commercial sector. Qualified in PRINCE2.
Project managed the implementation of the new High Performance
Computing Service (c. £2M CIF funded initiative) and Halogen JISC
MRD project.
Has spent the last year on the BRICCS project. 6 years on the UK escience AstroGrid project and JISC AGAST project. Prior to that he
worked for IBM Global Services. He has been associated with database
systems since the early 1980's.
>5 years experience in software development as a researcher followed
by roles in supporting researchers at the University of Bristol, now UoL.
>10 years experience providing research computing infrastructure and
support for astronomy researchers at Leicester and nationally and also
wider support to researchers at the University of Leicester. Manager of
the Research Computing Services team in IT Services
>5 years experience of technical infrastructure design in complex
technical environments.
>10 years as a Web information and database architect and designer.
Experience in supporting projects with complex datasets
Postdoctoral Research Fellow (Genetics): >7 years experience in
mapping of research to clinical ontologies/vocabularies. Use of
phenotype (disease related) ontologies and controlled vocabularies in a
research including Medical Subject Headings (MeSH) and the Human
Phenotype Ontology (HPO). Use of NLM Unified Medical Language
System (UMLS) including SNOMEDCT ontology used in BRICCS.
Postdoctoral Research Fellow (Genetics): >5 years experience
visualization/graphical tools for interrogating and integrating one or
more data-sets; creating and modifying existing tools for advanced data
mining. In clinical data field developed a tuberculosis clinical
notifications system to integrate patient and specimen data from the
Patient Master Index and UHLT databases.
>20 years in IT with special responsibility for data security in UoL IT
Services
Programme manager for systems integration, data warehousing and
business intelligence within the UHLT IM&T team. Working in
collaboration with the BRU to supply data from the applications around
the Trust in support of the BRICCS research project.
Department Manager in the Department of Cardiovascular Sciences.
7
Maisuria
Cardiovascul
ar Sciences
Based at Glenfield Hospital he will be responsible for the interface
between academic and technical expertise on the side of both the UHL
Trust and the University.
Dave Morris
Senior
Developer
7 years experience developing the cloud-compute based infrastructure
for automatic deployment and testing of UK e-science AstroGrid
services; use of Amazon EC2, FlexiScale, SliceHost, RackSpace and
ByteMark commercial cloud-compute services. Deployment and
managing of virtual machines using the Linux KVM virtualization tools. 6
months working with the BRICCS project to develop automatic
installation and deployment tools to deploy the BRICCS data services
onto the VMware virtual machine infrastructure provided by ITS-RCS.
4.2.5. The Project Board will meet in line with key management decision points throughout the project
and will be reviewers and signatories for all major deliverables starting with the Project Initiation Document.
Name and positions
Prof Nilesh Samani (Executive)
British Heart Foundation Professor of
Cardiology in the University and
Honorary Consultant Cardiologist in
the Trust and is the Director of the
LCBRU
Prof Anthony Brookes (Senior
User)
Professor of Bioinformatics and
Genomics, Department of Genetics
Prof Alison Goodall (Senior User)
Professor, Department of
Cardiovascular Sciences
Mary Visser (Senior Supplier)
Director of IT Services
Prof Paul Burton (Senior User)
Professor of Genetic Epidemiology
Neil Beagrie (National Consultant)
Director of consultancy at Charles
Beagrie Ltd
Prof Leon Ng (Senior User)
Professor of Medicine and
Therapeutics and Honorary
Consultant Physician
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Remit and contribution
 Chair of Project Board
 Overall institutional direction and engagement
 Fellow of the Academy of Medical Sciences and amongst the first
100 NIHR Senior Investigators.
 Internationally recognised for his work on the genetics of
coronary disease and hypertension.
 Bioinformatics research using anonymised clinical datasets
 Innovating and improving technologies for the experimental study
of DNA variation in relation to cancer and other disorders
 Devising next-generation approaches towards web-based data
management of complex information emerging from the global
study of DNA variation in disease contexts.
 LCBRU Principal Investigator
 Knowledge and experience in cardiovascular research
requirements and departmental direction and issues
 IT strategy, policy guidance
 Supplier of implementation and support services
 Internationally recognised for his work in statistical genetics;
design and harmonization of large scale population-based
biobanks and clinical bio-repositories.
 Science Coordinator of the FP6 PHOEBE project (Promoting
Harmonization of Epidemiological Biobanks in Europe)
 Chief Scientific Officer and Chair of the Executive Steering
Committee of P3G - the international organisation aimed at
harmonizing population-based biobanks across the globe.
 Co-lead on the DataSHaPER project (Data Schema and
Harmonization Platform for Epidemiological Research)
 Experienced senior consultant and an internationally recognised
expert in digital curation
 Extensive experience with research data, cost/benefit analysis,
business planning and sustainability.
 Leader in the field of novel biomarkers in cardiac disease
 Strong collaborations with industry in developing near-patient or
laboratory assays based on these findings.
 Established one of the largest Coronary Care Unit databases
8
Name and positions
Prof Iain Squire (Senior User)
Professor of Cardiovascular Medicine
& Honrary Consultant Physician
 Representative or nominee of JISC as the project funder
Funding Body Member
4.3.
Remit and contribution
 UK co-ordinator of a Europe-wide Cardiac Resynchronisation
Registry, on behalf of the Heart Failure Association and Heart
Rhythm Society of the European Society of Cardiology
 Editorial boards : British Journal of Clinical
Pharmacology International Editorial Board, 2000-2004
 Clinical Science Editorial Advisory Board August 2006-current
Risk Analysis
No
Risk
Probability Impact
Staffing not in place at
1
low
low
project start
Absence, illness or
2 loss of key staff during
the project
low
Scope of project overambitious
high
3
Lack of buy-in,
engagement or
4
commitment from
internal stakeholders
5
4.4.
Technology-related
failures
low
low
Mitigation
 Key project directing/managing staff already in post
both in UoL and UHLT.
 A ‘pool’ of analysts and technical resource exists
within IT Services the workload of these could be
reprioritised to support this initiative.
low
 Team-based culture with collaborative practice to
share learning and knowledge amongst team
members.
 Strong Project Board involvement to provide realistic
and pragmatic project guidance.
medium
 Early refinement of work packages in consultation with
stakeholders represented on Project Board.
high
 Very high level commitment in UoL, UHLT, JISC
 Strategic importance of developing integrated
approach recognised
low
 Experienced in-house technical resource to help with
design and implementation of technical solutions.
 Can exploit existing data management infrastructure
within IT Services and UoL if external problems.
 The evaluation criteria for any new infrastructure
components will be weighted to reflect the need for
‘well proven’ and ‘robust’ solutions
IPR
4.4.1. With the exception of potentially sensitive commercial, budgetary and personnel information, the
UoL offers a non-exclusive licence to JISC and its representatives to utilise, archive and disseminate any
documentation produced as part of this project. This information will be made available in the public
domain via the project website and via regular project reports to JISC. Technical developments will be
licensed as open source where appropriate and will be made available to the JISC and the wider
educational community.
5. Budget
Apr 11 –
Mar 12
Directly Incurred Staff
UHLT Senior IT Architect (Collins)
@ 1.0 FTE
UHLT BRICCS Senior IT Consultant (Morris)
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o
9
TOTAL £
@ 0.2 FTE
Charles Beagrie Consultants
Neil Beagrie @15 days + junior @ 20 days
Postdoctoral Research Fellow (Beck)
@ 0.5 FTE
Postdoctoral Research Fellow (Free)
@ 0.5 FTE
Total Directly Incurred Staff (A)
Non-Staff
Travel and expenses
Travel for Project Board members ( 1 external
Board member)
Travel for project staff to support programme
activity
Hardware/software
Servers, storage, backup, maintenance and
network connectivity (UoL)
Servers, storage, backup, maintenance and
network connectivity (UHLT)
OBiBa OS software development
Dissemination
Online dissemination media set-up
Conference dissemination (~10 staff to 2
conferences over life of project)
Other
Room & refreshments for Project meetings
Consumables
Total Directly Incurred Non-Staff (B)
Directly Incurred Total (C)
(A+B=C)
Directly Allocated
Staff
Senior ITS Research Liaison Manager (Tedds)
@ 1.0 FTE
Senior Project Manager (Carter)
@ 1.0 FTE
ITS Research Computing Services (RCS) Team
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o
10
Manager (Rudge)
@ 0.1 FTE
ITS RCS Software Architect (Wakelin)
@ 1.0 FTE
ITS RCS Database Architect (Gretton)
@ 1.0 FTE
ITS RCS Web Service Architect (Poulton)
@ 1.0 FTE
ITS RCS Senior Java Programmer (Lusted)
@ 1.0 FTE
UoL Cardiovascular IT Manager (Maisuria)
@ 1.0 FTE
ITS Senior Data Security Specialist (Nelson)
@ 0.2 FTE
Prof N. Samani, Clinical Professor Banded
@ 0.2 FTE
Prof A. Goodall, Professor @ 0.2 FTE
Prof A. Brookes, @ 0.05 FTE
Prof L. Ng, Clinical Professor @ 0.2 FTE
Prof P. Burton, Clinical Professor @ 0.05 FTE
Prof. I. Squire, Clinical Professor @ 0.2 FTE
Mary Visser, Director ITS, @ 0.05 FTE
Estates
£25,991.96
£25,991.96
Other – total pooled Lab Techs
£5,161.32
£5,161.32
Directly Allocated Total (D)
£557,952
£557,952
Indirect Costs (E)
£71,758
£71,758
Total Project Cost (C+D+E)
£864,971
£864,971
Amount Requested from JISC:
£816,096
£816,096
Institutional Contributions
£48,875
£48,875
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11
Percentage Contributions over the life of the
project
No. FTEs used to calculate indirect and estates
charges, and staff included
A cumulative 1.95 FTE or 195% FTE has been
used to calculate estates and indirect costs.
JISC %
Partners %
Total
94.35%
5.65%
100%
No FTEs
Which Staff
1.95 FTE or 195% FTE
All members of staff
(directly incurred and
allocated) are included in
the costs.
5.1.1. To ensure a rapid start staffing will be allocated with immediate effect and backfilled if necessary. All
key personnel are identified and already in post.
6. Engagement with the community, milestones and sustainability
Engaging expert external consultancy from Charles Beagrie Ltd in developing business planning and
sustainability we will work to the following key milestones:
Timing
Factors to evaluate
Measures of success
June 2011
Detailed project plan (1.1)
VM Test facilities (2.2)
Artifact repository (3.2)
caTissue deployment mechanism (4.4)
Exists
Operational
Exists
Deployed and tested
September 2011
Generic deployment infrastructure (3.3)
caTissue API client (4.2)
Data generation tools (5.4)
Data warehouse application (7.3)
UK customisations (7.1)
Integration of caTissue / i2b2 (8.1)
Provision of workshops (9.1)
Exists
Available for use
Data available for export
Deployed
Complete
Available
Scheduled
January 2012
Revised project plan (1.2)
UK cstomisation of caTissue (4.3)
Grid deployment of caTissue (4.6)
Principles of Questionnaire Design (5.2)
Data capture from clinical systems (6.3)
Ontology pull cell for i2b2 (7.4)
Clinical deployment guide (8.2)
Clinical deployment tools (8.3)
Provision of workshops (9.2 – 9.5)
On schedule to revised plan
Integrated into core code
Grid available
Documented
Documented
Accesses alternative sources
Documented
Underway
Scheduled
o
o
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