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From www.bloodjournal.org by guest on October 28, 2014. For personal use only. 2014 124: 2617-2754 124 (17) Updated information and services can be found at: http://www.bloodjournal.org/content/124/17.full.html Articles on similar topics can be found in the following Blood collections Information about reproducing this article in parts or in its entirety may be found online at: http://www.bloodjournal.org/site/misc/rights.xhtml#repub_requests Information about ordering reprints may be found online at: http://www.bloodjournal.org/site/misc/rights.xhtml#reprints Information about subscriptions and ASH membership may be found online at: http://www.bloodjournal.org/site/subscriptions/index.xhtml Blood (print ISSN 0006-4971, online ISSN 1528-0020), is published weekly by the American Society of Hematology, 2021 L St, NW, Suite 900, Washington DC 20036. Copyright 2011 by The American Society of Hematology; all rights reserved. From www.bloodjournal.org by guest on October 28, 2014. For personal use only. 23 OCTOBER 2014 x VOLUME 124, NUMBER 17 CONTENTS COVER FIGURE Prior to the appearance of polyploid megakaryocytes, the early embryo generates platelets from a population of diploid cells. This image shows proplatelets being generated in vitro after the culture of E10.5 yolk sac cells. See the article by Potts et al on page 2725. INSIDE BLOOD COMMENTARIES 2617 The fat and the skinny on acute lung injury James C. Zimring Comment on Ortiz-Muñoz et al, page 2625 2618 A novel treatment of anemia of inflammation Andrea U. Steinbicker Comment on van Eijk et al, page 2643 2619 MDS-related mutations in aplastic anemia Seishi Ogawa Comment on Kulasekararaj et al, page 2698 2620 Diploid, not polyploid: new platelet producers Eriko Nitta and Atsushi Iwama Comment on Potts et al, page 2725 2622 Stress-enhanced translation of g-globin mRNA Jane-Jane Chen Comment on Hahn and Lowrey, page 2730 2623 KIR B or not to be?...that is the question for ALL Michael R. Verneris and Jeffrey S. Miller Comment on Oevermann et al, page 2744 PLENARY PAPER 2625 Aspirin-triggered 15-epi-lipoxin A4 regulates neutrophil-platelet aggregation and attenuates acute lung injury in mice Guadalupe Ortiz-Muñoz, Beñat Mallavia, Adriaan Bins, Mark Headley, Matthew F. Krummel, and Mark R. Looney HOW I TREAT 2635 How I treat myelofibrosis Francisco Cervantes CLINICAL TRIALS AND OBSERVATIONS 2643 Brief Report Effect of the antihepcidin Spiegelmer lexaptepid on inflammation-induced decrease in serum iron in humans Lucas T. van Eijk, Aaron S. E. John, Frank Schwoebel, Luciana Summo, St´ephanie Vaul´eon, Stefan Z¨ollner, Coby M. Laarakkers, Matthijs Kox, Johannes G. van der Hoeven, Dorine W. Swinkels, Kai Riecke, and Peter Pickkers vii BLOOD, 23 OCTOBER 2014 x VOLUME 124, NUMBER 17 CONTINUED ON viii From www.bloodjournal.org by guest on October 28, 2014. For personal use only. HEMATOPOIESIS AND STEM CELLS 2647 Epigenetic control of dendritic cell development and fate determination of common myeloid progenitor by Mysm1 Haejung Won, Vijayalakshmi Nandakumar, Peter Yates, Suzi Sanchez, Lindsey Jones, Xue F. Huang, and Si-Yi Chen IMMUNOBIOLOGY 2657 Fine-mapping of HLA associations with chronic lymphocytic leukemia in US populations Loren Gragert, Stephanie Fingerson, Mark Albrecht, Martin Maiers, Matt Kalaycio, and Brian T. Hill 2666 Human T-follicular helper and T-follicular regulatory cell maintenance is independent of germinal centers Elizabeth F. Wallin, Elaine C. Jolly, Ondˇrej Such´anek, J. Andrew Bradley, Marion Esp´eli, David R. W. Jayne, Michelle A. Linterman, and Kenneth G. C. Smith LYMPHOID NEOPLASIA 2675 Pyk2 promotes tumor progression in multiple myeloma Yu Zhang, Michele Moschetta, Daisy Huynh, Yu-Tzu Tai, Yong Zhang, Wenjing Zhang, Yuji Mishima, Jennifer E. Ring, Winnie F. Tam, Qunli Xu, Patricia Maiso, Michaela Reagan, Ilyas Sahin, Antonio Sacco, Salomon Manier, Yosra Aljawai, Siobhan Glavey, Nikhil C. Munshi, Kenneth C. Anderson, Jonathan Pachter, Aldo M. Roccaro, and Irene M. Ghobrial 2687 A Bim-targeting strategy overcomes adaptive bortezomib resistance in myeloma through a novel link between autophagy and apoptosis Shuang Chen, Yu Zhang, Liang Zhou, Yun Leng, Hui Lin, Maciej Kmieciak, Xin-Yan Pei, Richard Jones, Robert Z. Orlowski, Yun Dai, and Steven Grant MYELOID NEOPLASIA 2698 Somatic mutations identify a subgroup of aplastic anemia patients who progress to myelodysplastic syndrome Austin G. Kulasekararaj, Jie Jiang, Alexander E. Smith, Azim M. Mohamedali, Syed Mian, Shreyans Gandhi, Joop Gaken, Barbara Czepulkowski, Judith C. W. Marsh, and Ghulam J. Mufti 2705 TET2 mutations predict response to hypomethylating agents in myelodysplastic syndrome patients Rafael Bejar, Allegra Lord, Kristen Stevenson, Michal Bar-Natan, Albert P´erez-Ladaga, Jacques Zaneveld, Hui Wang, Bennett Caughey, Petar Stojanov, Gad Getz, Guillermo Garcia-Manero, Hagop Kantarjian, Rui Chen, Richard M. Stone, Donna Neuberg, David P. Steensma, and Benjamin L. Ebert PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS 2713 Monocytic cell differentiation from band-stage neutrophils under inflammatory conditions via MKK6 activation Ren´e K¨offel, Anastasia Meshcheryakova, Joanna Warszawska, Annika Hennig, Karin Wagner, Almut J¨orgl, Daniela Gubi, Doris Moser, Anastasiya Hladik, Ulrike Hoffmann, Michael B. Fischer, Wim van den Berg, Marije Koenders, Clemens Scheinecker, Bernhard Gesslbauer, Sylvia Knapp, and Herbert Strobl PLATELETS AND THROMBOPOIESIS 2725 Brief Report A lineage of diploid platelet-forming cells precedes polyploid megakaryocyte formation in the mouse embryo Kathryn S. Potts, Tobias J. Sargeant, John F. Markham, Wei Shi, Christine Biben, Emma C. Josefsson, Lachlan W. Whitehead, Kelly L. Rogers, Anna Liakhovitskaia, Gordon K. Smyth, Benjamin T. Kile, Alexander Medvinsky, Warren S. Alexander, Douglas J. Hilton, and Samir Taoudi viii BLOOD, 23 OCTOBER 2014 x VOLUME 124, NUMBER 17 CONTINUED ON x From www.bloodjournal.org by guest on October 28, 2014. For personal use only. RED CELLS, IRON, AND ERYTHROPOIESIS 2730 Brief Report Induction of fetal hemoglobin through enhanced translation efficiency of g-globin mRNA Cynthia K. Hahn and Christopher H. Lowrey TRANSPLANTATION 2735 T-cell-replete haploidentical HSCT with low-dose anti-T-lymphocyte globulin compared with matched sibling HSCT and unrelated HSCT Yi Luo, Haowen Xiao, Xiaoyu Lai, Jimin Shi, Yamin Tan, Jingsong He, Wanzhuo Xie, Weiyan Zheng, Yuanyuan Zhu, Xiujin Ye, Xiaohong Yu, Zhen Cai, Maofang Lin, and He Huang 2744 Brief Report KIR B haplotype donors confer a reduced risk for relapse after haploidentical transplantation in children with ALL Lena Oevermann, Sebastian U. Michaelis, Markus Mezger, Peter Lang, Jacek Toporski, Alice Bertaina, Marco Zecca, Lorenzo Moretta, Franco Locatelli, and Rupert Handgretinger BLOOD WORK 2748 Digital imaging of peripheral blood identifies atypical chronic lymphocytic leukemia Steven Marionneaux and Larry Smith 2749 Caught in transformation Mina L. Xu and Dennis Cooper CORRESPONDENCE 2750 Heterozygous missense mutations in the GLRX5 gene cause sideroblastic anemia in a Chinese patient Gang Liu, Shanshan Guo, Gregory J. Anderson, Clara Camaschella, Bing Han, and Guangjun Nie 2752 Bortezomib is a rapid mobilizer of hematopoietic stem cells in mice via modulation of the VCAM-1/VLA-4 axis Armin Ghobadi, Michael P. Rettig, Matthew L. Cooper, Matthew S. Holt, Julie K. Ritchey, Linda Eissenberg, and John F. DiPersio OTHER DEPARTMENTS xxxi iib Author Guide Classifieds SUBMISSION INSTRUCTIONS All manuscripts, including figures, should be submitted electronically at http://submit.bloodjournal.org to Editor-in-Chief Bob L¨owenberg, MD, PhD. Before submitting your paper, review Blood’s Author Guide at http://bloodjournal.hematologylibrary.org/site/authors/ authorguide.xhtml. If you need help during the submission process, contact the Editorial Office by phone at 202-776-0548 or via e-mail at editorial@hematology.org. x BLOOD, 23 OCTOBER 2014 x VOLUME 124, NUMBER 17
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