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ALPAFLOR® LINUM AO
ALPAFLOR® linum ao
99.85% Natural Origin
24.33% Organic Origin
Raw material certified by Ecocert Greenlife according to the Ecocert Standard
for Natural and Organic Cosmetics available at http://cosmetics.ecocert.com
The Alpine irritation soothing solution
for natural cosmetics
ALPAFLOR® linum ao
5% Natural (96% Organic)
30% Water
65% Derived natural
0.15% Nature-identical
Complies with the NATRUE Criteria.
Exclusive N.A. Distributor
CENTERCHEM, INC. NORWALK, CT
Ph: 203-822-9800 Fax: 203-822-9820
www.centerchem.com
BOTANICS
Linen, which is made from flax, is the oldest textile material
in the world. Its history goes back to many thousand of
years. Fragments of straw, seeds, fibres, yarns and various
types of fabrics which date back to about 8000 before J.C.
have been found in Swiss lake dwellings. Linen was used in
the Mediterranean in the pre-Christian age. Linen was
sometimes used as currency in ancient Egypt. Egyptian
mummies were wrapped in linen because it was seen as a
symbol of light and purity, and as a display of wealth.
Currently most flax produced are seed flax types for the
production of linseed oil or flaxseeds for human nutrition as
well as for cosmetics.
Till now almost unknown for its soothing properties, the flax
flower presents a new interesting raw material for skin care
applications.
Linum alpinum is a flowering plant of the family Linaceae, native in the Alps. It is a
slender herbaceous perennial growing to 30 cm tall, with spirally arranged narrow
lanceolate leaves. The flowers are blue, 16-25 mm in diameter, with five petals. Found
in nature at altitudes till 1700m, Linum alpinum ‘s blooming period extends from May to
August.
Linum alpinum L. is cultivated in the Alps for the needs of ALPAFLOR®.
TRADITIONAL MEDICINE
Line seeds are rich in fats, proteins, fibres, fibrils and vitamins and can therefore be used for
the therapy of chronic obstructive disorders and as dietary supplement.
ORGANIC CULTIVATION certified by BIO.SUISSE
ALPAFLOR® has developed its own plant cultures in collaboration with Swiss alpine farmers
who have over 20 years of experience in this field. This production fits into the philosophy of
maintaining an economic activity profitable to mountain farmers, preserving natural sites and
rare plants, supporting the alpine biodiversity and retaining our alpine plant heritage.
The 100% organic culture methods used (no pesticides, mineral fertilizers or herbicides) are
guaranteed by the Bio-Swiss seal of approval.
From the seeds to the harvest…
ALPAFLOR® secures the traceability of the plants used.
1. Young culture of Linum alpinum in the Swiss
Alps
2. Second year of culture, before blooming
3. Blooming period of Linum alpinum in culture
4. Blooming period of Linum alpinum in culture
5. Blooming time
2. Flower of Linum alpinum
FUNCTIONS
Constituents of the extract
Functions
Flavonoids (Saponarin)
Anti-inflammatory, antioxidant, radical scavenger
Phenolic acids
Antioxidant, radical scavenger
Tannins
Antiseptic, antioxidant, astringent, anti-inflammatory
Lignans (podophyllotoxin)
Antimitotic, phytoestrogenic activity, antioxidant
REFERENCES
1.
Schmidt T.J. et al., “A combined HPLC-UV and HPLC-MS method for the identification of lignans
and its application to the lignans of Linum usitatissimum L. and L. bienne Mill.”, Phytochemical
Analysis, 2006, 17 (5) 299-311
2.
Tülay C. et al., “Free radical scavenging activity of linum arboretum”, Pharmaceutical Biology,
2005, 43 (4) 370-372
3.
Dubois J. and Mabry T.J., “The C-glycosylflavonoids of flax”, Phytochemistry, 1971, 10 (11) 28392840
EFFICACY
in vitro Tests
Induction of intercellular adhesion molecule 1 (ICAM-1) expression in the epidermis is felt to
be an important initiator of keratinocyte interactions in many inflammatory skin diseases.
Human keratinocytes during the course of inflammatory dermatoses strongly express the
surface molecule ICAM-1.
Accordingly, ICAM-1 expression is known to be induced in vivo and in vitro by cytokines
either via the TNF alpha/TNF beta or via the IFN gamma-mediated pathway.
The efficacy of ALPAFLOR® LINUM AO was demonstrated by an in vitro test measuring its
ICAM-1 expression reducing effect on human keratinocytes stimulated by Interferon-γ.
ICAM-1 Expression in human keratinocytes (%)
120
100
80
60
40
20
0
Control
Positive
control
ZnSO4
(50µM)
LINUM
AO (1
mg/ml)
LINUM
LINUM
AO (2.5
AO
mg/ml) (5mg/ml)
ALPAFLOR® LINUM AO has shown its capacity to reduce the inflammatation of
keratinocytes dose dependently:
by 11% at a concentration of 2.5 mg/ml;
by 31% at a concentration of 5mg/ml.
ALPAFLOR® LINUM AO reduces the skin inflammation reactions by decreasing the
production of ICAM-1.
ALPAFLOR® LINUM AO is especially intended for skin care products that target irritated or
sensitive skin.
PROPERTIES
-
Anti-inflammatory
Antioxidant
Calming
Soothing
COSMETIC APPLICATIONS
-
Day and night care products for sensitive and irritated skin
After sun formulations
Dry skin preparations
SUGGESTED CONCENTRATION
-
1-3 %
COMPOSITION INCI NAME
-
See Product Data Sheet
PRODUCT CODES
-
929-01 (Pentapharm)
-
50 3755 7 (DSM)
Beauty, purity,
authenticity and
efficacy…
for natural
formulations
Plant Extracts from the Swiss Alps
Copyright © 2010 DSM Nutritional Products AG, CH-4002 Basel, Switzerland. All rights reserved. No part of this brochure may be reproduced, distributed or translated in any form or by any means, or stored
in a database or retrieval system, without the prior written permission of DSM Nutritional Products AG (“DSM”). While making reasonable efforts to ensure that all information in this brochure is accurate and up
to date, DSM makes no representation or warranty of the accuracy, reliability, or completeness of the information. Use of this information shall be at your discretion and risk. Nothing herein relieves you from
carrying out your own suitability determinations and tests and from your obligation to comply with all applicable laws and regulations and to observe all third party rights. The uses and claims for DSM’s products
recommended in the brochure should be adapted to the current local regulatory environment. We disclaim any and all liability in connection with your product or its use.
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DSM Nutritional Products Ltd.
P.O. Box 2676, CH-4002 Basel, Switzerland
Phone: +41 61 815 88 88
Fax: +41 61 815 88 80
info.dnp@dsm.com
www.dsmnutritionalproducts.com