1. religion and spirituality
2. judaism

The:Mount:Sinai:
Postdoc:Periodical
Monthly:newsletter,:May:2015
In this issue:
Page 1:
Future:Leaders:for:Women:in:Research::Interview:with:
Dr.:Susmita:Sahoo,:PhD
;y)Delaine)Ceholski
Future:Leaders:for:Women:in:
Research::Interview:with:Dr':Susmita:
Sahoo:of:the:Cardiovascular:Research: This) monthK) we) were) fortunate) to) interview) Dr2) Susmita) SahooK) PhD) of) the) Cardiovascular) Research) Center)
WCVRC?)at)Mount)Sinai2)Dr2)Sahoo)is)a)newly)minted)assistant)professor)and)has)been)with)the)CVRC)for)less)
Center:at:Mount:Sinai
than)A)year2)In)this)interviewK)we)find)out)what)it’s)like)and)what)it)takes)to)obtain)an)academic)position)in)the)
current)academic)job)environment2
VD:vaccines::a:potential:cure:for:
A2)Where)did)you)do)your)PhD0
cancer?
Page 2:
Nonzinvasive:ultrasound:waves:as:a:
potential:treatment:for:Alzheimer3s
:
Upcoming:event:notices:and:the:
Postdoc:Executive:CozChair:Corner
I) received) my) PhD) from) the) Indian) Institute) of) TechnologyK) MumbaiK) IndiaK) in) ;iotechnology) and)
;ioengineering2)My)mentors)were)Drs2)G2K2)Suraishkumar)and)K2K2)Rao2)I)am)grateful)to)them)for)nurturing)
the)creativity)required)to)generate)scientific)ideasK)fostering)my)independence)and)inculcating)the)importance)
of)communication)skills)early)in)my)career2)
Page 3:
L2)Where)and)with)who)did)you)do)your)postdoc)and)for)how)long0
Ebola:Survivor:Discovers:Virus:in:Eye
Interview:with:Nikos:TzavarasA:
member:of:the:Sinai:Consulting:Club
Page 4:
Periodical:Word:Search::SpringI
My)postdoctoral)training)was)rather)unconventional2)Upon)obtaining)my)degreeK)I)joined)a)small)biotech)start)
upK) ;ioElectroMed) Corporation2) !fter) working) for) the) company) for) about) a) yearK) I) left) and) joined) the)
laboratory) of) Dr2) Efrat) Levy) at) the) Nathan) Kline) InstituteK) OrangeburgK) NY2) I) learned) to) integrate) basic)
mechanisms)of)cellular)biology)into)a)complex)disease)milieu2)!fter)about)three)yearsK)I)secured)a)position)
working) with) Dr2) Douglas) Losordo’s) team2) He) is) an) internationally) recognized) cardiologist) and) a) physician)
scientist) and) a) proponent) of) stem) cell) therapy) for) ischemic) cardiovascular) diseases2) This) was) my) final)
postdoc)trainingK)which)lasted)for)L)years2)
N2)Why)did)you)want)to)become)a)PI)in)an)academic)institution0)Why)did)you)choose)it)over)a)nonqacademic)career0)
While) working) for) ;ioElectroMed) CorporationK) I) came) to) realize) my) true) passion) q) to) pursue) an) independent) academic) research) career2) In) an)
academic)institutionK)I)am)able)to)be)independent)and)nurture)my)scientific)curiosityK)which)provides)me)with)an)enormous)amount)of)professional)
satisfaction2) In) additionK) my) personality) traits) for) career) success) lie) in) an) environment) where) I) can) formulate) my) own) projects) and) enjoy) a)
collaborative)setting2
O2)What)was)the)most)difficult)obstacle)that)you)faced)during)your)search)for)a)position0
In)the)final)years)of)my)postdoc)careerK)I)focused)on)building)a)research)identity)separate)from)my)mentors2)I)began)to)study)the)role)of)miniature)
vesicles)called)exosomes)secreted)from)stem)cells)in)cardiac)regeneration2)This)field)of)study)was)newly)emerging)and)a)somewhat)risky)move)for)
me)because)institutes)tend)to)recruit)new)faculty)whose)research)aligns)with)and)complements)their)existing)programs2
Y2)In)your)opinionK)what)is)the)largest)contributing)factor)to)becoming)a)PI0)
I) cannot) attribute) my) success) in) becoming) a) PI) to) one) factor) but) a) convergence) of) many2) I) found) a) great) postdoc) mentor) in) Dr2) Losordo2) His)
laboratory) was) an) excellent) environment) where) I) witnessed) and) benefitted) from) his) handsqon) approach) to) leading) an) extensive) team) of)
researchersK)techniciansK)and)collaborators2)I)was)also)in)the)company)of)many)hardworking)and)successful)postdocs)who)went)on)to)become)PIsK)
which)instilled)positivityK)patience)and)confidence)in)me2)I)learned)the)importance)of)communicationUpublic)speaking)skills2);efore)we)presented)at)
scientific) conferencesK) trainees) had) to) give) at) least) three) seminars) where) everyone) was) encouraged) to) critique) the) presentation2) I) learned) the)
importance)of)networking)with)peers)and)established)scientists)at)scientific)meetings)who)can)provide)insightK)advice)and)even)job)opportunities2)
MoreoverK)I)looked)for)help)in)grant)writing)and)attended)an)excellent)workshop)led)by)Dr2)Richard)McGee)at)Northwestern)where)applications)are)
vigorously) reviewed2)I)was) fortunate) to)be)successful) in)my) early) grant) applications) and)started) my) own) small) independent) laboratory)with) one)
technician) after) my) postdoc) training) with) Dr2) Losordo2) !t) the) beginning) it) was) a) challenge) to) balance) the) various) aspects) of) managing) a) lab-)
financesK)protocol)approvalsK)training)junior)personnelK)grant)writing)and)research)compliances)issuesK)etc2)!s)daunting)as)it)wasK)I)am)glad)I)had)
the)opportunity)to)learn2)I)truly)believe)that)all)of)my)efforts)contributed)to)the)success)of)my)first)REA)application)to)the)NIH2)
x2)What)advice)can)you)give)to)those)postdocs)who)want)to)pursue)an)academic)career0)Is)there)anything)
that)you)would)have)done)differently)given)your)experience0
I)cannot)underscore)the)importance)of)publishingK)developing)your)own)identityK)establishing)your)
own)networkK)marketing)your)research)and)creating)a)good)support)system2)Identify)and)address)
your)weaknesses)and)build)your)own)niche)q)be)uniqueM)This)is)not)easyq)you)have)to)take)more)
responsibilities) outside) of) research) which) are) time) consuming2) ;ut) those) come) with) a) good)
reward4)any)additional)thing)that)you)do)will)teach)something)new)and)can)expand)your)network2)
SometimesK) there) will) be) setbacksq) but) try) to) use) it) to) feed) your) motivation2) I) always) welcome)
criticism) and) strive) for) excellence2) These) attributes) worked) well) with) my) immigrant) background)
where) I) had) to) merge) into) a) new) societyK) find) a) balance) between) scientific) excellence) and)
employability)and)draw)strength)from)my)failures2)!nother)key)is)to)start)early)Wafter)your)terminal)
degree?) to) apply) for) postdoc) grant) applications) and) later) for) fellowqtoqfaculty) transition) awards2)
Engage) your) mentorUteam) of) mentors) actively) to) develop) a) comprehensive) career) development)
plan) with) specific) shortq) and) longqterm) goals) in) mind2) !ttend) the) early) career) programs) in)
professional) conferences) to) understand) the) basic) peerqreview) processK) grantsmanshipK) career)
opportunities)etc2);elieve)in)your)unique)abilities)and)don’t)be)afraid)to)take)the)unexpected)path2)
Do)the)extra)work)to)build)your)own)package2)It)may)not)be)easyK)but)success)will)come2
The:Mount:Sinai:Postdoc:PeriodicalA:May:bEx!
Dr2)Susmita)SahooK)PhD
Page:x
3D vaccines: a potential cure for cancer?
zyvKatievNolanv
Co-Chair Corner
zyv”rsxvMerinavVarghesevandvRyanv“ummings
Newv advancesv inv cancerv therapyv arev focusingv onv usingv j”v vaccinesv tov
harnessvthevbody’svnaturalvimmunevsystemvtovkillvcancervcellsxvUvresearchv
groupv ledv byv ”rxv ”avidv Mooneyv fromv thev Schoolv ofv qngineeringv andv
Uppliedv Sciencesv atv ?arvardv Universityv hasv recentlyv usedv thisv novelv
vaccinev tov delayv tumorv growthv inv micexv “ancerv cellsv developv fromv thev
body’sv ownv naturalv cellsv duev tov mutationsv andv increasedv proliferativev
ability(vwhichvenablesvtumorvformationxvSincevthevcancervcellsvarevnativev
tovthevbodyvtheyvcanvevadevthevnaturalvimmunevresponsevwhichvremovesv
foreignvinvadersvandvcontrolsvcellvdeathxv
Recentvclinicalvstudiesvhavevfocusedvonvimmunotherapies(vwhichvusevthev
bodies’v ownv immunev systemv tov fightv thev cancerxv Previousv workv inv thisv
areav hasv utilizedv whitev bloodv cellsv fromv av patient’sv bloodxv Thesev whitev
bloodv cellsv arev “programmed”v intov dendriticv cells(v whichv arev capablev ofv
identifyingvandvtargetingvpathogensvandvcanvrecognizevandvattackvcancerv
cellsxv Thev successesv inv thisv areav havev demonstratedv thev potentialv forv
immunotherapiesv butv theyv havev notv yetv achievedv lastingv therapeuticv
effectxv
”rxv Mooney’sv labv hasv developedv anv injectablev “self)assembly”v scaffoldv
composedv ofv mesoporousv silicav rodsv 1MSRs0xv Thesev MSRsv
spontaneouslyvassemblevinvvivovtovformvavporousvstructurevwhich(vthroughv
biochemicalv cues(v canv attractv hostv immunev cellsv andv illicitv av targetedv
immunevresponsexvThesevbio)scaffoldsvhavevnumerousvapplicationsvinvthev
fieldsvofvtargetedvdrugvreleasevandvregenerativevmedicinexvUnothervbenefitv
ofv thisv approachv isv thatv thev MSRs’v self)assemblyv meansv patientsv wouldv
notv requirev implantationv surgeryv andv therev wouldv bev minimalv woundv
damagexv Previousv workv inv thev Mooneyv labv identifiedv thatv scaffoldv
implantationvcouldvincreasevsurvivalvbyv89!vinvmicevwhovwouldvotherwisev
diev fromv cancerv atv j9v daysxv v Thev latestv studyv foundv thatv injectionv ofv thev
j”v vaccinev wasv morev effectivev atv preventingv tumorv growthv andv therebyv
affectingvsurvivalvwhenvcomparedvtovavbolusvcontrolxv
”rxv Mooneyv isv hopefulv thatv thisv
technologyv willv gov beyondv cancerv
treatmentsv andv willv findv applicationsv
inv treatingv andv preventingv infectiousv
diseasesxv Wantv morev informationEv
“heckvoutvwwwxnibibxnihxgovxv
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postdoctoralv fellowsv 1httpAJJwwwxnationalpostdocxorgJpublications)@J
competencies0xv zesidesv fundingv yourv project(v thev processv ofv grantv
writingv alsov helpsv tov distillv yourv researchv ideasv andv honev yourv writtenv
presentationv ofv sciencev tov convincev anv audiencev outsidev yourv labxv Ifv
youvhavevnotvappliedvforvyourvownvgrantvyet(vherevarevsomevresourcesv
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Thev Officev ofv Postdoctoralv Uffairsv maintainsv av listv ofv grantsv andv
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Ifv youv arev interestedv inv tryingv outv somethingv otherv thanv conventionalv
fundraisingv approaches(v Mountv Sinaiv recentlyv announcedv supportv forv
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Postdoctoralv Uffairsv alsov issuesv postdocv recognitionv awardsv forv grant)
winningv postdoctoralv fellowsv andv anv annualv fellowshipv forv seniorv
womenv postdoctoralv fellowsv 1httpAJJicahnxmssmxeduJeducationJ
postdoctoral)trainingJannouncementsJbulletin)board0xv
Thev nextv monthlyv Postdocv Socialv willv bev onv Mayv b8th(v @)4v pmv inv thev
Icahnv M“v levelxv Thev Postdocv qxecutivev “ommitteev 1Pq“0v isv alsov
planningvanvUlumnivSocial(vwherevyouvcanvmeetvandvminglevwithvformerv
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yourvemailvinboxvorvjoinvourvsocialvmediavpagesvforvupdatesvonvthisx
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Ryanv“ummingsvandvMerinavVarghesevarevyourvPq“vco)chairsx
Non-invasive ultrasound waves as a
potential treatment for Alzheimer’s Disease
byv”elainev“eholski
Ulzheimer’sv diseasev isv av neurodegenerativev disorderv characterizedv byv
progressivev cognitivev impairmentv andv memoryv lossxv Thev diseasev isv
characterizedvbyvlossvofvbrainvtissuevandvformationvofvplaquesvconsistingvofv
deadv cellsv andv amyloid)betav 1Uβ0v proteinxv Microgliav arev residentv
macrophagesv ofv thev brainv andv spinalv cordv andv functionv tov eliminatev
proteinsv suchv asv Uβxv ?owever(v inv Ulzheimer’sv diseasev thev microgliav arev
impairedxvThevQӧtzvgroupvfromvthevQueenslandvzrainvInstitutevinvUustraliav
hasv adaptedv av “anadian)developedv techniquev ofv usingv ultrasoundv wavesv
andv microbubblesv tov openv thev blood)brainv barrier(v providingv transientv
openingsvforvimmunevsystemvcomponentsvtovgetvthroughxvzyvopeningvthev
blood)brainv barrierv andv allowingv componentsv ofv thev immunev systemv
through(vthevultrasoundvtreatmentvcouldvre)activatevmicrogliaxv
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resultedvinvactivationvofvmicroglia(v4@!v
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reductionv inv plaques(v andv av
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multiplev memoryv testsv 1seev originalv
•//Join/our/LinkedIn/group:/“Mount Sinai Postdoctoral Association”
articlev
publishedv
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Sciencev
TranslationalvMedicine0xvWhilevthisv
The Mount Sinai Postdoc Periodical
treatmentv isv non)invasive(v thev implicationsv ofv evenv transientlyv openingvthev
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blood)brainv barrierv inv humansv arev unknownv andv thev Uustralianv groupv isv
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The/Mount/Sinai/Postdoc/PeriodicalC/May/2015
Page/2
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The Mount Sinai Postdoc Periodical, May 2015
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