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Yuqian Shi
220 Mt Evans Dr, Durham, NC 27705
Phone: (919) 381-2399
E-mail: ys89@duke.edu
EDUCATION
Sep 2011 – present
Duke University, Durham, NC
PhD candidate in Biochemistry
Areas of Interest: Human DNA Repair and Drug Design
Current GPA: 3.93
Sep 2007 – Aug 2011
The Hong Kong University of Science and Technology (HKUST), Hong Kong
First Class Honors Bachelor of Science in Biochemistry
Minors: Biotechnology, Biology and Mathematics
Areas of Interest: Immune System Development and Regulation
Sep 2004 – Jun 2007
Beijing Huiwen High School (Peking Academy), Beijing, China
China College Entrance Exam Score: 654/750 (Top 0.1%)
PUBLICATIONS
Shi, Y., Mao, L., Kumar, S., Beese, L. (2014). The complex structure of human exonuclease 1 C-terminal region
with PCNA reveals a new PIP-box interaction conformation. (paper in preparation)
Mabanglo, M., Shi, Y., Hast, M., Lubock, N., Beese, L. (2014). 3-D structure and steady-state kinetics of Candida
albicans protein farnesyltransferase reveal strategies for designing dual prenyltransferase inhibitors with
fungal enzyme selectivity. (paper in preparation)
Li, L., Yan, B., Shi, Y., Zhang, W., Wen, Z. (2012). Live imaging reveals differing roles of macrophages and
neutrophils
during
zebrafish
tail
fin
regeneration.
J
Bio
Chem,
287(30):
25353-60.
doi:
10.1074/jbc.M112.34912
Li, L., Jin, H., Xu, J., Shi, Y., Wen, Z. (2011). Irf8 regulates macrophage versus neutrophil fate during zebrafish
primitive myelopoiesis. Blood, 117(4):1359-69
TALKS, PRESENTATIONS, POSTERS, and PROCEEDINGS
Shi, Y. (2014). Molecular Mechanism of Human Exonuclease 1. Talk at Duke Biochemistry Retreat 2014,
Wilmington, NC.
Shi, Y., McSweeny, E., Beese, L. (2014). Structural Investigation of Human Exonuclease 1. Duke Biochemistry
Retreat 2014 Wilmington, NC.
Mao, L., Shi, Y., Wu, Q., Zhou, P., Beese, L. (2014). Biochemical and Biophysical Characterization of Human
Exonuclease 1 Regulatory C-terminal Domain. Duke Biochemistry Retreat 2014, Wilmington, NC.
Shi, Y., McSweeny, E., Mao, L., Beese, L. (2014). Structural Invesstigation of Human Exonuclease 1 (hExo1). 44th
Mid-Atlantic Macromolecular Crystallography Meeting (MAMCM) and 11th SER-CAT Symposium, Maryland,
MA.
Shi, Y., McSweeny, E., Mao, L., Beese, L. (2014). Structural Invesstigation of Human Exonuclease 1 (hExo1).
Duke Biochemistry Symposium 2014, Durham, NC.
Mao, L., Shi, Y., McSweeny, E., Beese, L. (2014). Mapping Mismatch Repair Protein Interactions to the
Regulatory C-terminal Tail of Human Exonuclease 1. Duke Biochemistry Symposium 2014, Durham, NC.
Shi, Y., McSweeny, E., Mao, L., Kumar, S., Beese, L. (2014). Characterization of Human Exonuclease 1(hExo1)
C-terminal Protein-protein Interactions. 13th The Structural Cell Biology of DNA Repair Machines Meeting
(SBDR), Berkeley, CA.
McSweeny, E., Shi, Y., Beese, L. (2013). Ensemble of Human Exonuclease 1 Complexes with DNA Provides
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Yuqian Shi
220 Mt Evans Dr, Durham, NC 27705
Phone: (919) 381-2399
E-mail: ys89@duke.edu
Novel Insights into Mechanism. 43th Mid-Atlantic Macromolecular Crystallography Meeting (MAMCM),
Durham, NC.
Shi, Y., McSweeny, E., Beese, L. (2012). Structure Analysis of Human Exonuclease 1 R92A Mutant Complexes.
Duke Biochemistry Retreat 2012, Wilmington, NC.
Shi, Y. (2011). The Certification of Coronin 1a Transgenic Zebrafish. HKUST UROP Proceedings 2010, 7.
Shi, Y. (2010). The Effect of Pu.1 or/and Runx1 Mutation on Zebrafish Primitive Hematopoiesis. HKUST UROP
Proceedings 2009, 6.
GRANTS, HONORS and AWARDS
2014
Cover Image, 2014 Duke Biochemistry Retreat, Wilmington, NC.
2014
Design Award, Duke Biochemistry Tee design Contest, Durham, NC
2014
Best Poster Presentation Award (HKL Award, 2%), 44th Mid-Atlantic Macromolecular
Crystallography Meeting (MAMCM) and 11th SER-CAT Symposium, Maryland, MA.
2010 – 2011
HKUST Scholarship for UG Students, reorganization and honor for students with outstanding
academic performance.
2009 – 2010
HKUST Undergraduate Research Opportunities Program Grant (twice), HKUST, Hong Kong
2008 – 2010
Dean’s List (Continuous 4 times), HKUST honor for outstanding students
RESEARCH EXPERIENCES
2012 – present
Lorena Beese Laboratory, Duke University Medical Center, Durham, NC
Graduate Research Assistant
-
Investigation of molecular mechanisms of human DNA mismatch repair (MMR)
proteins using Structural and Biochemical approaches.
2009 – 2011
in silico and in vitro drug design for fungi farnesyltransferase.
State Key Developmental Biology Laboratory of Zilong Wen, HKUST, Hong Kong
Research Assistant
2007 – 2008
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Generated specifically labeled zebrafish transgenic lines.
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Studied macrophage and neutrophil development and behavior.
Costal Marine Biology Laboratory of Peiyuan Qian, HKUST, Hong Kong
Student Helper Leader
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Designed and improved microbial fuel cells.
-
Coordinate eight other student helpers in the lab.
TEACHING EXPERIENCES
2012
BIOCHEM 301- Introduction to Biochemistry I, Duke University, Durham, NC
Teaching Assistant
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One of the four teaching assistants on this class with more than 300 students.
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Preparing tutorials and TA sessions with other teaching assistants.
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Yuqian Shi
220 Mt Evans Dr, Durham, NC 27705
Phone: (919) 381-2399
E-mail: ys89@duke.edu
LEADERSHIP and TEAM EXPERIENCES
2013 – present
American Area Manager, Shanghai Tanxin Trading Co.,Ltd, Shanghai, China
(The largest longbow manufacturer in China)
2011 – present
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Lead and coordinate sales in North America.
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Communicate with Chinese manufacturer about company strategy.
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Design and manage online shops.
Senior Saints, Duke Christian on Campus, Durham, NC
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Lead and coordinated the local church development with other saints, the number of
active saints increased from less than ten to over forty.
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Designed and organized series of gospel activities on campus and in neighborhood, got
over two hundred people baptized
2008 – 2011
Communicated and visited more than ten churches in the USA with other saints.
Internal Secretary, Students’ Karate Club, HKUST, Hong Kong
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In charge of daily management of club internal affairs including training, membership
and dojo maintenance.
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Coordinated on-campus activities with other secretaries including competition,
promotion and performance.
2008 – 2009
Promotion Secretary, Film Society, HKUST, Hong Kong
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Directed and organized series of promotional activities with other committee members,
recruited more than 150 members.
2008
Designed and prepared stands, panels, posters, booklets for these activities.
Organizer, Peer-Counselor Program, HKUST, Hong Kong
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Coordinated with 12 junior undergraduate students and arranged activates to help them
get adjusted to college life.
2007 – 2008
Art Editor, The Sishuiliunian Magazine, Hong Kong
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Prepared layout of pages and picked necessary graphics and photographs to assist
stories.
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Coordinated with journalists and editorial staff and discussed ideas to be incorporated in
magazines.
2007
Established a style for publications and ensured compliance in every issue.
Interpreters, JIE Holding Group, Hangzhou,
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Translate for five foreign engineers.
COMPUTER SKILLS
Coding:
Python, Wolfram Mathematica, Matlab, HTML, CSS, PHP
Editing and Art:
Microsoft Office, Adobe Photoshop, Adobe Illustrator, Adobe InDesign, Adobe
Dreamweaver, Adobe Fireworks
Analysis:
JMP, Origin, Graphpad Prism, Kaleidagraph, ImageJ
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Yuqian Shi
220 Mt Evans Dr, Durham, NC 27705
Phone: (919) 381-2399
E-mail: ys89@duke.edu
Biological and Chemical:
Schrödinger Suite, PHENIX Suite, DNASTAR Lasergene Suite, CCP4 Suite, XDS, CNS
Suite, ChemBioOffice Suite, PyMOL, Chimera, Coot, KiNG, Scatter, Scaffold, Autodock,
iMosflm, HKL, etc
LANGUAGES
English: Proficient
Chinese: Native
Cantonese: Fluent, level 1 certificate
Japanese: Speak, read and write with basic competence
MEMBERSHIPS
America Mensa Member
Hong Kong Mensa Member, SIG Xuanzhuo
Hong Kong St. John Ambulance
ACTIVITIES
Member of North Carolina Bowhunter Association, BABINC certified, BCRS certified Bowhunter
Member of HKUST Karate Team, 2nd runner-up of Hong Kong Karate University Cup
Member of HKUST Judo Team
Member of HKUST Kendo Team
Member of HKUST Climbing Team
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