1. technology and computing

4-5 December 2014, London, UK
www.globalengage.co.uk/digital-pathology.html
Digital Pathology Congress
UNDERSTANDING & UTILIZING DIGITAL PATHOLOGY AS A TOOL FOR ADVANCING PATHOLOGY PRACTICE & ENABLING ENHANCED PATIENT CARE
Global Engage is pleased to announce their inaugural Digital Pathology Congress which will be held on December 4-5 in London, UK. The conference is part
of their successful Drug Discovery series which includes events on precision medicine, orphan drugs, synthetic biology, the human microbiome and digital PCR.
The continuing growth and advances in digital pathology solutions is transforming the industry. With wide ranging applications and benefits including
reduction in lab costs, increased workflow efficiency, greater interconnectivity, effective training / education methods, improved decision making is enabling
enhanced patient care. The result is that Digital Pathology is rapidly gaining momentum worldwide.
Attracting over 200 industry & academic experts working in all areas of Pathology this two day interactive meeting will provide the opportunity to take home
cutting edge strategies, analysis techniques, case study examples and methods to allow you to fully understand both the technology and accompanying
informatics and image analysis tools and utilize digital pathology to its greatest potential.
This will be achieved through a vibrant exhibition room full of technology providers showcasing their technologies and other solutions, networking breaks
allowing interaction with your peers, poster presentation sessions, expert led case study presentations and incisive Q&A panel discussions during three
separate tracks which will examine the topics below.
Confirmed Speakers Include:
Jo Martin
Liron Pantanowitz
Marcial Garcia Rojo
National Clinical Director of
Pathology NHS England,
Professor, Queen Mary
University of London, Director of
Academic Health Sciences, Barts
Health NHS Trust
Associate Professor of Pathology
& Biomedical Informatics, Director
of the Pathology Informatics
Fellowship Program
University of Pittsburgh Medical
Center
Head of Pathology Department.
Hospital de Jerez de la
Frontera, Cádiz, Spain
Conference Synopsis
Digital Pathology - Strategy and Technology

Introduction, benefits & future developments of Digital
Pathology

Implications on pathology practice
o
Uses in education and training

Converting to/ integration of digital pathology

Technology advances in digital pathology

Digital Pathology project updates

Standardisation in Digital Pathology

Quality control and improvement

Validation

Panel Discussion – Overcoming barriers in adoption of Digital
pathology
Digital Image Analysis

Overcoming challenges in image analysis
o Image standardization
o Compression techniques

Analysis software

Automated image analysis

Quantitative image analysis research

Visualization methods for diagnosis and prognosis

Annotation tools

Pattern recognition

Scoring

Algorithm development / Image analysis algorithms
Pathology Informatics

Acquisition, processing, archiving & retrieval of WSI

Cloud Computing

Access through mobile devices

Pathology PACS

Automation

Improving WSI workflow efficiency

Telepathology
o Virtual networks
o Use in remote areas

Telediagnosis

Pathology IT
Digital Pathology Applications and Research Case Studies
Research case studies utilizing digital pathology in

Clinical trials

Diagnosis

Diagnostics

Next generation sequencing

Biomarker analysis /research / quantification

Tissue-based research / imaging

Biobanking

Precision / personalised medicine

Image analysis
For more information please contact Steve Hambrook, Conference Director, Global Engage Ltd.
steve@globalengage.co.uk
+44 (0) 1865 849841
Digital Pathology Congress – 4-5 December 2014, London, UK
Confirmed Speakers
Paul van Diest, Head of
Department, Professor in
Pathology, University Medical
Center Utrecht, Netherlands
Johan Lundin, Research
Director and Professor of
Medical Technology, Institute
for Molecular Medicine Finland
(FIMM), Helsinki, Finland and
Karolinska Institute, Sweden
Yukako Yagi, Director of
Pathology Imaging and
Communication Technology
Center, Massachusetts
General Hospital and Harvard
Medical School, USA
Arvydas Laurinavičius, Director
National Pathology Center,
Vilnius University Hospital
Santariskes Clinics, Lithuania
Gloria Bueno, Professor, VISILAB –
School of Engineering, Universidad
de Castilla-La Mancha, Spain
Will Howat, Head of
Histopathology/ISH, Cancer
Research UK
Niels Grabe, Head, Hamamatsu
Tissue Imaging and Analysis
Center, Heidelberg University,
Germany
Marielle Odin, Director of
Pathology, Roche, Germany
Friedrich Feuerhake,
Neuropathologist, Institute of
Pathology, Hannover Medical
School, Germany
Toby Cornish, Assistant
Professor of Pathology,
Division of Gastrointestinal
and Liver Pathology, Johns
Hopkins School of Medicine,
USA
Mogens Vyberg, Professor of
Clinical Pathology, University
of Aalborg, Denmark
Jeroen van der Laak,
Assistant Professor in Digital
Pathology, Dept of Pathology,
Radboud University Nijmegen
Medical Centre, The
Netherlands
Eric Verbeeken, Professor, The
Translational Cell and Tissue
Research Group, KU Leuven,
Belgium
Janina Slodkowska,
Department of Pathology,
Consultant Specialist,
Military Institute of Medicine,
Poland
Kate Lillard, Chief Scientific
Officer, Indica Labs Inc.
Peter Hamilton, Professor,
Head of Bioimaging and
Informatics Research Group,
Queens University Belfast
Bruce Tanchel, Consultant
Histopathologist, Heart of
England NHS Foundation
Trust, UK
Peter Hufnagl, Head Digital
Pathology & IT, Institute of
Pathology, Charité University
Hospital Berlin, Germany
David Snead, Consultant
Histopathologist and Clinical
Service Lead, Coventry and
Warwickshire Pathology
Services, UK
Jorma Isola, Professor of Cancer
Biology, University of Tampere,
BioMediTech, Finland
Daniel Racoceanu,
Professor, Sorbonne
Universités, Université Pierre et
Marie Curie (UPMC) & Adjunct
Professor, National University
of Singapore (NUS)
Michael den Bakker, Consultant
Histopathologist Department of
Pathology, Maasstad Hospital, The
Netherlands
Keith Kaplan, Pathologist,
Charlotte, NC, USA
Sanja Stifter, Associate Professor,
Department of Pathology, Faculty
of Medicine, University of Rijeka,
Croatia
Rob Goldin, Professor of Liver
& GI Pathology, Faculty of
Medicine, Department of
Medicine, Imperial College
London, UK
Sebastian Brandner, Professor and
Chair of Neuropathology, Division
of Neuropathology, The National
Hospital for Neurology and
Neurosurgery, and Dept. of
Neurodegenerative Disease, UCL
Institute of Neurology, UK
Stephen Schmechel, Associate
Professor, Chief of Pathology
(Acting), Harborview Medical
Center, Department of
Pathology, University of
Washington School of
Medicine, USA
Olga Colgan, Director of
Commercial Marketing,
Aperio ePathology, Leica
Biosystems, Dublin, Ireland
Alison Bigley, Associate Principal
Scientist, Investigative &
Translational Pathology,
AstraZeneca, UK
Han van Krieken, Full Professor,
Pathology, Radboud University
Medical Center
Venue
London Heathrow Marriott Hotel
Bath Road
Hayes, UB3 5AN
United Kingdom
A discounted group rate is available to all
attendees. Details of how to book are
available on registration. Space is limited
and accommodation is available on a first
come basis.
For more information please contact Steve Hambrook, Conference Director, Global Engage Ltd.
steve@globalengage.co.uk
+44 (0) 1865 849841
Digital Pathology Congress – 4-5 December 2014, London, UK
Gold Sponsors
Silver Sponsors
Sponsors
Supporters
For more information please contact Steve Hambrook, Conference Director, Global Engage Ltd.
steve@globalengage.co.uk
+44 (0) 1865 849841
Agenda: Day One
Thursday, 4th December 2014
08.00-08.50
Registration & Coffee
08.50-09.00
Global Engage Welcome Address – County Hall Suite
09.00-09.30 Keynote Address - Title to be Confirmed
CONFIRMED:
Jo Martin, National Clinical Director of Pathology NHS England, Professor of Pathology, Queen Mary University of London, Director of
Academic Health Sciences, Barts Health NHS Trust
09.30-10.00 Keynote Address
Pros & Cons of Digital Pathology
Digital imaging has gained much traction in pathology globally. This keynote address will discuss:

The benefits of digital imaging and how these have been leveraged in the field of pathology.

The challenges that have to be overcome to see more widespread adoption of digital pathology.

Recent advances in technology and highlight future trends in digital pathology.
CONFIRMED:
Liron Pantanowitz, Associate Professor of Pathology & Biomedical Informatics, Director of the Pathology Informatics Fellowship
Program and Associate Director of the Pathology Informatics Division at the University of Pittsburgh Medical Center, USA
10.00-10.30 Solution Provider Presentation
Digital Pathology the Heart of the Lab, The Birmingham Heartlands Experience

Our experience at Birmingham Heartlands Hospital in trying to implement Digital Pathology into a real NHS Trust

I will discuss the challenges and difficulties we have faced and the successes we have had, including some unexpected ones

I will discuss how I see the future of Digital Pathology in the NHS
Bruce Tanchel, Consultant Histopathologist, Heart of England NHS Foundation Trust, UK
Sponsored by
10.30-11.40
Morning Refreshments & Poster Presentation Sessions
One-to-One Meetings
Digital Pathology Application and Research Case Studies
Pathology Informatics
County Hall Suite
Marble Arch Room
11.40-12.05 Digital Pathology And Tissue - Based Diagnosis. How do they
Semantics at the Helm and Scalability in Wholes Slide Image
Differ?
Exploration. How this could be Helpful for Big Data in HighContent Microscopy?
Semantics and imaging scalability are key issues in high-content
microscopy. After presenting an overview of massive data challenges
already knocking at the door of microscopy, we briefly present some
of our results on the path of highly efficient and scalable analysis of
massive whole slide images.
CONFIRMED:
Peter Hufnagl, Head Digital Pathology & IT, Institute of Pathology,
Charité University Hospital Berlin, Germany
12.05-12.30 Digital Pathology: Applications from Research to Clinical Trials
CONFIRMED:
Niels Grabe, Head, Hamamatsu Tissue Imaging and Analysis
Center, Heidelberg University, Germany
12.30-13.00 Solution Provider Presentation
Big Data – Short Learning Curve: A New Paradigm in Digital
Pathology Image Analysis. It’s about time – go from digital slide
to image analysis results faster with HALO and HyperCluster
technology
CONFIRMED:
Kate Lillard, Chief Scientific Officer, Indica Labs Inc.
CONFIRMED:
Daniel Racoceanu, Professor, Sorbonne Universités, Université
Pierre et Marie Curie (UPMC), France & Adjunct Professor,
National University of Singapore (NUS)
Development of Image Quality Assessment and Color
Standardization System for WSI
Or
Histology 3D Imaging /Multimodality 3D Imaging

To use WSI in Research and Clinical Diagnostic purpose, the
“accuracy” of image data (color and quality) is very
important.

Easy evaluation methods of appropriate image quality and
Color Standardization are necessary

Latest version of Color Standardization System and Image
Quality Assessment System will be introduced.
CONFIRMED:
Yukako Yagi, Director of the MGH Pathology Imaging &
Communication Technology (PICT) Center
Massachusetts General Hospital; Affiliated Faculty, Wellman
Center for Photomedicine, Massachusetts General Hospital;
Assistant Professor of Pathology, Harvard Medical School, USA
Solution Provider Presentation
For sponsorship opportunities please contact Steve Hambrook
at steve@globalengage.co.uk
For more information please contact Steve Hambrook, Conference Director, Global Engage Ltd.
steve@globalengage.co.uk
+44 (0) 1865 849841
Day One (cont.) – Thursday, 4th December
13.00-14.00
14.00-14.25
14.25-14.50
14.50-15.15
Lunch
One-to-One Meetings
Digital Immunohistochemistry for Tissue-Based Diagnosis and
Probing the Tumor Microenvironment with Cloud-Based Computer
Research: What Could and Should Be Done?
Vision
Digital pathology brings a quantification and capacity boost to tissue- Recent studies show a remarkable genomic diversity of cancerous
based biomarker testing as well as new quality of the information that tumors and indicate that various trajectories of genetic changes can
can be retrieved by computer vision. Most immediate benefits may be lead to the common phenotypic hallmarks of cancer. In fact, cancer
expected from digital immunohistochemistry - enabling better
might be a disease of microenvironmental opportunity. Our research
quantification, reproducibility, and new approaches to study spatial
vision is to explore the tumor microenvironment by a series of groundaspects of biomarker expression. To get there, one first needs to
breaking quantitative and descriptive tissue characterization methods.
develop methodologies to control accuracy of the testing, integrate
The methods include probing of whole-slide digitized tissue samples
and automate data management workflow.
with cloud-based computer vision and multiplexed readout of
molecular profiles - all aimed at capturing the biologically relevant
information in a spatial context. Computerized tissue morphological
analysis and tissue niche-specific molecular profiles are then combined
with clinical data for the purpose of a more precise prediction of
disease outcome, particularly in cancer.
CONFIRMED:
Arvydas Laurinavičius, Director, National Pathology Center, Vilnius
University Hospital Santariskes Clinics, Lithuania
Virtual Double Staining for Optimization and Standardization of
Quantitative Immunohistochemistry
In immunohistochemistry, digital pathology allows objective and
standardized quantitative assessment of biomarkers, but there are
many methodological issues. Virtual Double Staining overcomes some
of the challenges pathologists face with both pattern recognition and
physical double staining. In a collaboration between Nordic
Immunohistochemical Quality Control (NordiQC) and Visiopharm, a
leader in Quantitative Digital Pathology, applications have been
developed for the analysis of proliferation markers in cancers and
hormone receptors in breast cancer. These applications may be used in
a clinical setting as well as for internal and external quality assurance
of immunhistochemical staining.
CONFIRMED:
Mogens Vyberg, Professor of Clinical Pathology, University of
Aalborg, Denmark
Is Digital Pathology Ready for Use in Routine Histopathology?
This presentation reviews the challenges presented in moving from
conventional light microscopes to digital pathology (DP) workstations
for routine diagnostic histopathology, the approach taken at UHCW to
achieve this, why such a move is worthwhile and what it’s potential is
for improving our pathology service in the future.
An important aspect of this project has been the validation of DP, i.e.
an assessment of how effective pathologists are when using digital
images, as opposed to conventional microscopes, in their routine
diagnostic reporting. The UHCW project has used existing data on
inter and intra observer variability to design a non inferiority study of
sufficient power to provide statistically significant results. This is the
largest study yet conducted and it’s results are expected to inform the
debate on the validity of DP in primary diagnosis globally. The project
has also examined the expected return on the investment made, the
mechanism for delivering increased efficiency with digital pathology
systems, and the potential for improving pathology through the use of
digital pathology.
CONFIRMED:
Johan Lundin, Research Director and Professor of Medical
Technology, Institute for Molecular Medicine Finland (FIMM),
Helsinki, Finland and Karolinska Institutet, Stockholm, Sweden
Has Digital Pathology Become Integrated Standard in Pathology
Education or is it its Use Still Exception?

Opportunities being offered by using combined methods of
digital pathology and traditional pathology in
undergraduate, as well as post graduate education of
pathology.

Obstacles and cost benefit issues of setting and maintaining
digital pathology educational sites

An overview of current projects and educational material in
pathology in EU

Our experience and reflection on its certain aspects
influencing consequently the quality level of education
CONFIRMED:
Sanja Stifter, Associate Professor, Department of Pathology, Faculty
of Medicine, University of Rijeka, Croatia
Application of Pattern Recognition Software on Preclinical and
Safety Studies

Pattern recognition software with a view to:

Hierarchical/tiered workflows and utilisation on preclinical
and safety tissues prior to or in conjunction with ‘routine
analysis’

Comparison of 4 different pattern recognition software
systems in the evaluation of progesterone receptor in breast
TMA

Current applications and future integrations within the drug
discovery process and potential translation to companion
algorithms
CONFIRMED
CONFIRMED:
David Snead, Consultant Histopathologist and Clinical Service Lead, Alison Bigley, Associate Principal Scientist, Investigative &
Translational Pathology, AstraZeneca, UK
Coventry and Warwickshire Pathology Services, UK
15.15-15.45
Solution Provider Presentation
Solution Provider Presentation
Title to be Confirmed
Han van Krieken, Full Professor, Pathology, Radboud University
Medical Centre
15.45-16.35
For sponsorship opportunities please contact Steve Hambrook
at steve@globalengage.co.uk
Afternoon Refreshments & Poster Presentation Sessions
One-to-One Meetings
For more information please contact Steve Hambrook, Conference Director, Global Engage Ltd.
steve@globalengage.co.uk
+44 (0) 1865 849841
Day One (cont.) – Thursday, 4th December
16.35-17.00
17.00-17.25
Advanced Image Analysis Bridging Tissue Biomarker Discovery
from Experimental to Clinical Studies
Digital pathology enables context-related, comprehensive analysis of
tissue biomarkers beyond measurements of cell densities and staining
intensity. The presentation provides examples for successful
implementation of advanced image analysis modules in exploratory
and clinical studies, and points out perspectives how this technology will
help bridging between the experimental setting under laboratory
conditions and the reality of biomarker programs in clinical studies.
CONFIRMED:
Friedrich Feuerhake, Neuropathologist, Institute of Pathology,
Hannover Medical School, Germany
Relevance of Digitised Synoptic Reporting in Ovarian Cancer
The Synoptic (“Structured” or “Templated”) Reporting constitutes the
standard of reporting practice and is best developed in diagnostic
pathology of cancers. The mandatory Cancer Protocols (and/or
modified) incorporated into the LIS relational database, facilitate
access to desired information and improve communication for
appropriate cancer management. The gross and microscopic digital
images (WSIs, IHC and auxiliary studies) form the diagnostic vs.
consultative database for the pathological examination and the further
quantitative study. The uniform virtual repository allows easy data
extraction for the quality improvement and cancer surveillance by
cancer registries. The lecture will provide conclusive information on the
synoptic reporting in cancer pathology service; present pilot study on
the ovarian carcinoma templated reporting introduced in the MIM
(Poland) - its benefits, transient barriers and limitations.
CONFIRMED::
Janina Slodkowska, Department of Pathology, Consultant
Specialist, Military Institute of Medicine, Poland
Towards Fully Automated Computer Aided Diagnosis in Pathology
Large scale introduction of whole slide imaging is still not a reality in
clinical pathology, mainly due to associated high costs. Expectedly, the
availability of validated computer aided diagnosis (CAD) algorithms
will push the balance to a favorable business case. In this talk, results of
our current research on CAD techniques and validation are presented.
We successfully developed algorithms applying digital image analysis,
to recognize tumor areas, quantify tissue features related to cell nuclei,
tissue architecture, relationships between cells of different types en
tissue texture.
CONFIRMED:
Jeroen van der Laak, Assistant Professor in Digital Pathology, Dept
of Pathology, Radboud University Nijmegen Medical Centre, The
Netherlands
Title to be Confirmed
CONFIRMED:
Rob Goldin, Professor of Liver & GI Pathology, Faculty of
Medicine, Department of Medicine, Imperial College London, UK
17.25-17.50
Digital Pathology and the Use in the Clinic and in Research
17.50-18.50
CONFIRMED:
Eric Verbeeken, Professor, The Translational Cell and Tissue Research Group, KU Leuven, Belgium
Chairman’s Closing Remarks and End of Day 1
Drinks Reception
For more information please contact Steve Hambrook, Conference Director, Global Engage Ltd.
steve@globalengage.co.uk
+44 (0) 1865 849841
Agenda: Day Two – Friday, 5th December 2014
08.00-08.40
08.40-09.10
09.10-09.40
Morning Coffee
One-to-One Meetings
County Hall Suite - Stream Chair – Kate Lillard, Chief Scientific Officer, Indica Labs Inc.
Keynote Address
Standardisation in Digital Pathology
Future advances in digital pathology will need to include medical image standardization related to DICOM and HL7 standards. In addition, this
will likely involve expansion of the IHE Anatomic Pathology technical frameworks, and SNOMED CT broader use. The main advantage of using
the DICOM standard instead of proprietary file formats is to store pathology images in a PACS, like radiologists or cardiologists do.
Governance in pathology information technology standards needs active input from national and international pathology associations, in
coordination with major international general standardization bodies (e.g. ISO, ITU), and specific standards development groups (e.g. DICOM,
HL7, IHE, SNOMED CT). It is important that pathology images can also be incorporated into the patient’s health record.
CONFIRMED:
Marcial Garcia Rojo, Head of Pathology Department. Hospital de Jerez de la Frontera, Cádiz, Spain
Primary Diagnostics in Pathology Using Whole Slide Images
Working with whole slide images potentially offers many advantages for the pathologist. Many of these have already found their way to
daily practice, like digital teaching, digital archiving, digital slide panels, and digital consultation and revision. One area which is emerging
now is primary diagnostics using whole slide images. In this presentation, the ins and outs of primary digital pathology diagnostics will be
discussed based on an analysis of currently available technology and literature on reliability of primary digital diagnostics.
CONFIRMED:
Paul van Diest, Head of Department, Professor in Pathology, University Medical Center Utrecht, Netherlands
09.40-10.10 Solution Provider Presentation
Reproducibility in Digital Pathology – The Last Step or The First in Standardization
Increasing usage of digital pathology is promoting greater sharing of slides between organisations, often highlighting the different staining
patterns and preferences between laboratories. Is this inherent variability in slide preparation something we should adjust for with digital
pathology, or eliminate before slide scanning? We will look at a study measuring haematoxylin and eosin variation in serial sections and the
challenges and benefits of utilising digital pathology, despite this variability.
CONFIRMED:
Olga Colgan, Director of Commercial Marketing, Aperio ePathology, Leica Biosystems, Dublin, Ireland
10.10-11.20
Morning Refreshments
Poster Presentation Sessions
Scheduled One-to-One Meetings
11.20-11.45
Variation in Digital Pathology Scanning
There are a number of Digital Pathology Vendors on the market offering tile or line-scanning, with a variety of calibration techniques
associated with this. The assumption is that every slide will be scanned identically providing reproducible analysis data to the user every time.
We have performed a reproducibility study on 3 digital pathology systems before and after re-calibration to examine the inherent variability
in the scanning systems and how this variability affects image analysis results.
CONFIRMED:
Will Howat, Head of Histopathology/ISH, Cancer Research UK
11.45-12.15 Solution Provider Presentation
TissueMark: Automated Image Analysis for the Calculation of % Tumour Nuclei in Molecular Pathology
Visual estimation of % tumour nuclei shows gross variation between laboratories and between pathologists, potentially resulting in inaccurate
molecular testing and patient therapy.
Within PathXL’s automated tumour annotation and analysis software TissueMark, we have developed a ‘cell counting calculator’, calculating %
tumour nuclei using automated image analysis on H&E digital slides. Validation was performed by comparing automated % tumour nuclear
counts using TissueMark technology with manually hand-counted nuclei in a series of breast, lung and colorectal images. There was strong
correlation between TissueMarks automated % tumour nuclear calculations and manual nuclear counts across all three tissue types. This
represents a novel approach for precisely measuring % tumour cells in tissue samples for molecular evaluation, improving reliability in discovery
and diagnostics.
12.15-12.45
CONFIRMED:
Peter Hamilton, Professor, Head of Bioimaging and Informatics Research Group, Queens University Belfast
Panel Discussion – Overcoming Barriers in Adoption of Digital Pathology
CONFIRMED:
Keith Kaplan, Pathologist, Charlotte, NC, USA
Liron Pantanowitz, Associate Professor of Pathology & Biomedical Informatics, Director of the Pathology Informatics Fellowship Program
and Associate Director of the Pathology Informatics Division at the University of Pittsburgh Medical Center, USA
Paul van Diest, Head of Department, Professor in Pathology, University Medical Center Utrecht, Netherlands
Yukako Yagi, Director of the MGH Pathology Imaging & Communication Technology (PICT) Center
Massachusetts General Hospital; Affiliated Faculty, Wellman Center for Photomedicine, Massachusetts General Hospital; Assistant
Professor of Pathology, Harvard Medical School, USA
Marcial Garcia Rojo, Head of Pathology Department. Hospital de Jerez de la Frontera, Cádiz, Spain
12.45-13.45
Toby Cornish, Assistant Professor of Pathology, Division of Gastrointestinal and Liver Pathology, Associate Director of the Pathology
Informatics Division, Johns Hopkins School of Medicine, USA
Lunch
Poster Presentation Sessions
Scheduled One-to-One Meetings
For more information please contact Steve Hambrook, Conference Director, Global Engage Ltd.
steve@globalengage.co.uk
+44 (0) 1865 849841
Day Two (cont.) – Friday, 5th December 2014
13.45-14.10
14.10-14.35
14.35-15.00
15.00-15.15
15.15-15.45
15.45-16.10
16.10-16.35
16.35-17.00
AngioPath: Morphometric Tool for Vessel Segmentation in Angiogenesis Research
Given that angiogenesis and lymph angiogenesis are strongly related to prognosis in neoplastic and other pathologies and that many methods
exist for their study providing different results, we aim to construct a morphometric tool allowing quantifying and measuring different aspects
of the shape and size of vascular vessels in a complete and accurate way. The developed tool is based on vessel closing which is an essential
property to properly count the number and characterize the size and the shape of vascular and lymphatic vessels. The method is fast and
accurate improving existing tools for angiogenesis analysis. The tool also improves the accuracy of vascular density measurements, since it
considered as a single object the set of endothelial cells forming a vessel.
CONFIRMED:
Gloria Bueno, Professor, VISILAB – School of Engineering, Universidad de Castilla-La Mancha, Spain
Global Insourcing of Pathology Consultation and Second Opinion Using Digital Pathology

Outline the opportunities and motivation for developing a global consultation and secondary opinion service

Discuss the significant logistical, cultural, political and technical barriers to realizing a global consultation service

Describe how digital pathology, in the form of web-based teleconsultation networks, enables a global consultation workflow
CONFIRMED:
Toby Cornish, Assistant Professor of Pathology, Division of Gastrointestinal and Liver Pathology, Associate Director of the Pathology
Informatics Division, Johns Hopkins School of Medicine, USA
Digital Image Analysis
CONFIRMED:
Marielle Odin, Director of Pathology, Roche, Germany
Applications of Virtual Microscopy in Routine Pathology
Adoption of virtual microscopy in diagnostic histopathology has been rather slow. It appears that simple slide viewing is equally easy with
conventional microscope than using a computer monitor. We hypothesize that pathologists could shift to use virtual microscopy when
applications where virtual microscopy could better or more efficient become available in an easy-to-use interface. These applications include
quick consultation, various length and area measurements, nuclear grading, cell counting, IHC analysis, multiple staining viewing, case
comparison, etc. We demonstrate our web-based virtual microscopy software, which includes a large set of useful applications in a simplified
virtual microscope user interface.
CONFIRMED:
Jorma Isola, Professor of Cancer Biology, University of Tampere, BioMediTech, Finland Digital Image Analysis
Afternoon Refreshments
Poster Presentation Sessions
A Virtual Thymoma Pathology Panel - Living Apart Together
Thymic tumours (thymoma and thymic carcinoma) are very rare tumours. Accurate histological subtyping using the WHO scheme and staging
are important factors determining prognosis and possible adjuvant treatment. Because of the low incidence and subsequent low exposure to
these rare tumours, typing is best performed by experts, preferably in a panel setting. However, panel meetings are constrained by time and
place. We formed a Virtual Thymoma panel, using virtual microscopy and a web-based reporting system to provide a diagnostic service to
submitting pathologists faced with thymic tumour specimens. The nature of the system released the time and geographic constraints, enabling
invitation of international experts to join the panel. Over 100 hundred cases have currently been diagnosed by the panel.
CONFIRMED:
Michael den Bakker, Consultant Histopathologist Department of Pathology, Maasstad Hospital, The Netherlands
Data Mining for Research and Diagnostics

Description of our image generation and analysis pathway. The setup is suitable for fast turnaround diagnostics as well as for
extensive research programmes.

Generation of an algorithm to compare different brain sections to effectively remove mathematically all the curves of the human
brain. We will show how to match large numbers of brain sections to compare similarities or difference between dozens or even
hundreds of samples.

Evaluation of a rapid throughput image analysis for tissue based molecular diagnostics.

Examples for biomarker identification: Correlation of imaging and expression analysis data in an experimental models for brain
tumours
CONFIRMED:
Sebastian Brandner, Professor and Chair of Neuropathology, Division of Neuropathology, The National Hospital for Neurology and
Neurosurgery, and Dept. of Neurodegenerative Disease, UCL Institute of Neurology, UK
Colorimetric Detection of Prostate Cancer in Grid Regions Utilizing a Ratio of Racemase to High Molecular Weight Keratin (HMWK) and
P63
We seek to improve multiparametric MRI methods for defining prostate cancer (PCa) in vivo. We spatially coregister preoperative MRI data
with postoperative pathology data (prostatectomy whole slide images, WSI). Workflows involve pathologist annotation of PCa; the resulting
data is incomplete since WSI regions "looped in" as PCa are variably composed not only of cancer epithelium, but additionally tissue elements
including stroma, benign epithelium, and gland lumens. Statistical analyses may benefit by dividing PCa-containing regions into subregions
and, within subregions, determining the fractional composition of tissue elements. We have developed a multicolor approach (racemase in red,
basal cells in brown, stroma in blue/ hematoxylin, gland lumens in white) and image analysis methods to identify PCa-containing regions and,
within subregions, estimate the fractional composition of tissue elements.
CONFIRMED:
Stephen Schmechel, Associate Professor, Chief of Pathology (Acting), Harborview Medical Center, Department of Pathology, University of
Washington School of Medicine, USA
Chairman’s Closing Remarks and Conference Close
For more information please contact Steve Hambrook, Conference Director, Global Engage Ltd.
steve@globalengage.co.uk
+44 (0) 1865 849841
Poster Presentations
The conference will also host a range of poster presentations for you to study and to discuss with the presenters during designated
sessions.
Here are the titles of some examples of already approved abstracts:
Title
Prognostic significance of image analysis of blood
vessels differentiated by segments rather than global
vascularization
Principal Author(s)
Affiliation
Tadeo I, Berbegall AP, Cañete A,
Bueno G, Navarro S, Noguera R
Department of Pathology, Medical
School, University of Valencia INCLIVA, Valencia, Spain
Zúñiga V, Machado I, Tadeo I,
Berbegall AP, Cañete A, Navarro S,
Noguera R
AL-SAM S Z, JADER S N,
ARKOUMANI, E, GOPINATH P,
Can we achieve consistency through digital pathology? ALZADJALI A, PRODROMOU A and
FORSYTH K
Department of Pathology, Medical
School, University of Valencia INCLIVA, Valencia, Spain
A system for joint pathology and molecular data
analysis
Histopathological Image Analysis for Determining
Tissue Composition in Gastric Cancer
Vlad Popovici
Institute of Biostatistics and Analyses,
Masaryk University
Harshita Sharma
Charité - Universitätsmedizin Berlin
Image analysis of CD8 T cell effector subsets using
tissue microarrays in neuroblastic tumors
Benedict Griessmann, Maria
Deligiani, Philipp Ströbel MD,
Alexander Marx MD
Violeta N. Kovacheva, David Snead,
A Spatial Model of the Colonic Crypt Microenvironment Nasir M. Rajpoot
Nina Linder, Sami Blom, Panu
A Systems Pathology Approach to Compare Preclinical Kovanen, Anne Grote, Riku Turkki,
Mikael Lundin, Teijo Pellinen, John
Models with Human Cancer
Hickman, Olli Kallioniemi, Johan
Lundin
Attempt to classify thymic neuroendocrine carcinomas
by an automatic Ki67-and H3- evaluation
The Princess Alexandra Hospital
Institute of Pathology, University
Medical Centre Mannheim, University
of Heidelberg
University of Warwick
Institute for Molecular Medicine Finland
(FIMM), University of Helsinki, Finland
1University
Shan-e-Ahmed Raza1, Qaiser
Anisotropic Tubular Filtering for Automatic Identification Marjan2, Muhammad Arif2, Farhana
Butt3, Faisal Sultan3, Nasir M.
of Acid Fast Bacilli in Sputum Smear Samples
Rajpoot1,4
SecundOS: A Belgian digital pathology initiative to
implement an inter-university network for second
opinions and collaboration between expert pathologists
X Moles Lopez1,2, C Maris1, T
Chattway1, M Remmelink1, B
Weynand3, S Rorive1,2, C
Decaestecker2, I Salmon1,2
of Warwick, Coventry, UK.
Institute of Engineering and
Applied Sciences, Islamabad, Pakistan.
3Shaukat Khanum Memorial Cancer
Hospital & Research Centre, Pakistan.
4Qatar University, Qatar
1. Department of Pathology, Erasme
Hospital, ULB, Brussels, Belgium.
2. Diapath, Center for Microscopy and
Molecular Imaging (CMMI), ULB,
Gosselies, Belgium.
3. Department of Pathology, CHU
Dinant-Godinne, UCL, Yvoir, Belgium.
2Pakistan
Making a poster presentation
Poster presentation sessions will take place in breaks and alongside the other breakout sessions of the conference. Your
presentation will be displayed in a dedicated area, with the other accepted posters from industry and academic presenters.
We also issue a poster ebook to all attendees with all abstracts in full.
Whether looking for funding, employment opportunities or simply wanting to share your work with a like-minded and focused
group, these are an excellent way to join the heart of this congress.
In order to present a poster at the forum you need to be registered as a delegate. Please note that there is limited space
available and posters space is assigned on a first come first served basis (subject to checks and successful registration).
For further information on submission, approval and the technical poster spec, please contact submit@globalengage.co.uk
For more information please contact Steve Hambrook, Conference Director, Global Engage Ltd.
steve@globalengage.co.uk
+44 (0) 1865 849841
Digital Pathology Congress – 4-5 December 2014, London, UK
How To Register
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THE DELEGATE BOOKING FEE INCLUDES:
All meals and refreshments throughout the conference day,
conference presentations, open workshop and general
panel sessions and networking/social events, conference
and speaker notes.
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ORDER CONFERENCE DOCUMENTATION:
I cannot attend the conference but wish to buy the
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Full documentation costs £250.
To order, complete the registration form and
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