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MAKING SENSE OF THE SEQUENCE:
GENOMICS PRIMER FOR CLINICAL
CANCER GENETIC PRACTITIONERS
April 11-12, 2014
Sponsored By:
THE UNIVERSITY OF CHICAGO
DEPARTMENT OF MEDICINE
Section of Hematology and Oncology & The Center for Clinical Cancer Genetics
In Collaboration with The City of Hope
Division of Clinical Cancer Genetics
HYATT CHICAGO MAGNIFICENT MILE
633 N St. Clair Street
Chicago, IL 60611
CONFERENCE CO-DIRECTORS
Olufunmilayo I. Olopade, MD, FACP
Walter L. Palmer Distinguished Service Professor
Department of Medicine and Human Genetics
Director, Cancer Risk Clinic
The University of Chicago
Sonia S. Kupfer, MD
Assistant Professor of Medicine
Section of Gastroenterology
Department of Medicine
The University of Chicago
Register online at: cme.uchicago.edu
This educational activity is funded in part by:
Ralph and Marion Falk Medical Research Trust
Entertainment Fund National Women’s
Cancer Research Alliance
CONFERENCE DESCRIPTION
Rapid advances in genetic and genomic technologies have revolutionized our approach to cancer risk
assessment, screening, prevention, and targeted cancer therapies, heralding the era of personalized precision
medicine. The challenges of genetic and genomic counseling include the need for professional education
and evidence-based information regarding the clinical utility of testing for genetic variants, approaches
to interpreting genomic information, and the need to develop new clinical models to improve access to
and responsible communication of complex genomically-informed cancer risk assessment and patient
care. The introduction of affordable next generation sequencing (NGS) applications, including multigene panels and whole exome/genome analysis, is ushering a wealth of data on both rare and common
genetic variants into the arena of clinical medicine. The applications are rapidly changing the landscape
of personalized cancer risk assessment, treatment, and preventive care.
LEARNING OBJECTIVES
At the conclusion of this educational activity, participants should be able to:
• Review basic concepts in genetics, genomics, and next generation sequencing (NGS) technologies
• Explore the benefits and limitations of applying NGS information to clinical genetic/genomic
cancer risk assessment practice
• Recognize the impact of current advances in somatic genomics and pharmacogenomics on
oncology practice
• Discuss strategies for appropriate selection of NGS tests, and interpretation and communication
of NGS information into personalized patient care as well as diffusion of technology and
knowledge on a global scale
• Provide a forum to bring together national and international academic and community clinicians
researchers to foster collaborations, emphasizing opportunities for cancer epidemiology cohort
studies
• Enable young investigators to participate as conference faculty and to generate ideas for
clinical, basic science, and translational research in genomics for implantation in patient care
Please join us for what promises to be an informative and thought-provoking conference!
TARGET AUDIENCE
This activity has been planned for Oncologists, Primary Care Physicians, Gastroenterologists, Gynecologists,
Obstetricians, Pediatricians, Surgeons as well as Genetic Counselors, Nurses, Nurse Practitioners, Physician
Assistants and Social Workers.
ACCREDITATION AND CREDIT DESIGNATION
The University of Chicago Pritzker School of Medicine is accredited by the Accreditation Council for
Continuing Medical Education to provide continuing medical education for physicians.
GENERAL SESSIONS (FRIDAY and SATURDAY)
The University of Chicago Pritzker School of Medicine designates this live activity for a maximum 11
AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent
of their participation in the activity.
Nurses and other healthcare professionals will receive a Certificate of Participation. For information
on the applicability and acceptance of certificates of participation for educational activities certified
for AMA PRA Category 1 Credit™ from organizations accredited by the ACCME, please consult your
professional licensing board.
CONFERENCE LOCATION AND ACCOMMODATIONS
The conference will take place at
The Hyatt Chicago
Magnificent Mile
633 N. St. Clair Street
Chicago, IL 60611
888-591-1234
At the Hyatt Chicago Magnificent Mile
Hotel, you’re in the heart of Chicago, steps
from Michigan Avenue, the Gold Coast
neighborhood, and Lake Michigan. Our
classic urban hotel is a symbol of hospitality
on The Magnificent Mile. We are pleased to
offer a special discounted rate of $199.00
per night for single or double occupancy.
Room reservations must be made by March
20, 2014 to guarantee the reduced rate. All
rates are subject to state and city taxes and
must be guaranteed and accompanied by a
first night room deposit or guaranteed with
a major credit card. Check-in time is 3pm
and check-out time is 12 pm. Cancellations
must be received 24 hours prior to arrival or
1 night room and tax will be assessed.
To reserve a room at this special rate, please call the hotel toll free at 888-591-1234 and identify yourself
as part of the University of Chicago Cancer Genetics 2014 event or book online at: https://aws.passkey.
com/g/21640331
With a locale just one block from Michigan Avenue, near Chicago dining, shops, museums and art
galleries, this hotel provides a great base to explore exciting Chicago tourist attractions. Additionally,
you can maintain your healthy lifestyle with a satisfying workout in the fitness center or a swim in the
sparkling indoor pool.
Parking: The daily parking fee at the Hyatt Chicago Magnificent Mile is $20 for local registered attendees
driving to the conference.
Chicago is truly a city with something for everyone! To help plan your stay in Chicago visit: www.
choosechicago.com
EDUCATIONAL GRANTS/COMMERCIAL SUPPORT
A complete listing of commercial support received will be provided in the conference materials.
The University of Chicago reserves the right to cancel or postpone this conference due to unforeseen
circumstances. In the unlikely event this activity must be cancelled or postponed, the registration fee
will be refunded; however, The University of Chicago is not responsible for any related costs, charges,
or expenses to participants, including fees assessed by airline/travel/lodging agencies.
GUEST FACULTY
Fergus J. Couch, PhD
Professor of Laboratory Medicine & Pathology
Mayo Clinic
Judy E. Garber, MD, MPH
Professor of Medicine Harvard Medical School
Director, Center for Cancer Genetics and
Prevention Dana Farber Cancer Institute
Gad Rennert, MD, PhD
Chairman, Department of Community Medicine
and Epidemiology
Carmel Medical Center and
Technion Faculty of Medicine
Director, CHS National Israeli Cancer Control
Center
Colin C. Pritchard, MD, PhD
Assistant Professor, Laboratory Medicine
Associate Director, Clinical Molecular
Genetics Laboratory
University of Washington
UNIVERSITY OF CHICAGO FACULTY
Olufunmilayo I. Olopade, MD, FACP
(Co-Director)
Walter L. Palmer Distinguished Service Professor
Department of Medicine and Human Genetics
Director, Cancer Risk Clinic
Sonia S. Kupfer, MD (Co-Director)
Assistant Professor of Medicine
Section of Gastroenterology
Department of Medicine
Jane E. Churpek, MD
Assistant Professor of Medicine
Section of Hematology/Oncology
Department of Medicine
Soma Das, PhD
Professor
Director, Clinical Molecular Genetics Laboratory
Department of Human Genetics
Linda Patrick Miller, PhD
Assistant Professor
Section of Hematology/Oncology
Department of Medicine
Yusuke Nakamura, MD, PhD
Professor of Medicine
Section of Hematology/Oncology
Departments of Medicine
Sarah Nielsen, MS, CGC
Cancer Genetic Counselor
Section of Hematology/Oncology
Department of Medicine
S. Diane Yamada, MD
Professor of Obstetrics/Gynecology
Chief, Section of Gynecologic Oncology
Department of Obstetrics/Gynecology
Raymon Grogan, MD
Assistant Professor of Surgery
Director Endocrine Surgery Research Program
Department of Surgery
CITY OF HOPE FACULTY
Kathleen R. Blazer, EdD, MS, LCGC
Clinical Assistant Professor
Assoc. Director, Cancer Genetics Education Program
Division of Clinical Cancer Genetics
City of Hope
Jeffrey N. Weitzel, MD
Professor of Oncology and Population Sciences
Chief, Division of Clinical Cancer Genetics
City of Hope
FACULTY DISCLOSURE
It is the policy of the University of Chicago to ensure balance, independence, objectivity, and scientific rigor
in all its individually sponsored or jointly sponsored educational activities. Individuals who are in a position
to control the content of this educational activity are required to disclose all relevant financial relationships
with any commercial interest related to the subject matter of the educational activity. Mechanisms to ensure
that presentations are free from commercial bias are in place. Faculty will also disclose any off-label and/
or investigational use of pharmaceuticals or instruments discussed in their presentation. Full disclosure of
this information will be published in the activity materials.
CONFERENCE AGENDA
FRIDAY, APRIL 11, 2014
7:30-8:00 am CONTINENTAL BREAKFAST AND REGISTRATION
8:00-8:05 Welcome, Olufunmilayo I. Olopade, MD, FACP
8:05-10:00
Next-Generation Sequencing (NGS) for precision diagnosis and treatment
8:05-8:35 Current technologies, targeted sequencing vs. whole
exome/genome, Soma Das, PhD
8:35-9:05 Somatic mutation panels, Colin C. Pritchard, MD, PhD
9:05-9:35 Using NGS for personalized risk assessment and prevention
Olufunmilayo I. Olopade, MD, FACP
9:35-10:00 Panel Discussion
10:00-10:15 MORNING BREAK
10:15-11:00 Keynote Address I: Pharmacogenomics of breast cancer treatment
Judy E. Garber, MD, MPH
11:00-12:15 pm Case working of NGS testing with expert panel
Cases
12:15-1:30
LUNCH Opportunity to network
1:30-2:15 Keynote address II: Using NGS for identifying treatment targets
Yusuke Nakamura, MD, PhD
2:15-3:30 The Vast Unknown of VUS and rare variants
2:15-2:45 Novel approaches to functional studies, Fergus J. Couch, PhD
2:45-3:15 International VUS consortia & reclassification efforts
Jeffrey N. Weitzel, MD
3:15-3:30 Panel Discussion
3:30-3:45 AFTERNOON BREAK
3:45-5:00 Case Working of VUS/rare variants with expert panel
3:45-4:15Genetic cancer risk assessment in the face of uncertainty Kathleen R. Blazer, EdD, MS, LCGC
4:15-5:00Cases
5:00-6:30 pm WELCOME RECEPTION
7:30-8:00 am CONTINENTAL BREAKFAST AND REGISTRATION
7:50 Announcements, Sonia S. Kupfer, MD
8:00-10:00 Diffusion of Genomics in Clinical Practice
8:00-8:30 Role of multi-speciality clinics for hereditary cancer
management: VHL as an example, Sarah Nielsen, MS, CGC and
Raymon Grogan, MD
8:30-9:00 Application of genomics in care of GI Malignancies
Sonia S. Kupfer, MD
9:00-9:30 Update on prevention of Ovarian Cancer in at risk patients
S. Diane Yamada, MD
9:30-10:00 Genomics of hematological malignancies and secondary
leukemia, Jane E. Churpek, MD
10:00-10:15 MORNING BREAK
10:15-11:00 Keynote Address III: Population-based genomic testing to personalize
cancer prevention in Israel, Gad Rennert, MD, PhD
11:00-12:15 pm Ethical, Legal & Psychosocial Aspects of genomic testing
11:00-11:30 Should we disclose genetic/genomic test results by telephone?
Linda Patrick Miller, PhD
11:30-12:00Cases
12:00-12:15 Concluding Remarks
12:30-5:00 pm Special Breakout Session for City of Hope Intensive Course Alumni &
Clinical Cancer Genetics Community Research Network (CCGCRN)
Lunch will be provided
Program agenda and speaker selection subject to change.
CLIP HERE TO MAIL IN REGISTRATION FORM
SATURDAY, APRIL 12, 2014
✁
REGISTRATION
The registration fee includes conference materials, an electronic syllabus, continental breakfast, refreshment breaks,
lunch, and welcome reception. You may register online or US mail. While registration is open until the start of the
meeting, we encourage early registration to enable us to provide the best possible service to participants.
HOW TO REGISTER
ONLINEhttp://cme.uchicago.edu (credit card payment only)
To pay by check, you must mail your registration with payment to:
MAILThe University of Chicago
Center for Continuing Medical Education
c/o Cancer Genetics 2014
950 East 61st Street, Suite 101
Chicago, IL 60637
On or Before
March 14
After
March 14
Physician
$275
$350
Genetic Counselors
$175
$225
Nurse/PA/Allied Health Professionals
$175
$225
Industry
$275
$350
Resident/Fellow (fax letter of verification to 773-702-1736)
$125
$200
Payment Total $_________
If you are a member of the CCGCRN (Clinical Cancer Genetics Community Research Network)
please enter the registration code you received from City of Hope here: ____________________
PAYMENT
o Check enclosed (U.S. funds only), payable to University of Chicago (Tax ID# 36-2177139)
CONTACT INFORMATION
Name
Degree
Specialty
Organization
Mailing Address
City
Phone
State
Zip
Fax
Email
PLEASE CHECK ALL THAT APPLY
o You must check this box if you do not want your mailing address shared with conference participants and
exhibitors (if applicable).
Do you plan to attend the Friday Welcome Reception?
o Yes o No
Please tell us how you found out about this activity, check all that apply:
o Colleague o Save the Date o Brochure o Internet o Email o Journal Ad o Previous Attendance o Other
CANCELLATION POLICY
If you cancel your participation in this conference, your registration fee, less a $100.00 administrative fee, will be
refunded when written notification is received by March 21, 2014. No refunds will be issued after March 21, 2014.
ACCESSIBILITY
The University of Chicago is committed to providing equal access appropriate to need and circumstance and complies fully with the legal
requirements of the Americans with Disabilities Act. If you are in need of special accommodation, please contact our office at 773-7021056 or via email at cme@bsd.uchicago.edu.
For additional information about this activity, please call the Center for Continuing Medical Education at 773.702.1056.
HYATT CHICAGO MAGNIFICENT MILE
633 N St. Clair Street
Chicago, IL 60611
April 11-12, 2014
GENOMICS PRIMER FOR
CLINICAL CANCER
GENETIC PRACTITIONERS
MAKING SENSE OF THE SEQUENCE:
The University of Chicago
Center for Continuing Medical Education
950 East 61st Street, Chicago, IL 60637
PAID
PLEASE POST
WHEELING, IL
PERMIT NO. 281
NON-PROFIT
ORGANIZATION
U.S. POSTAGE