ISBN 978-93-5173-179-3 http://www.ayurlog.com ISSN 2320-7329 Issue- 1st Jan- Mar 2015 Vol. 3 Ayurlog: National Journal of Research in Ayurved Science A Web based quarterly online published Open Access peer reviewed National E-journal of Ayurved Clinical Trials Of Kamdudha Vati In Mukhapak __________________________________________________________________________ Nilakshi Pradhan*1 ___________________________________________________________________________ 1. Principal & Professor Department of Shalakya tantra, SSAM, Hadapsar, Pune-28, Maharashtra. * Corresponding Author: E-mail: drnspradhan@yahoo.com Mob-9423580963 ___________________________________________________________________________ Abstract : kamdudha only systemically. It may prove Mukhapak is a commonest disease of mukha better found in India as well as all over the World. administration of kamdudha. combination than only systemic In this condition mukha is affected by paka process which is always associated with pitta Key wards: Mukhapak, sarvsar, stomatitis, dosha. Due to ulceration irritation, pain, pratisaran, pitta prakop, ropan, daha. burning sensation is experienced when Introduction: The symptoms of Mukhapak patient take food. Sometimes liquid intake can be correlated with stomatitis. It is also becomes troublesome as cold or hot an inflammation of the mouth and lips. It sensation gives lot of pain burning sensation affects the mucous membranes of the mouth etc. It is very important to have effective, economic & without and lips, with or without ulceration. In widest any side effect, meaning, stomatitis can have a multitude of medicine on it. Here an attempt to try different causes. The commonest causes Ayurvedic drug Kamdudha systemically as which well as locally as an application. It was includes infections, nutritional deficiencies, allergic reactions, radiotherapy observed that healing rate of ulceration was etc.[1] fast in those patients who received kamdudha by both the ways than who received 1 ISBN 978-93-5173-179-3 http://www.ayurlog.com ISSN 2320-7329 Issue- 1st Jan- Mar 2015 Vol. 3 Ayurlog: National Journal of Research in Ayurved Science A Web based quarterly online published Open Access peer reviewed National E-journal of Ayurved common in poor & uneducated class [5]. Also Food is the factor which sustains & supports the dhatu oja & bala i.e.strength or alcohol capacity to perform physical work. Food is a chewing is very common in them. All the basic requirement of the body. Food in any above mentioned causes create stomatitis form either liquid or solid is very essential which is very common in our country [6]. for growth of body and maintenance of consumption, tobacco; gutka In modern medicine there is no health. Restriction of food by any reason can specific create a serious condition. The disease Combinations mukhapak can occur if it is neglected or not inflammatory are generally used in form of treated properly paste, gel or solution for gargles, which gives Mukhapak is a common disease of the oral cavity [2] treatment of for antibacterial stomatitis. & anti- symptomatic relief by cooling soothing effect [7] . It affects patient’s daily . As they are more in price also contains routine. It is found more in pitta pradhan side effects with them. Considering all the dosh, pitta pradhan prakruti & pittaj kala. It facts it is necessary to have effective, cost is more found in India because people are free drug which does not have any side more prone to have pitta prakopak ahar like effects. This project is devoted for the same spicy oily food, tobacco chewing, smoking, purpose & hence the following pages are the alcohol consumption etc. and also pitta result of this attempt. prakopak Aim & Objectives: vihar like late night sleeping,  improper timing of meals etc. Due to the paka process, ulcers & inflammation over affected area is seen in mukha [3] to Ayurveda  . There are various causes which create . Hence directly increasing To study stomatitis according to modern medical science  mukhapak like rapidly increasing problems [4] To study Mukhpak vyadhi according poverty To study the role of pratisaran chikitsa & efficacy of kamdudha in proportionally this has brought illiteracy, ill Mukhapak vyadhi  health with it. Because of malnutrition anemia stomatitis can occur. Bad hygiene is To study the importance of systemic effects of kamdudha in Mukhpak one of the major reasons which are very 2 ISBN 978-93-5173-179-3 http://www.ayurlog.com ISSN 2320-7329 Issue- 1st Jan- Mar 2015 Vol. 3 Ayurlog: National Journal of Research in Ayurved Science A Web based quarterly online published Open Access peer reviewed National E-journal of Ayurved sensitivity & pain index is different the study Methodology: The study of this project is totally was more based on clinical observations. based on clinical observations & the patient’s Duration of trial: The patients in the trial narration. The patient selected for this project group were treated systemically for duration will be treated systemically with kamdudha of 7 days treatment with kamdudha vati in & locally with kamdudha churna pratisaran the dose of 500 mg three times a day. [8] . This might prove that local application of Whereas in control group, according to the kamdudha churna along with systemic severity of the disease, local application of treatment enhances anti-inflammatory action 250 mg kamdudha churna 3 times a day. & faster rate of healing with better results [9] . Inclusion criteria: Inclusion criteria were The yogvahi & vishaghna property of goghrit done on the basis of randomization. This will act as catalyst along with vranaropak includes and pittaghna property of gairik. Also 1. Age is no bar tridoshaghna & vranaropak property of 2. Patients having ulcers in oral cavity amalaki will help to enhance the properties 3. Patients ready for drug trial- patients of gairik & thus anti-inflammatory action were given an idea of the project with ropan will be triggered [10] before giving the drug trial. . Group A- Trial group (total 30 patients) These patients were received Exclusion criteria: The patients who could systemic not come for follow up regularly to outdoor treatment of kamdudha with local application patients OPD were excluded. of kamdudha churna (pratisaran) The patients who were selected for Group B- control group (total 30 patients) this project had a similar study method. As These patients were received only systemic mentioned earlier the study was totally based administration with kamdudha on the patient’s narrations & clinical Design of study: observations. The patients were given drug An open comparative study was done of seven days which was in form of tablet for depending on the patients narration & clinical observations as oral ingestion & powder for local application every patients thrice a day. Follow-up was done every day. 3 ISBN 978-93-5173-179-3 http://www.ayurlog.com ISSN 2320-7329 Issue- 1st Jan- Mar 2015 Vol. 3 Ayurlog: National Journal of Research in Ayurved Science A Web based quarterly online published Open Access peer reviewed National E-journal of Ayurved Elder person with the patient were advised to in pitta pradhan desh ,pitta pradhan prakruti give the drug regularly for seven days. & in pittaj kala[11]. The subjective gradations of these The occurrences of symptoms in symptoms were done as follow & intensity of both the groups were same. The symptoms each system was calculated & was compared relieved in the patients of both the groups with that of other group i.e. control group. were compared & also shown graphically. It The subjective gradations of the symptoms showed that kamdudha given systemically was done as follows with locally worked more effective in  Grade 0 - No pain relieving all the symptoms than only  Grade + - Mild pain systemic administration of the drug.  Grade ++ - Moderate pain  Grade +++ - Severe pain  Grade ++++ In group A, result were found as 88% of patients had total relief of all the symptoms on the 7th day. Total 3.3% patients - Extreme pain had no relief at all. In group B, 75% of Similar graduation chosen for this patients got relief on 7th day. 6.6% of trial study was found commonly & which patients had no relief. was given a total idea of treating process. Discussion: Observations and Results: In this study, efforts were made to use From the study, it was observed that Ayurvedic drug kamdudha which is cost mukhpak is a common disease in all the age effective & alternative treatment for modern groups of present era. It is more common in line of treatment of mukhapaka. The ratio of young as pittapradhanyata found in young male to female was 24:36. age. Stomatitis has become very common Due to many reasons it occurs in problem in the present era. It is very mouth. In this disease mukha is affected by important to have effective, economic & paka procedure which is always associated without any side effect, medicine on it. So with pitta dosha. So mukhapak is more found here an attempt is made to treat stomatitis with kamdudha. As kamdudha is pitta 4 ISBN 978-93-5173-179-3 http://www.ayurlog.com ISSN 2320-7329 Issue- 1st Jan- Mar 2015 Vol. 3 Ayurlog: National Journal of Research in Ayurved Science A Web based quarterly online published Open Access peer reviewed National E-journal of Ayurved shamak in nature, it is useful to suppress 1. Text book of diseases of Ear-Nose- pitta dosha. It also contains vranropan Throat by K.B. Bhargav, S.K Bhargav, property which helps in healing of ulceration and T. M. Shah, 6th Edition, Chapter No. faster. Kamdudha contains sheet (cooling) 37, Page No. 211. property which helps to reduce burning 2. sensation present over the affected area. 1984, does not have any side effect. In fact as sensation, by Agnivesh, by Yadavji Chaukhamba Trikamji prakashana, Varanasi, Edition: Reprint 2009, Chikitsa haematinic. Also with the faster healing rate burning edited Acharya, gairik contains iron and proved as a good ulcers, samhita Chakrapani Tika, Chaukhamba orientela Unlike modern medicine kamdudha of Charak shana 26, page No. 889 pain, inflammation, dysphagia etc. reduced faster 3. Sushrut Samhita of Sushruta with in those patients who received kamdudha Nidan Sangraha commentary of Shri. systemically as well as locally. Dalhanacharya Conclusion : From the given observations Panjika of Shri. Acharya on Nidansthana, we can come to the following conclusions: edited by Yadavji Trikamji Acharya,  Nidanasthana 16, page No. 314 Mukhpak is one of the commonest oral & Nyaya Chandrika diseases in India.  Mukhpak is found in all the age groups.  Mukhpak is found more in pitta –prakruti 4. Madhav Nidan by Madhavkara- with commentary Vijayrakshit persons.  Use of & Madhukosh by Shrikanthadatta with extracts from Atankdarpan by Vachaspati Use of kamdudha in mukhpak is found to Vaidya, edited by vaidya Yadhavji be effective.  of kamdudha locally Trikamji Acharya-1955 with systemically is found more effective than 5. Text book of diseases of ear-nose- only systemic administration. throat by P.L. Dhingra. Page No. 202, 4th Edition. Reference: 5 ISBN 978-93-5173-179-3 http://www.ayurlog.com ISSN 2320-7329 Issue- 1st Jan- Mar 2015 Vol. 3 Ayurlog: National Journal of Research in Ayurved Science A Web based quarterly online published Open Access peer reviewed National E-journal of Ayurved 6. Text book of diseases of Ear-NoseThroat: Dhingra, 2nd Edition, 9. Bhavprakash Nighantu (Indian Materia B.I. Medica) of Shri.Bhavmishra Churchill Living Stone Publication at Commentory by Dr. K. C. Chunekar, New Delhi, Chapter no.42, Page No.215. Edited by Dr.G.S.Pandey, 10th edition 7. Text book of diseases of Ear-Nose- 10. Throat diseases by Dr. Mohammad Ayurvedic Maqbool, Jaypee councils for research in Ayurved & brother medical publishers 1993, 6th Edition, Chap-41, Pharmacopoeia formulation standards by for central Siddha. 1st Edition, 1990. Page No.328. 11. Ashtang hridaya – with commentary 8. Rasyogsagar- Satippan with Hindi of Arundatta & Hemadri Nirnay sagar Tika press- Bombay, uttarsthana 21, 22, Page by Vaidyapandit Hariprappan Sharma, Krishnadas Ayurved series-7,1st No.855. Part, Chap-Athkakaradi Rasayog 155, Page No.260. Cite this article: Clinical Trials Of Kamdudha Vati In Mukhapak Nilakshi Pradhan Ayurlog: National Journal of Research in Ayurved Science-2014; 3(1): 1-6 6