From www.bloodjournal.org by guest on October 15, 2014. For personal use only. 2014 124: e33-2469 124 (15) Updated information and services can be found at: http://www.bloodjournal.org/content/124/15.full.html Articles on similar topics can be found in the following Blood collections Information about reproducing this article in parts or in its entirety may be found online at: http://www.bloodjournal.org/site/misc/rights.xhtml#repub_requests Information about ordering reprints may be found online at: http://www.bloodjournal.org/site/misc/rights.xhtml#reprints Information about subscriptions and ASH membership may be found online at: http://www.bloodjournal.org/site/subscriptions/index.xhtml Blood (print ISSN 0006-4971, online ISSN 1528-0020), is published weekly by the American Society of Hematology, 2021 L St, NW, Suite 900, Washington DC 20036. Copyright 2011 by The American Society of Hematology; all rights reserved. From www.bloodjournal.org by guest on October 15, 2014. For personal use only. 9 OCTOBER 2014 x VOLUME 124, NUMBER 15 CONTENTS COVER FIGURE Immunoﬂuorescence microscopy of E12.5 yolk sac of a CD68-GFP transgenic mouse embryo. Monocytes and macrophages express the GFP reporter gene driven by the human CD68 promoter. Costaining with PECAM-1 shows close association between endothelial cells (red) and macrophages (green) in the developing vasculature. Nuclei are stained blue with the DNA dye DAPI. See the article by Iqbal et al on page e33. INSIDE BLOOD COMMENTARIES 2315 Renal risk and response in amyloidosis Angela Dispenzieri Comment on Palladini et al, page 2325 2316 It takes a village Naomi Winick Comment on Bhatia et al, page 2345 2317 Concealed dagger in FLT3/ITD1 AML Yishai Ofran Comment on Ostronoff et al, page 2400 2319 Inﬂammatory Langerhans cell differentiation Herbert Strobl Comment on Mart´ınez-Cingolani et al, page 2411 2320 Macrophages shine bright Oliver Soehnlein Comment on Iqbal et al, page e33 2322 Self-control of platelets: a new ITIM story Xiaoping Du Comment on Fan et al, page 2421 2323 CEA a thrombus CAM: CEACAM2, a twin of CEACAM1? Andrea Kristina Horst Comment on Alshahrani et al, page 2431 PLENARY PAPER 2325 A staging system for renal outcome and early markers of renal response to chemotherapy in AL amyloidosis Giovanni Palladini, Ute Hegenbart, Paolo Milani, Christoph Kimmich, Andrea Foli, Anthony D. Ho, Marta Vidus Rosin, Riccardo Albertini, Remigio Moratti, Giampaolo Merlini, and Stefan Sch¨onland BLOOD SPOTLIGHT 2333 Molecular and clinical predictors of inhibitor risk and its prevention and treatment in mild hemophilia A Giancarlo Castaman and Karin Fijnvandraat REVIEW ARTICLE 2337 Autoimmune and other cytopenias in primary immunodeﬁciencies: pathomechanisms, novel differential diagnoses, and treatment Markus G. Seidel ix BLOOD, 9 OCTOBER 2014 x VOLUME 124, NUMBER 15 CONTINUED ON x From www.bloodjournal.org by guest on October 15, 2014. For personal use only. CLINICAL TRIALS AND OBSERVATIONS 2345 6MP adherence in a multiracial cohort of children with acute lymphoblastic leukemia: a Children’s Oncology Group study Smita Bhatia, Wendy Landier, Lindsey Hageman, Heeyoung Kim, Yanjun Chen, Kristine R. Crews, William E. Evans, Bruce Bostrom, Jacqueline Casillas, David S. Dickens, Kelly W. Maloney, Joseph P. Neglia, Yaddanapudi Ravindranath, A. Kim Ritchey, F. Lennie Wong, and Mary V. Relling 2354 Impact of induction regimen and stem cell transplantation on outcomes in double-hit lymphoma: a multicenter retrospective analysis Adam M. Petrich, Mitul Gandhi, Borko Jovanovic, Jorge J. Castillo, Saurabh Rajguru, David T. Yang, Khushboo A. Shah, Jeremy D. Whyman, Frederick Lansigan, Francisco J. Hernandez-Ilizaliturri, Lisa X. Lee, Stefan K. Barta, Shruthi Melinamani, Reem Karmali, Camille Adeimy, Scott Smith, Neil Dalal, Chadi Nabhan, David Peace, Julie Vose, Andrew M. Evens, Namrata Shah, Timothy S. Fenske, Andrew D. Zelenetz, Daniel J. Landsburg, Christina Howlett, Anthony Mato, Michael Jaglal, Julio C. Chavez, Judy P. Tsai, Nishitha Reddy, Shaoying Li, Caitlin Handler, Christopher R. Flowers, Jonathon B. Cohen, Kristie A. Blum, Kevin Song, Haowei (Linda) Sun, Oliver Press, Ryan Cassaday, Jesse Jaso, L. Jeffrey Medeiros, Aliyah R. Sohani, and Jeremy S. Abramson HEMATOPOIESIS AND STEM CELLS 2362 UBAP2L is a novel BMI1-interacting protein essential for hematopoietic stem cell activity Marie-Eve Bordeleau, Romain Aucagne, Jalila Chagraoui, Simon Girard, Nadine Mayotte, ´ Bonneil, Pierre Thibault, Caroline Pabst, Anne Bergeron, Fr´ed´eric Barab´e, Jos´ee H´ebert, Eric Martin Sauvageau, Christel Boutonnet, Sylvain Meloche, and Guy Sauvageau IMMUNOBIOLOGY 2370 Loss of STAT3 in murine NK cells enhances NK cell–dependent tumor surveillance Dagmar Gotthardt, Eva M. Putz, Elisabeth Straka, Petra Kudweis, Mario Biaggio, Valeria Poli, Birgit Strobl, Mathias M¨uller, and Veronika Sexl LYMPHOID NEOPLASIA 2380 Cdk4 and Cdk6 cooperate in counteracting the INK4 family of inhibitors during murine leukemogenesis Esther Rodr´ıguez-D´ıez, Victor Quereda, Florian Bellutti, Michaela Prchal-Murphy, David Partida, Manuel Eguren, Karoline Kollmann, Marta G´omez de Cedr´on, Pierre Dubus, Marta Cañamero, Dolores Mart´ınez, Veronika Sexl, and Marcos Malumbres MYELOID NEOPLASIA 2391 The Runx-PU.1 pathway preserves normal and AML/ETO9a leukemic stem cells Philipp B. Staber, Pu Zhang, Min Ye, Robert S. Welner, Elena Levantini, Annalisa Di Ruscio, Alexander K. Ebralidze, Christian Bach, Hong Zhang, Junyan Zhang, Katrina Vanura, Ruud Delwel, Henry Yang, Gang Huang, and Daniel G. Tenen 2400 NUP98/NSD1 and FLT3/ITD coexpression is more prevalent in younger AML patients and leads to induction failure: a COG and SWOG report Fabiana Ostronoff, Megan Othus, Robert B. Gerbing, Michael R. Loken, Susana C. Raimondi, Betsy A. Hirsch, Beverly J. Lange, Stephen Petersdorf, Jerald Radich, Frederick R. Appelbaum, Alan S. Gamis, Todd A. Alonzo, and Soheil Meshinchi 2408 Brief Report Impact of early molecular response in children with chronic myeloid leukemia treated in the French Glivec phase 4 study Fr´ed´eric Millot, Joelle Guilhot, Andr´e Baruchel, Arnaud Petit, Yves Bertrand, Françoise Mazingue, Patrick Lutz, Cecile V´erit´e, Christian Berthou, Claire Galambrun, Nicolas Sirvent, Karima Yakouben, Claudine Schmitt, Virginie Gandemer, Yves Reguerre, G´erard Couillault, Françoise Mechinaud, and Jean-Michel Cayuela x BLOOD, 9 OCTOBER 2014 x VOLUME 124, NUMBER 15 CONTINUED ON xii From www.bloodjournal.org by guest on October 15, 2014. For personal use only. PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS 2411 Human blood BDCA-1 dendritic cells differentiate into Langerhans-like cells with thymic stromal lymphopoietin and TGF-b Carolina Mart´ınez-Cingolani, Maximilien Grandclaudon, Marine Jeanmougin, Mabel Jouve, Rapha¨el Zollinger, and Vassili Soumelis e33 e-Blood Human CD68 promoter GFP transgenic mice allow analysis of monocyte to macrophage differentiation in vivo Asif J. Iqbal, Eileen McNeill, Theodore S. Kapellos, Daniel Regan-Komito, Sophie Norman, Sarah Burd, Nicola Smart, Daniel E. W. Machemer, Elena Stylianou, Helen McShane, Keith M. Channon, Ajay Chawla, and David R. Greaves PLATELETS AND THROMBOPOIESIS 2421 Paired immunoglobulin-like receptor B regulates platelet activation Xuemei Fan, Panlai Shi, Jing Dai, Yeling Lu, Xue Chen, Xiaoye Liu, Kandi Zhang, Xiaolin Wu, Yueping Sun, Kemin Wang, Li Zhu, Cheng Cheng Zhang, Junfeng Zhang, Guo-qiang Chen, Junke Zheng, and Junling Liu 2431 CEACAM2 negatively regulates hemi (ITAM-bearing) GPVI and CLEC-2 pathways and thrombus growth in vitro and in vivo Musaed M. Alshahrani, Eunice Yang, Jana Yip, Simona S. Ghanem, Simon L. Abdallah, Anthony M. deAngelis, Cindy J. O’Malley, Fatemeh Moheimani, Sonia M. Najjar, and Denise E. Jackson THROMBOSIS AND HEMOSTASIS 2442 Binding of anti–platelet factor 4/heparin antibodies depends on the thermodynamics of conformational changes in platelet factor 4 Martin Kreimann, Sven Brandt, Krystin Krauel, Stephan Block, Christiane A. Helm, Werner Weitschies, Andreas Greinacher, and Mihaela Delcea 2450 The impact of bleeding complications in patients receiving target-speciﬁc oral anticoagulants: a systematic review and meta-analysis Chatree Chai-Adisaksopha, Mark Crowther, Tetsuya Isayama, and Wendy Lim TRANSPLANTATION 2459 Brief Report Impact of acute and chronic graft-versus-host disease on human B-cell generation and replication Salom´e Glauzy, Juliette Soret, Isabelle Fournier, Corinne Douay, H´el`ene Moins-Teisserenc, R´egis Peffault de Latour, Guitta Maki, Marie Robin, G´erard Soci´e, Antoine Toubert, and Emmanuel Clave BLOOD WORK 2463 Coexistent BCR-ABL1 and JAK2 V617F: converting CML dwarves to ET staghorns with imatinib therapy Craig Soderquist and Adam Bagg 2464 Basophilic blast phase of chronic myelogenous leukemia Hani M. Babiker and Maria Proytcheva CORRESPONDENCE 2465 The prognostic advantage of calreticulin mutations in myeloﬁbrosis might be conﬁned to type 1 or type 1-like CALR variants Ayalew Tefferi, Terra L. Lasho, Alexander Tischer, Emnet A. Wassie, Christy M. Finke, Alem A. Belachew, Rhett P. Ketterling, Curtis A. Hanson, and Animesh D. Pardanani xii BLOOD, 9 OCTOBER 2014 x VOLUME 124, NUMBER 15 CONTINUED ON xiii From www.bloodjournal.org by guest on October 15, 2014. For personal use only. 2467 Lenalidomide-induced diarrhea in patients with myeloma is caused by bile acid malabsorption that responds to treatment Charlotte Pawlyn, Mohid S. Khan, Ann Muls, Priya Sriskandarajah, Martin F. Kaiser, Faith E. Davies, Gareth J. Morgan, and H. Jervoise N. Andreyev ERRATA 2469 Lo SM, Choi M, Liu J, et al. Phenotype diversity in type 1 Gaucher disease: discovering the genetic basis of Gaucher disease/hematologic malignancy phenotype by individual genome analysis. Blood. 2012;119(20):4731-4740. OTHER DEPARTMENTS xxiii iiib Author Guide Classiﬁeds SUBMISSION INSTRUCTIONS All manuscripts, including ﬁgures, should be submitted electronically at http://submit.bloodjournal.org to Editor-in-Chief Bob L¨owenberg, MD, PhD. Before submitting your paper, review Blood’s Author Guide at http://bloodjournal.hematologylibrary.org/site/authors/ authorguide.xhtml. If you need help during the submission process, contact the Editorial Ofﬁce by phone at 202-776-0548 or via e-mail at editorial@hematology.org. xiii BLOOD, 9 OCTOBER 2014 x VOLUME 124, NUMBER 15