From www.bloodjournal.org by guest on December 3, 2014. For personal use only. 2014 124: 3177-3335 124 (22) Updated information and services can be found at: http://www.bloodjournal.org/content/124/22.full.html Articles on similar topics can be found in the following Blood collections Information about reproducing this article in parts or in its entirety may be found online at: http://www.bloodjournal.org/site/misc/rights.xhtml#repub_requests Information about ordering reprints may be found online at: http://www.bloodjournal.org/site/misc/rights.xhtml#reprints Information about subscriptions and ASH membership may be found online at: http://www.bloodjournal.org/site/subscriptions/index.xhtml Blood (print ISSN 0006-4971, online ISSN 1528-0020), is published weekly by the American Society of Hematology, 2021 L St, NW, Suite 900, Washington DC 20036. Copyright 2011 by The American Society of Hematology; all rights reserved. From www.bloodjournal.org by guest on December 3, 2014. For personal use only. 20 NOVEMBER 2014 x VOLUME 124, NUMBER 22 CONTENTS COVER FIGURE Image of red ﬂuorescent protein–expressing human umbilical vein endothelial cells (RFP1 HUVECs) (red) in coculture with green ﬂuorescent protein–expressing (GFP1) MM1S myeloma cells (green) at day 9 of culture in endothelial growth medium on 3-dimensional porous silk scaffolds (purple). GFP1 MM1S cell adherence to RFP1 HUVECs and incorporation into the capillarylike endothelial cell structures can be observed and may model the early stages of angiogenesis. GFP1 MM1S cells are seen clustered and colocalized at endothelial protrusions. The image is the maximum projection of z-stacked confocal images at 320 magniﬁcation on a Leica SP5X laser scanning confocal microscope. See the article by Reagan et al on page 3250. INSIDE BLOOD COMMENTARIES 3177 Polyphosphate: a target for thrombosis attenuation Roberto Docampo Comment on Travers et al, page 3183 3178 The end of knight-errantry in GVHD studies Marcos de Lima Comment on Bolaños-Meade et al, page 3221 3179 Not merely quiescent: telomeres in quiescent HSCs Ayako Nakamura-Ishizu and Toshio Suda Comment on Wang et al, page 3237 3180 Fc-optimized antibodies quickly pull the trigger Christian Kellner and Matthias Peipp Comment on Romain et al, page 3241 PLENARY PAPER 3183 Nontoxic polyphosphate inhibitors reduce thrombosis while sparing hemostasis Richard J. Travers, Rajesh A. Shenoi, Manu Thomas Kalathottukaren, Jayachandran N. Kizhakkedathu, and James H. Morrissey PERSPECTIVES 3191 Biosimilars: the science of extrapolation Martina Weise, Pekka Kurki, Elena Wolff-Holz, Marie-Christine Bielsky, and Christian K. Schneider BLOOD SPOTLIGHT 3197 Brentuximab vedotin Stephen M. Ansell REVIEW ARTICLE 3201 The role of the thymus in T-cell immune reconstitution after umbilical cord blood transplantation Ioannis Politikos and Vassiliki A. Boussiotis HOW I TREAT 3212 How I treat polycythemia vera Alessandro M. Vannucchi vii BLOOD, 20 NOVEMBER 2014 x VOLUME 124, NUMBER 22 CONTINUED ON viii From www.bloodjournal.org by guest on December 3, 2014. For personal use only. CLINICAL TRIALS AND OBSERVATIONS 3221 CME Article Phase 3 clinical trial of steroids/mycophenolate mofetil vs steroids/placebo as therapy for acute GVHD: BMT CTN 0802 Javier Bolaños-Meade, Brent R. Logan, Amin M. Alousi, Joseph H. Antin, Kate Barowski, Shelly L. Carter, Steven C. Goldstein, Elizabeth O. Hexner, Mary M. Horowitz, Stephanie J. Lee, John E. Levine, Margaret L. MacMillan, Paul J. Martin, Adam M. Mendizabal, Ryotaro Nakamura, Marcelo C. Pasquini, Daniel J. Weisdorf, Peter Westervelt, and Vincent T. Ho 3228 Safety and efﬁcacy of rituximab in adult immune thrombocytopenia: results from a prospective registry including 248 patients Mehdi Khellaf, Ana¨ıs Charles-Nelson, Olivier Fain, Louis Terriou, Jean-François Viallard, St´ephane Cheze, Julie Graveleau, Borhane Slama, Sylvain Audia, Mikael Ebbo, Guillaume Le Guenno, Manuel Cliquennois, Gilles Salles, Caroline Bonmati, France Teillet, Lionel Galicier, Arnaud Hot, Olivier Lambotte, François Lefr`ere, Salimatou Sacko, Dieudonn´e Kilendo Kengue, Philippe Bierling, Françoise Roudot-Thoraval, Marc Michel, and Bertrand Godeau HEMATOPOIESIS AND STEM CELLS 3237 Brief Report Senescence and apoptosis block hematopoietic activation of quiescent hematopoietic stem cells with short telomeres Jianwei Wang, Xin Lu, Vadim Sakk, Christoph A. Klein, and Karl Lenhard Rudolph IMMUNOBIOLOGY 3241 Antibody Fc engineering improves frequency and promotes kinetic boosting of serial killing mediated by NK cells Gabrielle Romain, Vladimir Senyukov, Nicolas Rey-Villamizar, Amine Merouane, William Kelton, Ivan Liadi, Ankit Mahendra, Wissam Charab, George Georgiou, Badrinath Roysam, Dean A. Lee, and Navin Varadarajan LYMPHOID NEOPLASIA 3250 Investigating osteogenic differentiation in multiple myeloma using a novel 3D bone marrow niche model Michaela R. Reagan, Yuji Mishima, Siobhan V. Glavey, Yong Zhang, Salomon Manier, Zhi Ning Lu, Masoumeh Memarzadeh, Yu Zhang, Antonio Sacco, Yosra Aljawai, Jiantao Shi, Yu-Tzu Tai, John E. Ready, David L. Kaplan, Aldo M. Roccaro, and Irene M. Ghobrial MYELOID NEOPLASIA 3260 BCR-ABL1 promotes leukemia by converting p27 into a cytoplasmic oncoprotein Anupriya Agarwal, Ryan J. Mackenzie, Arnaud Besson, Sophia Jeng, Alyssa Carey, Dorian H. LaTocha, Angela G. Fleischman, Nicolas Duquesnes, Christopher A. Eide, Kavin B. Vasudevan, Marc M. Loriaux, Eduardo Firpo, Jorge E. Cortes, Shannon McWeeney, Thomas O’Hare, James M. Roberts, Brian J. Druker, and Michael W. Deininger 3274 NRASG12V oncogene facilitates self-renewal in a murine model of acute myelogenous leukemia Zohar Sachs, Rebecca S. LaRue, Hanh T. Nguyen, Karen Sachs, Klara E. Noble, Nurul Azyan Mohd Hassan, Ernesto Diaz-Flores, Susan K. Rathe, Aaron L. Sarver, Sean C. Bendall, Ngoc A. Ha, Miechaleen D. Diers, Garry P. Nolan, Kevin M. Shannon, and David A. Largaespada 3284 GPR84 sustains aberrant b-catenin signaling in leukemic stem cells for maintenance of MLL leukemogenesis Philipp A. Dietrich, Chen Yang, Halina H. L. Leung, Jennifer R. Lynch, Estrella Gonzales, Bing Liu, Michelle Haber, Murray D. Norris, Jianlong Wang, and Jenny Yingzi Wang PLATELETS AND THROMBOPOIESIS 3295 Clinical and laboratory predictors of chronic immune thrombocytopenia in children: a systematic review and meta-analysis Katja M. J. Heitink-Poll´e, Joyce Nijsten, Chantal W. B. Boonacker, Masja de Haas, and Marrie C. A. Bruin viii BLOOD, 20 NOVEMBER 2014 x VOLUME 124, NUMBER 22 CONTINUED ON x From www.bloodjournal.org by guest on December 3, 2014. For personal use only. 3308 Epidemiology of incident immune thrombocytopenia: a nationwide population-based study in France Guillaume Moulis, Aurore Palmaro, Jean-Louis Montastruc, Bertrand Godeau, Maryse Lapeyre-Mestre, and Laurent Sailler THROMBOSIS AND HEMOSTASIS 3316 Brief Report Interleukin 27 inhibits cytotoxic T-lymphocyte-mediated platelet destruction in primary immune thrombocytopenia Hai Zhou, Ji-hua Qiu, Tong Wang, Ying-yi Yu, Xue-na Liu, Xin Li, Ya-wen Wang, Yu Hou, Li-zhen Li, Xin-guang Liu, Ming Hou, and Jun Peng TRANSPLANTATION 3320 CD41 invariant natural killer T cells protect from murine GVHD lethality through expansion of donor CD41CD251FoxP31 regulatory T cells Dominik Schneidawind, Antonio Pierini, Maite Alvarez, Yuqiong Pan, Jeanette Baker, Corina Buechele, Richard H. Luong, Everett H. Meyer, and Robert S. Negrin BLOOD WORK 3329 EBV-positive peripheral T-cell lymphoma with extensive hemophagocytosis Mithun Vinod Shah and Ronald S. Go CORRESPONDENCE 3330 KIR3DL2 is a coinhibitory receptor on S´ezary syndrome malignant T cells that promotes resistance to activation-induced cell death Nicolas Thonnart, Anne Caudron, Isabel Legaz, Martine Bagot, Armand Bensussan, and Anne Marie-Cardine 3332 Nongenetic stochastic expansion of JAK2V617F-homozygous subclones in polycythemia vera? Anna L. Godfrey, Jyoti Nangalia, E. Joanna Baxter, Charles E. Massie, David G. Kent, Elli Papaemmanuil, Peter J. Campbell, and Anthony R. Green CONTINUING MEDICAL EDUCATION (CME) QUESTIONS 3335 Phase 3 study of mycophenolate mofetil in GVHD OTHER DEPARTMENTS ivb Classiﬁeds SUBMISSION INSTRUCTIONS All manuscripts, including ﬁgures, should be submitted electronically at http://submit.bloodjournal.org to Editor-in-Chief Bob L¨owenberg, MD, PhD. Before submitting your paper, review Blood’s Author Guide at http://bloodjournal.hematologylibrary.org/site/authors/ authorguide.xhtml. If you need help during the submission process, contact the Editorial Ofﬁce by phone at 202-776-0548 or via e-mail at editorial@hematology.org. x BLOOD, 20 NOVEMBER 2014 x VOLUME 124, NUMBER 22