From www.bloodjournal.org by guest on October 21, 2014. For personal use only. 2014 124: 2471-2615 124 (16) Updated information and services can be found at: http://www.bloodjournal.org/content/124/16.full.html Articles on similar topics can be found in the following Blood collections Information about reproducing this article in parts or in its entirety may be found online at: http://www.bloodjournal.org/site/misc/rights.xhtml#repub_requests Information about ordering reprints may be found online at: http://www.bloodjournal.org/site/misc/rights.xhtml#reprints Information about subscriptions and ASH membership may be found online at: http://www.bloodjournal.org/site/subscriptions/index.xhtml Blood (print ISSN 0006-4971, online ISSN 1528-0020), is published weekly by the American Society of Hematology, 2021 L St, NW, Suite 900, Washington DC 20036. Copyright 2011 by The American Society of Hematology; all rights reserved. From www.bloodjournal.org by guest on October 21, 2014. For personal use only. 16 OCTOBER 2014 x VOLUME 124, NUMBER 16 CONTENTS COVER FIGURE Immunoconfocal analysis of proplatelet forming megakaryocyte derived in vitro from a single CD34 cell of a patient with homozygous PRKACG mutation. Megakaryocyte was allowed to adhere on ﬁbrinogen for 2 hours at day 13 of culture, and stained with antitubulin (red), anti-WF (green) and DAPI (blue). See the article by Manchev et al on page 2554. INSIDE BLOOD COMMENTARIES 2471 Life, genes, and death in Ph2 MPNs Richard T. Silver Comment on Tefferi et al, page 2507 2472 The hemangioblast revisited Marella de Bruijn Comment on Padr´on-Barthe et al, page 2523 2473 Inherited macrothrombocytopenias on the rise Carolina Landolt-Marticorena and Walter H. A. Kahr Comment on Manchev et al, page 2554 2475 PMNs deliver ﬁrst aid to clot Donna S. Woulfe Comment on Darbousset et al, page 2575 2476 HLA-DP1 matching: are we there yet? Arnon Nagler Comment on Pidala et al, page 2596 REVIEW ARTICLE 2479 Impact of interferon-g on hematopoiesis Alexander M. de Bruin, Carlijn Voermans, and Martijn A. Nolte 2487 Bedside to bench in juvenile myelomonocytic leukemia: insights into leukemogenesis from a rare pediatric leukemia Tiffany Y. Chang, Christopher C. Dvorak, and Mignon L. Loh CLINICAL TRIALS AND OBSERVATIONS 2498 Long-term follow-up from a phase 1/2 study of single-agent bortezomib in relapsed systemic AL amyloidosis Donna E. Reece, Ute Hegenbart, Vaishali Sanchorawala, Giampaolo Merlini, Giovanni Palladini, Joan Blad´e, Jean-Paul Fermand, Hani Hassoun, Leonard Heffner, Vishal Kukreti, Robert A. Vescio, Lixia Pei, Christopher Enny, Dixie-Lee Esseltine, Helgi van de Velde, Andrew Cakana, and Raymond L. Comenzo 2507 CME Article Long-term survival and blast transformation in molecularly annotated essential thrombocythemia, polycythemia vera, and myeloﬁbrosis Ayalew Tefferi, Paola Guglielmelli, Dirk R. Larson, Christy Finke, Emnet A. Wassie, Lisa Pieri, Naseema Gangat, Rajmonda Fjerza, Alem A. Belachew, Terra L. Lasho, Rhett P. Ketterling, Curtis A. Hanson, Alessandro Rambaldi, Guido Finazzi, Juergen Thiele, Tiziano Barbui, Animesh Pardanani, and Alessandro M. Vannucchi vii BLOOD, 16 OCTOBER 2014 x VOLUME 124, NUMBER 16 CONTINUED ON viii From www.bloodjournal.org by guest on October 21, 2014. For personal use only. GENE THERAPY 2514 Towards gene therapy for EBV-associated posttransplant lymphoma with genetically modiﬁed EBV-speciﬁc cytotoxic T cells Ida Ricciardelli, Michael Patrick Blundell, Jennifer Brewin, Adrian Thrasher, Martin Pule, and Persis J. Amrolia HEMATOPOIESIS AND STEM CELLS 2523 Clonal analysis identiﬁes hemogenic endothelium as the source of the blood-endothelial common lineage in the mouse embryo Laura Padr´on-Barthe, Susana Temiño, Cristina Villa del Campo, Laura Carramolino, Joan Isern, and Miguel Torres IMMUNOBIOLOGY 2533 Role for early-differentiated natural killer cells in infectious mononucleosis Tarik Azzi, Anna L¨unemann, Anita Murer, Seigo Ueda, Vivien B´eziat, Karl-Johan Malmberg, Georg Staubli, Claudine Gysin, Christoph Berger, Christian M¨unz, Obinna Chijioke, and David Nadal LYMPHOID NEOPLASIA 2544 Exome sequencing reveals novel mutation targets in diffuse large B-cell lymphomas derived from Chinese patients Noel F. C. C. de Miranda, Konstantinos Georgiou, Longyun Chen, Chenglin Wu, Zhibo Gao, Apostolos Zaravinos, Susana Lisboa, Gunilla Enblad, Manuel R. Teixeira, Yixin Zeng, Roujun Peng, and Qiang Pan-Hammarstr¨om PLATELETS AND THROMBOPOIESIS 2554 A new form of macrothrombocytopenia induced by a germ-line mutation in the PRKACG gene Vladimir T. Manchev, Morgane Hilpert, Eliane Berrou, Ziane Elaib, Achille Aouba, Siham Boukour, Sylvie Souquere, Gerard Pierron, Philippe Rameau, Robert Andrews, François Lanza, Regis Bobe, William Vainchenker, Jean-Philippe Rosa, Marijke Bryckaert, Najet Debili, Remi Favier, and Hana Raslova 2564 Brief Report Carboxyl-terminal-dependent recruitment of nonmuscle myosin II to megakaryocyte contractile ring during polyploidization Idinath Badirou, Jiajia Pan, C´eline Legrand, Aibing Wang, Larissa Lordier, Siham Boukour, Anita Roy, William Vainchenker, and Yunhua Chang RED CELLS, IRON, AND ERYTHROPOIESIS 2569 Erythroferrone contributes to recovery from anemia of inﬂammation L´eon Kautz, Grace Jung, Elizabeta Nemeth, and Tomas Ganz THROMBOSIS AND HEMOSTASIS 2575 P2X1 expressed on polymorphonuclear neutrophils and platelets is required for thrombosis in mice Roxane Darbousset, C´eline Delierneux, Soraya Mezouar, Alexandre Hego, Christelle Lecut, Isabelle Guillaumat, Markus A. Riederer, Richard J. Evans, Françoise Dignat-George, Laurence Panicot-Dubois, C´ecile Oury, and Christophe Dubois TRANSPLANTATION 2586 MiR-146a regulates the TRAF6/TNF-axis in donor T cells during GVHD Natalie Stickel, Gabriele Prinz, Dietmar Pfeifer, Peter Hasselblatt, Annette Schmitt-Graeff, Marie Follo, Robert Thimme, J¨urgen Finke, Justus Duyster, Ulrich Salzer, and Robert Zeiser viii BLOOD, 16 OCTOBER 2014 x VOLUME 124, NUMBER 16 CONTINUED ON ix From www.bloodjournal.org by guest on October 21, 2014. For personal use only. 2596 Nonpermissive HLA-DPB1 mismatch increases mortality after myeloablative unrelated allogeneic hematopoietic cell transplantation Joseph Pidala, Stephanie J. Lee, Kwang Woo Ahn, Stephen Spellman, Hai-Lin Wang, Mahmoud Aljurf, Medhat Askar, Jason Dehn, Marcelo Fernandez Viña, Alois Gratwohl, Vikas Gupta, Rabi Hanna, Mary M. Horowitz, Carolyn K. Hurley, Yoshihiro Inamoto, Adetola A. Kassim, Taiga Nishihori, Carlheinz Mueller, Machteld Oudshoorn, Efﬁe W. Petersdorf, Vinod Prasad, James Robinson, Wael Saber, Kirk R. Schultz, Bronwen Shaw, Jan Storek, William A. Wood, Ann E. Woolfrey, and Claudio Anasetti BLOOD WORK 2607 Lymphoproliferative disorder with Auer rod–like inclusions Matthew J. Oberley and David T. Yang 2608 Sequential development of different acute leukemia types in the same patient Ioannis Kotsianidis and Constantinos Tsatalas 2609 Childhood myelodysplastic syndrome associated with an acquired Bernard-Soulier–like platelet dysfunction Marco Frigeni and Monica Galli CORRESPONDENCE 2610 The BRAF-V600E mutation in circulating cell-free DNA is a promising biomarker of high-risk adult Langerhans cell histiocytosis Masayuki Kobayashi and Arinobu Tojo 2611 Calreticulin mutation does not modify the IPSET score for predicting the risk of thrombosis among 1150 patients with essential thrombocythemia Guido Finazzi, Alessandra Carobbio, Paola Guglielmelli, Chiara Cavalloni, Silvia Salmoiraghi, Alessandro M. Vannucchi, Mario Cazzola, Francesco Passamonti, Alessandro Rambaldi, and Tiziano Barbui 2613 New nucleotide polymerase inhibitors to rapidly permit hematopoietic stem cell donation from a positive HCV-RNA donor Florence Beckerich, Christophe H´ezode, Christine Robin, Jean-Louis Beaumont, Eric Gautier, S´ebastien Maury, and Catherine Cordonnier CONTINUING MEDICAL EDUCATION (CME) QUESTIONS 2615 Mutation-speciﬁc survival in MPN OTHER DEPARTMENTS xxvii iib Author Guide Classiﬁeds SUBMISSION INSTRUCTIONS All manuscripts, including ﬁgures, should be submitted electronically at http://submit.bloodjournal.org to Editor-in-Chief Bob L¨owenberg, MD, PhD. Before submitting your paper, review Blood’s Author Guide at http://bloodjournal.hematologylibrary.org/site/authors/ authorguide.xhtml. If you need help during the submission process, contact the Editorial Ofﬁce by phone at 202-776-0548 or via e-mail at editorial@hematology.org. ix BLOOD, 16 OCTOBER 2014 x VOLUME 124, NUMBER 16